Naresh Nayyar | Researchain

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Featured researches published by Naresh Nayyar.

Tetrahedron Letters | 2001

An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-l-(+)-glutamic acid dimethyl ester

Qingping Tian; Naresh Nayyar; Srinivasan Babu; Lijian Chen; Junhua Tao; Steven Lee; Anthony Tibbetts; Terence Moran; Jason Liou; Ming Guo; Timothy P Kennedy

Abstract An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc- l -(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogram quantities with an overall yield of 30%.

Journal of Medicinal Chemistry | 2003

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.

Peter S. Dragovich; Thomas J. Prins; Ru Zhou; Theodore Otto Johnson; Ye Hua; Hiep T. Luu; Sylvie K. Sakata; Edward L. Brown; Fausto C. Maldonado; Tove Tuntland; Caroline A. Lee; Shella A. Fuhrman; Leora S. Zalman; Amy K. Patick; David A. Matthews; Ellen Y. Wu; Ming Guo; Bennett C. Borer; Naresh Nayyar; Terence Moran; Lijian Chen; Paul A. Rejto; Peter W. Rose; Mark C. Guzman; Elena Z. Dovalsantos; Steven Lee; Kevin McGee; Michael Mohajeri; Andreas Liese; Junhua Tao

Archive | 2005

Polymorphic and amorphous forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-ce]indol-6-one

Jia Liu; Naresh Nayyar; Ming Guo; Zhen-Ping Wu; Bennett C. Borer; Aparna Nadig Srirangam; Mark Bryan Mitchell; Yi Li; Jan-Jon Chu

Organic Process Research & Development | 2006

A Simple Modification to Prevent Side Reactions in Swern-Type Oxidations Using Py·SO3

Lijian Chen; Steven Lee; Matt Renner; Qingping Tian; Naresh Nayyar

Archive | 2001

Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates

Qingping Tian; Naresh Nayyar; Srinivasan Babu; Junhua Tao; Terence Moran; Raymond Dagnino; Lennert J. Mitchell; Travis Remarchuk; Michael Melnick; Steven L. Bender

Tetrahedron-asymmetry | 2005