Pingrong Liu
Boehringer Ingelheim
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Publication
Featured researches published by Pingrong Liu.
Bioorganic & Medicinal Chemistry Letters | 2016
Joshua Courtney Horan; Daniel Kuzmich; Pingrong Liu; Darren Disalvo; John Lord; Can Mao; Tamara Denise Hopkins; Hui Yu; Christian Harcken; Raj Betageri; Melissa Hill-Drzewi; Lori Patenaude; Monica Patel; Kimberly Fletcher; Donna Terenzzio; Brian Linehan; Heather Xia; Mita Patel; Debbie Studwell; Craig Andrew Miller; Eugene R. Hickey; Jeremy I. Levin; Dustin Smith; Raymond A. Kemper; Louise K. Modis; Lynne Canne Bannen; Diva Sze-Ming Chan; Morrison B. Mac; Stephanie Ng; Yong Wang
Poor solubility and cationic amphiphilic drug-likeness were liabilities identified for a lead series of S1P3-sparing, S1P1 agonists originally developed from a high-throughput screening campaign. This work describes the subsequent optimization of these leads by balancing potency, selectivity, solubility and overall molecular charge. Focused SAR studies revealed favorable structural modifications that, when combined, produced compounds with overall balanced profiles. The low brain exposure observed in rat suggests that these compounds would be best suited for the potential treatment of peripheral autoimmune disorders.
Archive | 2009
Brian Nicholas Cook; Darren Di Salvo; Christian Harcken; Daniel Kuzmich; Thomas Wai-Ho Lee; Pingrong Liu; John Lord; Can Mao; Jochen Neu; Brian Christopher Raudenbush; Hossein Razavi; Alan David Swinamer
Journal of Medicinal Chemistry | 2014
Christian Harcken; Doris Riether; Daniel Kuzmich; Pingrong Liu; Raj Betageri; Mark Ralph; Michel J. Emmanuel; Jonathan T. Reeves; Angela Berry; Donald Souza; Richard M. Nelson; Alison Kukulka; Tazmeen N. Fadra; Ljiljana Zuvela-Jelaska; Roger M. Dinallo; Jörg Bentzien; Gerald H. Nabozny; David S. Thomson
Bioorganic & Medicinal Chemistry Letters | 2006
Abdelhakim Hammach; Antonio J.M. Jr Ridgefield Barbosa; Faith Gaenzler; Tazmeen N. Fadra; Daniel R. Goldberg; Ming-Hong Hao; Rachel R. Kroe; Pingrong Liu; Kevin Chungeng Qian; Mark Ralph; Christopher Ronald Sarko; Fariba Soleymanzadeh; Neil Moss
Archive | 2004
Younes Bekkali; Rajashekhar Betageri; Michael J. Emmanuel; Abdelhakim Hammach; Christian Harcken; Thomas M. Kirrane; Daniel Kuzmich; Thomas Wai-Ho Lee; Pingrong Liu; Usha R. Patel; Hossein Razavi; Doris Riether; Hidenori Takahashi; David S. Thomson; Ji Wang; Renee M. Zindell; John R. Proudfoot
Archive | 2009
Brian Nicholas Cook; Christian Harcken; Thomas Wei-Ho Lee; Pingrong Liu; Jord Lord; Can Mao; Wang Mao; Brian Christopher Raudenbush; Hossein Razavi; Christopher Ronald Sarko; Alen David Swinamer
Archive | 2005
Richard M. Nelson; Pingrong Liu; John R. Proudfoot; Doris Riether; Christian Harcken; David S. Thomson
ACS Medicinal Chemistry Letters | 2014
Christian Harcken; Doris Riether; Pingrong Liu; Hossein Razavi; Usha R. Patel; Thomas Wai-Ho Lee; Todd Bosanac; Yancey David Ward; Mark Ralph; Zhidong Chen; Donald Souza; Richard M. Nelson; Alison Kukulka; Tazmeen Fadra-Khan; Ljiljana Zuvela-Jelaska; Mita Patel; David S. Thomson; Gerald H. Nabozny
Archive | 2011
Rajashekhar Betageri; Brian Nicholas Cook; Darren Disalvo; Christian Harcken; Daniel Kuzmich; Pingrong Liu; John Lord; Can Mao; Hossein Razavi
Archive | 2003
Antonio J.M. Jr Ridgefield Barbosa; Daniel R. Goldberg; Abdelhakim Hammach; Pingrong Liu; Neil Moss; Mark Ralph; Gregory P. Roth; Christopher Ronald Sarko; Fariba Soleymanzadeh; Andre White
