Qing-Bao Song

Rapid and Efficient Synthesis of 3,3-Di(1H-indol-3-yl)indolin-2-ones and 2,2-Di(1H-indol-3-yl)-2H-acenaphthen-1-ones Catalyzed by p-TSA

Abstract An efficient synthesis of 3,3-di(1H-indol-3-yl)indolin-2-ones and 2,2-di(1H-indol-3-yl)-2H-acenaphthen-1-ones via a reaction of various isatins or acenaphthenequinone with indoles in the presence of p-methylbenzene sulfonic acid (p-TSA) in CH2Cl2 at room temperature is described. The advantages of this method include good reaction yield, simple workup procedure, and mild reaction condition. GRAPHICAL ABSTRACT

Synthesis of novel chiral tridentate Schiff-base ligands and their applications in catalytic asymmetric Henry reaction.

A series of chiral tridentate Schiff-bases were prepared and used as ligands in the catalytic asymmetric Henry reaction. Under the optimal conditions, a variety of arylaldehydes were smoothly converted into corresponding adducts with high yields (up to 98%) and excellent enantioselectivities (up to 97% ee).

Asymmetric henry reaction catalyzed by chiral schiff base

Four chiral Schiff bases were synthesized conveniently from chiral amino alcohol and 2-hydroxynaphthalene-1-carbaldehyde. These ligands were used to catalyze the addition of nitroalkanes to aldehydes under ambient conditions in good yields with up to 91% ee.

Synthesis and Bioactivities of Clopyralid Hydrazide-Hydrazones

A series of clopyralid hydrazide-hydrazone derivatives (4a–p) have been synthesized. Their structures were confirmed by elemental analysis, infrared, and 1H NMR spectra. The bioactivities of compounds 4a–p were tested with barnyard grass, rape, and S. aureus, but the results showed that they could not be considered the promising herbicidal or antibacterial agents.

(2S,3S)-2,3-Dihydroxy­succinic acid monohydrate

The crystal structure of the title compound, C4H6O6·H2O, displays a two-dimensional network formed by O—H⋯O hydrogen bonds.

4′-Bromo­methyl­bi­phenyl-2-carbo­nitrile

In the title compound, C14H10BrN, the dihedral angle between the two aromatic rings is 48.34u2005(14)°. Weak C—H⋯Br and C—H⋯N interactions are the principal intermolecular forces.

2-[3-Acetyl-5-(3,6-dichloro­pyridin-2-yl)-2,3-dihydro-1,3,4-oxadiazol-2-yl]phenyl acetate

The title compound, C17H13Cl2N3O4, shows the substituted pyridine ring to be coplanar with the oxadiazoxadline ring but the third ring to be normal to this. Chains mediated by C—H⋯O interxadactions are linked to two other chains via C—H⋯Cl interxadactions and to another two chains via C—H⋯π interxadactions.

(E)-N′-(4-Chlorobenzylidene)-3,6-dichloropicolinohydrazide

The title compound, C13H8Cl3N3O, shows the substituted pyridine ring to be twisted by about 10° from the rest of the essentially planar molxadecule.

1-[5-(2-Chloropyridin-3-yl)-2-methyl-2-phenyl-1,3,4-oxadiazol-3(2H)-yl]ethanone

Allen, F. H., Kennard, O., Watson, D. G., Brammer, L., Orpen, A. G. & Taylor, R. (1987). J. Chem. Soc. Perkin Trans. 2, pp. S1–19. Bruker (2000). SMART, SAINT, SADABS and SHELXTL. Bruker AXS Inc., Madison, Wisconsin, USA. Hassan, E., Al-Ashmawi, M. I. & Abdel-Fattah, B. (1983). Pharmazie, 38, 833– 835. Khalil, M. A., El-Sayed, O. A. & El-Shamny, H. A. (1993). Arch. Pharm. (Weinheim), 326, 489–492. Sheldrick, G. M. (1997). SHELXS97 and SHELXL97. University of Göttingen, Germany. Song, Q.-B., Zhang, J., Dong, Y. & Tiekink, E. R. T. (2006). Acta Cryst. E62, o4388–o4390. Song, Q.-B., Zhang, J. & Tiekink, E. R. T. (2006). Acta Cryst. E62, o4115– o4117. organic compounds

1-[5-(3,6-Dichloro­pyridin-2-yl)-2,2-dimethyl-1,3,4-oxadiazol-3-yl]ethanone

The title compound, C11H11Cl2N3O2, shows an approximately planar oxadiazoxadline ring and a small twist between its two ring systems. In the crystal structure, molecules are linked into chains via C—H⋯O interactions and centrosymmetrically related chains are connected into double chains via weaker C—H⋯N interactions.