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Qingping Tian

General Atomics

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Publication

Featured researches published by Qingping Tian.

Tetrahedron Letters | 2001

An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-l-(+)-glutamic acid dimethyl ester

Qingping Tian; Naresh Nayyar; Srinivasan Babu; Lijian Chen; Junhua Tao; Steven Lee; Anthony Tibbetts; Terence Moran; Jason Liou; Ming Guo; Timothy P Kennedy

Abstract An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc- l -(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogram quantities with an overall yield of 30%.

Organic Process Research & Development | 2015

A Practical, Protecting-Group-Free Synthesis of a PI3K/mTOR Inhibitor

Qingping Tian; Ursula Hoffmann; Theresa Humphries; Zhigang Cheng; Pirmin Hidber; Herbert Yajima; Maud Guillemot-Plass; Jane Li; Ulrike Bromberger; Srinivasan Babu; David Askin; Francis Gosselin

Organic Process Research & Development | 2006

A Simple Modification to Prevent Side Reactions in Swern-Type Oxidations Using Py·SO3

Lijian Chen; Steven Lee; Matt Renner; Qingping Tian; Naresh Nayyar

Organic Process Research & Development | 2013

A Practical Synthesis of a PI3K Inhibitor under Noncryogenic Conditions via Functionalization of a Lithium Triarylmagnesiate Intermediate

Qingping Tian; Zhigang Cheng; Herbert Yajima; Scott Savage; Keena Green; Theresa Humphries; Mark Reynolds; Srinivasan Babu; Francis Gosselin; David Askin; Isao Kurimoto; Norihiko Hirata; Mitsuhiro Iwasaki; Yasuharu Shimasaki; Takashi Miki

Archive | 2001

Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates

Qingping Tian; Naresh Nayyar; Srinivasan Babu; Junhua Tao; Terence Moran; Raymond Dagnino; Lennert J. Mitchell; Travis Remarchuk; Michael Melnick; Steven L. Bender

Tetrahedron-asymmetry | 2005

Chemoenzymatic synthesis of ketomethylene tripeptide isosteres

Junhua Tao; Shanghui Hu; Qingping Tian; Naresh Nayyar; Srin Babu

Archive | 2002

Efficient methods for the preparation of rhinovirus protease inhibitors, key intermediates and a continuous membrane reactor useful for preparing the same

Junhua Tao; Srinivasan Babu; Raymond Dagnino; Qingping Tian; Travis Remarchuk; Kevin McGee; Naresh Nayyar; Terence Moran

Archive | 2000

Process and intermediates for the preparation of isoxazolecaroxamides and analogues

Junhua Tao; Srinivasan Babu; Raymond Dagnino; Qingping Tian; Travis Remarchuk; Kevin Scott Mcgee; Naresh Nayyar; Terence Moran

Archive | 2017

processo de preparação, sal de oxalato de (s)-2-hidroxi-1-(piperazin-1-il)propan-1-ona e invenção

Francis Gosselin; Herbert Yajima; Pirmin Hidber; Qingping Tian; Reinhard Reents; Srinivasan Babu; Theresa Humphries; Ursula Hoffmann; Zhigang Cheng

Archive | 2016

Discovery and Process Development of Class I PI3K and Class I PI3K/mTOR Inhibitors GDC-0941 and GDC-0980

Srinivasan Babu; Francis Gosselin; Theresa Humphries; Alan G. Olivero; Daniel P. Sutherlin; Qingping Tian

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Srinivasan Babu

General Atomics

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Naresh Nayyar

General Atomics

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Junhua Tao

New Mexico State University

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Francis Gosselin

Genentech

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Terence Moran

General Atomics

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Herbert Yajima

Genentech

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Raymond Dagnino

Pfizer

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Travis Remarchuk

General Atomics

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Zhigang Cheng

Sumitomo Chemical

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Pirmin Hidber

Hoffmann-La Roche

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