Qing-Wen Shi

Chemical and Pharmacological Research of the Plants in Genus Euphorbia

3.1. Biosynthesis from Jatrophanes 4313 3.2. Biosynthesis from Lathyranes 4314 4. Biological Activity 4314 4.1. Antiproliferative Activity 4314 4.2. Cytotoxicity 4316 4.3. Effects on the Cell Division 4316 4.4. DNA-Damaging Activity 4316 4.5. Modulatority of Multidrug Resistance 4316 4.6. Tumor Promoting Activity 4318 4.7. Pro-Inflammatory Activity 4318 4.8. Inhibition of Allergic Reactions 4318 4.9. Antimicrobial Activity 4319 4.10. Antidiarrheal Activity 4322 4.11. Antipyretic-Analgesic Activity 4322 4.12. Molluscicidal and Antifeedant Activities 4323 4.13. Inhibitory Activity on the Mammalian Mitochondrial Respiratory Chain 4323

Constituents from Salvia Species and Their Biological Activities

Yi-Bing Wu,† Zhi-Yu Ni,† Qing-Wen Shi,*,† Mei Dong,‡ Hiromasa Kiyota,* Yu-Cheng Gu,†,∥ and Bin Cong*,‡ †School of Pharmaceutical Sciences, Hebei Key Laboratory of Forensic Medicine, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China ‡Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Shijiazhuang, Hebei Province 050017, China Department of Bioscience and Biotechnology for Future Bioindustry, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan Syngenta Jealott’s Hill International Research Centre, Berkshire RG42 6EY, United Kingdom

Natural Taxanes: Developments Since 1828

Natural Taxanes: Developments Since 1828 Yu-Fang Wang, Qing-Wen Shi,* Mei Dong, Hiromasa Kiyota,* Yu-Cheng Gu, and Bin Cong* School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Shijiazhuang, Hebei Province, 050017, China Department of Bioscience and Biotechnology for Future Bioindustry, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan Syngenta Jealott’s Hill International Research Centre, Berkshire, RG42 6EY, U.K.

Chemical Constituents of the Plants from Genus Jatropha

by Xi-Ping Zhanga), Man-Li Zhanga), Xiao-Huo Sua), Chang-Hong Huoa), Yu-Cheng Gub), and Qing-Wen Shi*a) a) Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P. R. China (e-mail: shiqingwen@hebmu.edu.cn) b) Syngenta Jealott s Hill International Reasearch Centre, Bracknell, Berkshire RG426EY, UK

Echinopines A and B: sesquiterpenoids possessing an unprecedented skeleton from Echinops spinosus.

Echinopines A (1) and B (2), novel sesquiterpenoids with an unprecedented rearranged skeleton named echinopane, were isolated from the roots of Echinops spinosus. The structures were elucidated by extensive spectroscopic analysis. The relative configuration of 1 was assigned by a combination of NOESY correlations and a simulation analysis. A plausible biosynthetic pathway for echinopane was discussed.

Chemical Constituents of Plants from the Genus Eupatorium

by Man-Li Zhanga), Ming Wua), Jian-Jian Zhangb), Dianne Irwinc), Yu-Cheng Gu*a)c), and Qing-Wen Shi*a) a) Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P. R. China (phone: þ8631186265634; e-mail: shiqingwen@hebmu.edu.cn) b) Department of Pharmacy, Hospital of Chinese People5s Armed Police Forces Academy, 137 Aiming West Street, 065000, Lang Fang, Hebei Province, P. R. China c) Jealott5s Hill International Research Centre, Syngenta, Berkshire, RG426EY, UK

Chemical and pharmacological research on plants from the genus Senecio.

by Yan Yanga)b), Lei Zhaoa)b), Yu-Fang Wanga), Man-Li Changa), Chang-Hong Huoa), Yu-Cheng Gua)c), Qing-Wen Shi*a), and Hiromasa Kiyota*d) a) Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, P. R. China (phone: þ86-311-86265634; e-mail: shiqingwen@hebmu.edu.cn) b) The Tumor Hospital of Yunnan Province, the Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kunming 650118, P. R. China c) Jealott s Hill International Research Centre, Syngenta, Berkshire, RG426EY, UK d) Laboratory of Applied Bioorganic Chemistry, Division of Life Science, Graduate School of Agricultural Sciences, TohokuUniversity, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai, 981-8555, Japan (phone/fax: þ81-22-7178785; e-mail: kiyota@biochem.tohoku.ac.jp)

Secondary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

The Asteraceae family comprises ca. 1000 genera, mainly distributed in Asia and Europe. Saussurea DC., as the largest subgenus of this family, comprises ca. 400 species worldwide, of which ca. 300 species occur in China. Most plants in China grow wild in the alpine zone of the Qingzang Plateau and adjacent regions at elevations of 4000 m. Plants of the genus Saussurea (Asteraceae) are used in both traditional Chinese folk medicine and Tibet folklore medicine, since they are efficacious in relieving internal heat or fever, harmonizing menstruation, invigorating blood circulation, stopping bleeding, alleviating pain, increasing energy, and curing rheumatic arthritis. A large number of biologically active compounds have been isolated from this genus. This review shows the chemotaxonomy of these compounds (215 compounds) such as sesquiterpenoids (101 compounds), flavonoids (19 compounds), phytosterols (15 compounds), triterpenoids (25 compounds), lignans (32 compounds), phenolics (23 compounds), and chlorophylls (11 compounds). Biological activities (anti‐inflammatory, anticancer, antitumor, hepatoprotective, anti‐ulcer, cholagogic, immunosuppressive, spasmolytic, antimicrobial, antiparasitic, antifeedant, CNS depressant, antioxidant, etc.) of these compounds, including structure–activity relationships, are also discussed.

Chemical constituents of plants from the genus Illicium.

by Yun-Ning Liua), Xiao-Hui Sua), Chang-Hong Huoa), Xi-Ping Zhanga), Qing-Wen Shi*a), and Yu-Cheng Gub) a) Laboratory of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, Hebei Province, P. R. China (phone: þ86-311-86265634; e-mail: shiqingwen@hebmu.edu.cn) b) Syngenta Jealott s Hill International Reasearch Centre, Bracknell, Berkshire RG426EY, UK

Chemical and pharmacological studies of the plants from genus Celastrus.

The plants of genus Celastrus, distributed in Asia, have been used as natural insecticides and folk medicines to treat fever, chill, joint pain, edema, rheumatoid arthritis, and bacterial infection in China for a long time. This contribution reviews the chemical constituents, 1–144, isolated from the plants in genus Celastrus in the past few decades, and their biological activities. The compounds listed are sesquiterpenes (β‐agarofurans), diterpenes, triterpenes, alkaloids, and flavonoids.