Pierre Jean Valette

Exploration de l'intestin grêle par les techniques d'imagerie en coupes

Resume Les progres recents de l’imagerie en coupes permettent d’explorer de facon satisfaisante l’intestin grele. Ce chapitre abordera la technique et les principales indications.

Resectability of Peritoneal Carcinomatosis: Learnings from a Prospective Cohort of 533 Consecutive Patients Selected for Cytoreductive Surgery

AbstractPurposeThe aim of this study was to identify the risk factors and causes of unresectability in a large cohort of patients with peritoneal carcinomatosis (PC) selected for cytoreductive surgery (CRS), and to assess the contribution of the different imaging modalities to the patient-selection process.MethodsThe pre- and intraoperative data of 533 consecutive patients with PC planned for CRS at a single institution were reviewed. All patients underwent computed tomography (CT) magnetic resonance imaging and/or positron emission tomography/CT within the 2xa0days prior to surgery.ResultsAmong the 533 patients, 436 (82xa0%) underwent complete CRS, 86 (16xa0%) underwent exploratory laparotomy without CRS because of multiple small-bowel involvement (nxa0=xa031), invasion of different digestive segments (nxa0=xa015), an elevated PC index (nxa0=xa014), invasion of the mesenteric root (nxa0=xa012), or another cause (nxa0=xa014), and 11 (2xa0%) did not undergo laparotomy because of disease progression on preoperative imaging findings. On univariate analysis, elevated levels of tumor markers and a short delay between the last cycle of chemotherapy and the scheduled surgery were identified as predictors of unresectability for the colonic PC population, while a younger age was identified in patients with gastric PC. Multivariate analysis disclosed the use of neoadjuvant chemotherapy and a younger age as independent predictors of unresectability in the colonic PC population.nConclusionsThe current modalities for the assessment of PC resectability, including functional imaging examinations, have a low impact on patient selection for CRS. New tools are needed to decrease the rate of open–close procedures.