Pratibha Dwivedi

An efficient thiourea-based colorimetric chemosensor for naked-eye recognition of fluoride and acetate anions: UV-vis and 1HNMR studies.

An efficient colorimetric chemosensor with a thiourea binding site and 2-amino-6-nitrobenothiazole as a signaling unit has been synthesized by dithiocarbamate approach. The chemosensor has been utilized for selective recognition of fluoride and acetate anions in dry DMSO solution by UV-vis and (1)H NMR titration experiments. The chemosensor has shown naked-eye sensitivity for both the anions in solution.

Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates

AbstractThe 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with O-benzylquercetin alkynes (5–7) to afford regioselective triazole-linked O-benzylquercetin glycoconjugates (8–10) was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates (8–10) were evaluated for anti-leishmanial activity against the promastigotes and amastigotes of Leishmania donovani. Graphical AbstractClick Inspired Synthesis of Antileishmanial Triazolyl O-Benzylquercetin Glycoconjugates

Click inspired synthesis of triazole-linked vanillin glycoconjugates

AbstractThe 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with alkyne derivatives of p-vanillin, 3-methoxy-4-(prop-2-ynyloxy)benzaldehyde (2) and 2-methoxy-1-(prop-2-ynyloxy)-4-((prop-2-ynyloxy)methyl)benzene) (4) to afford regioselective triazole-linked vanillinglycoconjugates 5 and 6 was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates were characterized on the basis of IR, NMR, and MS. Graphical abstractTriazolyl vanillin glycoconjugates via click chemistry

Processing of wet Kinnow mandarin (Citrus reticulata) fruit waste into novel Brønsted acidic ionic liquids and their application in hydrolysis of sucrose

In citrus processing industries, where up to 60% of the whole fruit is discarded, generates citrus waste (peel, seeds, membrane, and pulp) on a massive scale. The waste does not currently have high-value applications, instead the majority is disposed of or pelletized for animal feed. Therefore, a concise and efficacious protocol for processing of Kinnow mandarin (Citrus reticulata) fruit waste to numerous novel Brønsted acidic ionic liquids (3a-k) have been developed. BAILs were characterized using spectroscopic techniques (FT-IR and NMR). Water immiscibility of ILs 3a, 3g and 3h, a property never observed with sulfonic acid ILs, allowed the catalytic application of BAIL 3a in hydrolysis of sucrose/table sugar, giving a mixture of d-glucose and d-fructose in excellent yields. The ionic liquid could be recycled for >3 times without significant loss of activity.

A probe for detection of G-rich target strands through fluorescence quenching

A modified fluorescent probe UFAA AAT CTC CGC CGC was synthesized using the nucleoside analogue 3′-O-(N,N′-diisopropylamino-2-cyanoethoxyphosphinyl)-5′-O-(4,4′-dimethoxytrityl)-2′-O-(dansyl-1-sulfonamidohexylaminocarbonyl)uridine for hybridization studies with perfectly matched (U/A) complementary DNA and with a DNA strand having similar G-rich telomeric units at their 3′-ends. Data on the thermal stability and decrease in fluorescence intensity due to the presence of dG units clearly demonstrated the potential application of this approach in DNA diagnostics in homogeneous hybridization assays.

Properties and important molecules of medicinal interest in wood apple (Aegle marmelos)

Abstract Aegle marmelos is a tree used for millennia in the Indian subcontinent and Indochina as a medicinal herb to treat myriad ailments. The ripe fruits are of dietary use, pulp is used to produce food products like jam, jelly, candy, squash, etc. In traditional system of medicine, A. marmelos fruit is prescribed for antibacterial, antiviral, antidiarrheal, gastroprotective, antiulcerative colitis, hepatoprotective, antidiabetic, cardioprotective and radioprotective effects.

Isolation of a new flavonoid and waste to wealth recovery of 6-O-Ascorbyl Esters from Seeds of Aegle marmelos (family- Rutaceae)

Abstract Aegle marmelos is a plant species native to India. Commercially available food products such as jam, jelly, candy, squash etc. are prepared from ripe fruit pulp of A. marmelos. Ripe fruit processing accounts for 60% of whole fruit mass while 40% remains unutilized and generates waste (hard shell, pomace, fiber and seeds) on a massive scale which do not have high value applications. A new flavone 3,5,7-trihydroxy-2-(4′-hydroxy-3′-isopentyloxyphenyl-4H-chromen-4-one (5) in addition to the known compounds 1–4, has been isolated from seeds of A. marmelos. Also, compound 7-(3′-methylbut-2′-enyloxy)-2H-chromen-2-one (2) has been isolated for the first time from A. marmelos. The structure of compounds 1–5 was determined by spectral analysis (UV, IR, NMR, etc.). Additionally, the non-edible oil obtained from seeds was investigated for waste to wealth recovery of 6-O-ascorbyl esters in high regioselectivity via one step semi-synthetic approach in the presence of ascorbic acid and H2SO4 at ambient temperature. Graphical Abstract