R. K. Lanza

Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein.

Transformed cells lack a large, external, transformation-sensitive (LETS) glycoprotein which is a major surface component of their normal counterparts. Addition of LETS glycoprotein isolated from normal cells to transfomed cells restores certain morphological features and adhesive properties characteristic of normal cells. LETS protein is detected on the cell surface both by iodination using lactoperoxidase and by immunofluorescent staining. The surface distribution pattern detected by immunofluorescence is strikingly similar to that of normal cells. After addition of LETS protein, transformed cells also exhibit well defined actin cables which are not seen in untreated, transformed cells. All these alterations can be blocked by treating LETS protein with specific antisera or by subjecting it to mild trypsinization prior to addition to transformed cells. The effects are rapidly reversible by mild trypsinization, which removes the added LETS protein. The high rate of uptake of 2-deoxyglucose, characteristic of transformed cells, is not affected by LETS protein. These results suggest that LETS protein may have a role in cell attachment and spreading, and affect the organization of cytoskeleton.

The Holometer: An instrument to probe Planckian quantum geometry

This paper describes the Fermilab Holometer, an instrument for measuring correlations of position variations over a four-dimensional volume of space-time. The apparatus consists of two co-located, but independent and isolated, 40 m power-recycled Michelson interferometers, whose outputs are cross-correlated to 25 MHz. The data are sensitive to correlations of differential position across the apparatus over a broad band of frequencies up to and exceeding the inverse light crossing time, 7.6 MHz. A noise model constrained by diagnostic and environmental data distinguishes among physical origins of measured correlations, and is used to verify shot-noise-limited performance. These features allow searches for exotic quantum correlations that depart from classical trajectories at spacelike separations, with a strain noise power spectral density sensitivity smaller than the Planck time. The Holometer in current and future configurations is projected to provide precision tests of a wide class of models of quantum geometry at the Planck scale, beyond those already constrained by currently operating gravitational wave observatories.

MHz gravitational wave constraints with decameter Michelson interferometers

A new detector, the Fermilab Holometer, consists of separate yet identical 39-meter Michelson interferometers. Strain sensitivity achieved is better than

Interferometric Constraints on Quantum Geometrical Shear Noise Correlations

10^{-21} /{\sqrt{\rm{Hz}}}

First Measurements of High Frequency Cross-Spectra from a Pair of Large Michelson Interferometers

between 1 to 13 MHz from a 130-hr dataset. This measurement exceeds the sensitivity and frequency range made from previous high frequency gravitational wave experiments by many orders of magnitude. Constraints are placed on a stochastic background at 382 Hz resolution. The 3

Radiation-pressure-mediated control of an optomechanical cavity

\sigma

Experimental Limits on Gravitational Waves in the MHz Frequency Range with the Fermilab Holometer

upper limit on

Frequency stabilization of a laser used to measure Plank scale indeterminacy

\Omega_{\rm{GW}}