Piers Ettinger-Epstein
James Cook University
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Publication
Featured researches published by Piers Ettinger-Epstein.
Marine Biotechnology | 2008
Mette E. Skindersoe; Piers Ettinger-Epstein; Thomas Bovbjerg Rasmussen; Thomas Bjarnsholt; Rocky de Nys; Michael Givskov
With the global emergence of multiresistant bacteria there is an increasing demand for development of new treatments to combat pathogens. Bacterial cell–cell communication [quorum sensing (QS)] regulates expression of virulence factors in a number of bacterial pathogens and is a new promising target for the control of infectious bacteria. We present the results of screening of 284 extracts of marine organisms from the Great Barrier Reef, Australia, for their inhibition of QS. Of the 284 extracts, 64 (23%) were active in a general, LuxR-derived QS screen, and of these 36 (56%) were also active in a specific Pseudomonas aeruginosa QS screen. Extracts of the marine sponge Luffariella variabilis proved active in both systems. The secondary metabolites manoalide, manoalide monoacetate, and secomanoalide isolated from the sponge showed strong QS inhibition of a lasB::gfp(ASV) fusion, demonstrating the potential for further identification of specific QS antagonists from marine organisms.
Coral Reefs | 2008
S. Whalan; Piers Ettinger-Epstein; R. de Nys
Rising sea temperatures may potentially affect the dispersive larval phase of sessile marine invertebrates with consequences for the viability of adult populations. This study demonstrated that the planktonic larvae of Rhopaloeides odorabile, a common Great Barrier Reef sponge, survived and metamorphosed when exposed to temperatures up to 9°C above the annual maximum (~29°C). Planktonic larval duration of 54 h, at ambient temperatures (~28°C), were reduced to 18 h for larvae exposed to elevated temperatures (32–36°C). Moreover, at ambient temperatures larvae began metamorphosing after 12 h, but at 32–36°C this reduced to only 2 h. Larvae survived and could still metamorphose at temperatures as high as 38°C, but were no longer functional at 40°C. These results imply that predicted increases in sea surface temperature may reduce planktonic larval duration and dispersal capabilities, thereby contributing to population subdivision of the species.
Marine Drugs | 2010
Cherie A. Motti; Piers Ettinger-Epstein; Richard H. Willis; Dianne M. Tapiolas
The viviparous Great Barrier Reef sponge Luffariella variabilis (Poléjaeff 1884) contains a range of secondary metabolites, including manoalide (1) and manoalide monoacetate (3). ESI (+) FTICR-MS accurate mass determination has, for the first time, been used to detected the presence of 3 only in an organic extract of a single L. variabilis larva showing that the parentally produced 3 is sequestered in the larva. As 3 has previously been shown to have antibacterial and quorum sensing inhibition activity, and readily converts to 1, which also exhibits similar activity, it may provide a chemical defence against predation and microbial attack.
Environmental Microbiology | 2008
Doris Steger; Piers Ettinger-Epstein; S. Whalan; Ute Hentschel; Rocky de Nys; Michael Wagner; Michael W. Taylor
Marine Ecology Progress Series | 2008
S. Whalan; Piers Ettinger-Epstein; Christopher N. Battershill; R. de Nys
Marine Ecology Progress Series | 2008
Piers Ettinger-Epstein; Steve W Whalan; Christopher N. Battershill; Rocky de Nys
Marine Biology | 2007
Piers Ettinger-Epstein; Steve W Whalan; Christopher N. Battershill; Rocky de Nys
Journal of Natural Products | 2007
Piers Ettinger-Epstein; Cherie A. Motti; Rocky de Nys; Anthony D. Wright; Christopher N. Battershill; Dianne M. Tapiolas
Marine Biotechnology | 2008
Piers Ettinger-Epstein; Dianne M. Tapiolas; Cherie A. Motti; Anthony D. Wright; Christopher N. Battershill; Rocky de Nys
Austral Ecology | 2008
Piers Ettinger-Epstein; Michael J. Kingsford