Pir Muhammad

Coumarinolignoid glycoside from Daphne oleoides

Abstract A new coumarinolignoid glycoside, daphneticin-4″-O-a- d -glucopyranoside, alongwith the known, daphneticin, have been isolated from the whole plant extract of Daphne oleoides. The structures of these compounds were elucidated on the basis of chemical and spectroscopicevidence.

Emodinol, ß-Glucuronidase Inhibiting Triterpene from Paeonia Emodi

Emodinol, a new oleane type triterpene, has been isolated from the chloroform soluble fraction of Paeonia emodi. The structure 1β, 3β, 23-trihydroxyolean-12-en-28-oic acid 1 has been assigned on the basis of spectral studies including 2D NMR. It showed significant β-glucuronidase inhibitory activity. In addition benzoic acid and 3-hydroxybenzoic acid have also been reported for the first time from this species.

Spinoside, new coumaroyl flavone glycoside from Amaranthus spinosus.

Spinoside, new coumaroyl flavone glycoside was isolated from then-butanol fraction of the mathanolic extract of the whole plant ofAmaranthus spinosus and assigned the structure 7-p-coumaroyl apigenin4-O-β-D-glucopyranoside (1) on the basis of spectroscopic techniques including 1D and 2D NMR spectroscopy. In addition α- xylofuranosyl uracil (2), β-D-ribofuranosyl adenine (3) and β-sitosterol glucoside (4) have also been isolated for the first time from this species.

Chemical Constituents of Ajuga parviflora

Two new antifungal withanolides, (1) and (2) have been isolated from the defatted methanolic extract of Ajuga parviflora. Their structures were established as 3β,17β,20-trihydroxy-1-oxo-(20R, 22R)-witha-5,14,24-trienolide (1), 28-hydroxy-14,20-epoxy-1-oxo-(22R)-witha-2,5,24-trienolide (2) on the basis of spectroscopic data including two dimensional NMR techniques. The pyrrolizidine alkaloids senecionine (3) and integerrimine (4) are also reported for the first time from A. parviflora

A pentacyclic triterpene from Daphne oleoides

Abstract From the whole plant extract of Daphne oleoides, a new triterpene and the known 20 (30)-lupene-3,29-diol, butilin, and stigmasterol glycoside have been isolated for the first time from this source. The new triterpene was established as lup-20 (30)-ene-3a, 29-diol on the basis of homonuclear 1H decoupled 13C, DEPT, 1H–13C HMQC, long range HMBC NMR spectral studies and by chemical methods.

NEW MONOTERPENE GLYCOSIDES FROM PAEONIA EMODI

Two new monoterpene glycosides, wurdin and benzoylwurdin along with known compounds, paeoniflorin. lactiflorin and oxypaeoniflorin have been isolated from Paeonia emodi. The identity of new compounds have been established by a combination of spectroscopic techniques and chemical transformations.

New acetylated quinols from Ajuga parviflora

Abstract Four quinols, 4-acetyloxy-4-(methylenecarboethoxy)-cyclohexa-2,5-dienone (1), 4-acetyloxy-4-(methylenecarbomethoxy)-cyclohexa-2,5-dienone (2), 4-hydroxy-4-(methylenecarboethoxy)-cyclohexa-2,5-dienone (3) and 4-hydroxy-4-(methylenecarbomethoxy)-cyclohexa-2,5-dienone (4) were isolated from Ajuga parviflora. Compounds 1–3 are new.

Structural determination of quercusides A and B, new flavonoid glucosides from Quercus incana, by 1D and 2D NMR spectroscopy

Quercusides A and B, new flavonoid glucosides have been isolated from the chloroform soluble fractions of Quercus incana. Their structures were assigned from 1H and 13C nuclear magnetic resonance spectra, distortionless enhancement by polarization transfer (DEPT) and by correlation spectroscopy, heteronuclear multiple quantum correlation (HMQC) and heteronuclear multiple bond correlation (HMBC) experiments. Lupeol, β‐sitosterol and ursolic acid have also been reported from this species. Copyright