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Featured researches published by Piers Ettinger-Epstein.


Marine Biotechnology | 2008

Quorum sensing antagonism from marine organisms

Mette E. Skindersoe; Piers Ettinger-Epstein; Thomas Bovbjerg Rasmussen; Thomas Bjarnsholt; Rocky de Nys; Michael Givskov

With the global emergence of multiresistant bacteria there is an increasing demand for development of new treatments to combat pathogens. Bacterial cell–cell communication [quorum sensing (QS)] regulates expression of virulence factors in a number of bacterial pathogens and is a new promising target for the control of infectious bacteria. We present the results of screening of 284 extracts of marine organisms from the Great Barrier Reef, Australia, for their inhibition of QS. Of the 284 extracts, 64 (23%) were active in a general, LuxR-derived QS screen, and of these 36 (56%) were also active in a specific Pseudomonas aeruginosa QS screen. Extracts of the marine sponge Luffariella variabilis proved active in both systems. The secondary metabolites manoalide, manoalide monoacetate, and secomanoalide isolated from the sponge showed strong QS inhibition of a lasB::gfp(ASV) fusion, demonstrating the potential for further identification of specific QS antagonists from marine organisms.


Coral Reefs | 2008

The effect of temperature on larval pre-settlement duration and metamorphosis for the sponge, Rhopaloeides odorabile

S. Whalan; Piers Ettinger-Epstein; R. de Nys

Rising sea temperatures may potentially affect the dispersive larval phase of sessile marine invertebrates with consequences for the viability of adult populations. This study demonstrated that the planktonic larvae of Rhopaloeides odorabile, a common Great Barrier Reef sponge, survived and metamorphosed when exposed to temperatures up to 9°C above the annual maximum (~29°C). Planktonic larval duration of 54 h, at ambient temperatures (~28°C), were reduced to 18 h for larvae exposed to elevated temperatures (32–36°C). Moreover, at ambient temperatures larvae began metamorphosing after 12 h, but at 32–36°C this reduced to only 2 h. Larvae survived and could still metamorphose at temperatures as high as 38°C, but were no longer functional at 40°C. These results imply that predicted increases in sea surface temperature may reduce planktonic larval duration and dispersal capabilities, thereby contributing to population subdivision of the species.


Marine Drugs | 2010

ESI FTICR-MS Analysis of Larvae from the Marine Sponge Luffariella variabilis

Cherie A. Motti; Piers Ettinger-Epstein; Richard H. Willis; Dianne M. Tapiolas

The viviparous Great Barrier Reef sponge Luffariella variabilis (Poléjaeff 1884) contains a range of secondary metabolites, including manoalide (1) and manoalide monoacetate (3). ESI (+) FTICR-MS accurate mass determination has, for the first time, been used to detected the presence of 3 only in an organic extract of a single L. variabilis larva showing that the parentally produced 3 is sequestered in the larva. As 3 has previously been shown to have antibacterial and quorum sensing inhibition activity, and readily converts to 1, which also exhibits similar activity, it may provide a chemical defence against predation and microbial attack.


Environmental Microbiology | 2008

Diversity and mode of transmission of ammonia‐oxidizing archaea in marine sponges

Doris Steger; Piers Ettinger-Epstein; S. Whalan; Ute Hentschel; Rocky de Nys; Michael Wagner; Michael W. Taylor


Marine Ecology Progress Series | 2008

Larval vertical migration and hierarchical selectivity of settlement in a brooding marine sponge

S. Whalan; Piers Ettinger-Epstein; Christopher N. Battershill; R. de Nys


Marine Ecology Progress Series | 2008

A hierarchy of settlement cues influences larval behaviour in a coral reef sponge

Piers Ettinger-Epstein; Steve W Whalan; Christopher N. Battershill; Rocky de Nys


Marine Biology | 2007

Temperature cues gametogenesis and larval release in a tropical sponge

Piers Ettinger-Epstein; Steve W Whalan; Christopher N. Battershill; Rocky de Nys


Journal of Natural Products | 2007

Acetylated Sesterterpenes from the Great Barrier Reef Sponge Luffariella variabilis

Piers Ettinger-Epstein; Cherie A. Motti; Rocky de Nys; Anthony D. Wright; Christopher N. Battershill; Dianne M. Tapiolas


Marine Biotechnology | 2008

Production of Manoalide and Its Analogues by the Sponge Luffariella variabilis Is Hardwired

Piers Ettinger-Epstein; Dianne M. Tapiolas; Cherie A. Motti; Anthony D. Wright; Christopher N. Battershill; Rocky de Nys


Austral Ecology | 2008

Effects of the El Niño southern oscillation on Turbo torquatus (Gastropoda) and their kelp habitat

Piers Ettinger-Epstein; Michael J. Kingsford

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Christopher N. Battershill

Australian Institute of Marine Science

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Cherie A. Motti

Australian Institute of Marine Science

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Dianne M. Tapiolas

Australian Institute of Marine Science

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S. Whalan

James Cook University

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R. de Nys

James Cook University

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Steve W Whalan

Southern Cross University

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Anthony D. Wright

University of Hawaii at Hilo

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Richard H. Willis

Australian Institute of Marine Science

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