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Pingli Liu

Incyte

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Featured researches published by Pingli Liu.

Organic Letters | 2009

Enantioselective Synthesis of Janus Kinase Inhibitor INCB018424 via an Organocatalytic Aza-Michael Reaction

Qiyan Lin; David Meloni; Yongchun Pan; Michael Xia; James D. Rodgers; Stacey Shepard; Mei Li; Laurine Galya; Brian Walter Metcalf; Tai-Yuen Yue; Pingli Liu; Jiacheng Zhou

An enantioselective synthesis of INCB018424 via organocatalytic asymmetric aza-Michael addition of pyrazoles (16 or 20) to (E)-3-cyclopentylacrylaldehyde (23) using diarylprolinol silyl ether as the catalyst was developed. Michael adducts (R)-24 and (R)-27 were isolated in good yield and high ee and were readily converted to INCB018424.

Archive | 2009

Azetidine and cyclobutane derivatives as jak inhibitors

James D. Rodgers; Stacey Shepard; Yun-Long Li; Jiacheng Zhou; Pingli Liu; David Meloni; Michael Xia

Archive | 2010

Processes for preparing JAK inhibitors and related intermediate compounds

Jiacheng Zhou; Pingli Liu; Qiyan Lin; Brian Metcalf; David Meloni; Yongchun Pan; Michael Xia; Mei Li; Tai-Yuen Yue; James D. Rodgers; Haisheng Wang

Archive | 2015

Processes of preparing a jak1 inhibitor and new forms thereto

Jiacheng Zhou; Pingli Liu; Shili Chen; Yongzhong Wu; Dengjin Wang; Zhongjiang Jia; Lei Qiao; William Frietze; Michael Xia; Yingrui Dai

Archive | 2016

SALTS AND PROCESSES OF PREPARING A PI3K INHIBITOR

Lei Qiao; Lingkai Weng; Chongshen Eric Shi; David Meloni; Qiyan Lin; Michael Xia; Vaqar Sharief; William Frietze; Zhongjiang Jia; Yongchun Pan; Pingli Liu; Tai-Yuen Yue; Jiacheng Zhou

Archive | 2018

FORMA SÓLIDA AMORFA DE UN INHIBIDOR DE PROTEÍNA BET

Jiacheng Zhou; Pingli Liu; Zhongjiang Jia; William Frietze; Shili Chen

Archive | 2017

AMORPHOUS SOLID FORM OF A BET PROTEIN INHIBITOR

Shili Chen; William Frietze; Zhongjiang Jia; Pingli Liu; Jiacheng Zhou

Archive | 2016

Salts of pi3k inhibitor and processes for their preparation

Lei Qiao; Lingkai Weng; Chongsheng Eric Shi; David Meloni; Qiyan Lin; Michael Xia; Vaqar Sharief; William Frietze; Zhongjiang Jia; Yongchun Pan; Pingli Liu; Tai-Yuen Yue; Jiacheng Zhou

Archive | 2015

Procédés de préparation d'un inhibiteur de jak1 et nouvelles formes associées

Jiacheng Zhou; Pingli Liu; Shili Chen; Yongzhong Wu; Dengjin Wang; Zhongjiang Jia; Lei Qiao; William Frietze; Michael Xia; Yingrui Dai

Archive | 2010

Procédés de préparation d'inhibiteurs des jak et composés intermédiaires apparentés

Jiacheng Zhou; Pingli Liu; Qiyan Lin; Brian Walter Metcalf; David Meloni; Yongchun Pan; Michael Xia; Mei Li; Tai-Yuen Yue; James D. Rodgers; Haisheng Wang

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Jiacheng Zhou

Incyte

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Michael Xia

Incyte

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David Meloni

Incyte

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Qiyan Lin

Incyte

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Tai-Yuen Yue

Incyte

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Yongchun Pan

Incyte

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James D. Rodgers

Janssen Pharmaceutica

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Stacey Shepard

Incyte

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William Frietze

Incyte

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Zhongjiang Jia

Incyte

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