Poonam Mothsra

Neat Reaction Technology for the Synthesis of Novel 1,5‐Benzodiazepines

Abstract A convenient, solvent‐free, green approach is described for the synthesis of novel 1,5‐benzodiazepines by the reaction of ethylacetoacetate, aldehyde, and o‐phenylenediamine without any catalyst at pH 7.

Green Enzymatic Synthesis of L-Ascorbyl Fatty Acid Ester: An Antioxidant

Abstract In green chemistry, biocatalysis using microwaves is a very attractive tool for various regioselective syntheses. L-Ascorbyl fatty acid esters were synthesized by an immobilized lipase from Bulkholderia multivorans using microwaves, with a dynamically enhanced rate of reaction and appreciable yield of around 80%. Microwave radiation had no effect on enzymic inactivation, however, synergism between microwaves and biocatalyst was observed.

N-acylation of ethanolamine using lipase: a chemoselective catalyst

Summary The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation.

Molecular iodine as a versatile reagent for Hantzsch synthesis of 2-aminothiazole derivatives

A simple and facile synthesis of 2-aminothiazoles has been accomplished using molecular iodine catalyzed condensation of bromoketones with thiourea. The advantage of this method is that pure products are formed very rapidly under mild conditions.

Microwave-assisted neat reaction technology for the synthesis of s-triazolo[3,4-b]-1,3,4-thiadiazines

An expeditious, solvent-free, and high yielding synthesis of nitrogen containing heterocycles from 1,2,4-s-triazole, benzoin, chloroacetic acid or phenacyl bromide under microwave irradiation is described. This improved greener synthetic methodology provides a simple and straightforward one-pot approach for the synthesis of a variety of heterocycles.