R. Neher
Ciba Specialty Chemicals
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Featured researches published by R. Neher.
Cellular and Molecular Life Sciences | 1953
S. A. Simpson; J. F. Tait; A. Wettstein; R. Neher; J. v. Euw; T. Reichstein
A new crystalline compound has been isolated from beef adrenal extracts. In three different assay methods using epinephrectomised rats or dogs it was found to be from 30 to 100 times as potent as cortexone (11-deoxy-corticosterone) or its acetate.
Journal of Chromatography A | 1963
E. von Arx; R. Neher
A novel multidimensional technique has been elaborated and found suitable for the chromatographic identification of 52 amino acids. This technique is based on three two-dimensional cellulose thine-layer chromatograms using the same solvent system for the first dimension and three different systems of suitable properties for the second dimension. With this method all amino acids can be differentiated and characterized by fixed positions, and in addition by some colour reactions. The relative merits of cellulose and silicagel as carriers are discussed in relation to separation efficiency, reproducibility and sensitivity of detection.
Cellular and Molecular Life Sciences | 1954
S. A. Simpson; J. F. Tait; A. Wettstein; R. Neher; J. v. Euw; O. Schindler; T. Reichstein
Chemical degradation of the new crystalline mineralocorticoid provisionally called electrocortin has shown that this compound is 11β, 21-dihydroxy-3, 20-diketo-4-pregnen-18-al. In solution this reacts mainly as the 11-hemiacetal. We suggest aldosterone as a definitive name for the compound.
Cellular and Molecular Life Sciences | 1961
F. W. Kahnt; R. Neher; K. Schmid; A. Wettstein
The transformation of Δ5-pregnenolone into 17α-hydroxy-Δ5-pregnenolone, and of the latter into DHA, is shown to occur in homogenates and fractions thereof, both of bovine adrenal and testicular tissue. The relative significance of these reactions for the biogenesis of androgens in normal and neoplastic tissue is discussed.
Cellular and Molecular Life Sciences | 1965
R. Neher; F. W. Kahnt
Der Seitenkettenabbau von C21-Steroiden zu Androgenen in Rattentesteshomogenat erwies sich abhängig von der Konzentration der Vorstufen und konnte durch gewisse Pyridinderivate präferentiell blockiert werden.
Cellular and Molecular Life Sciences | 1955
F. W. Kahnt; R. Neher; A. Wettstein
Cortexone labeled in the 21-position with C14 yielded radioactive Aldosterone through incubation with beef adrenal homogenate. Its activity, due entirely to the 21 carbon atom, showed that about 48% of the Aldosterone had arisen from a direct conversion of cortexone without intermediate degradation. The low yield by weight in this conversion suggests, however, that cortexone is not the only natural precursor for Aldosterone in the adrenal. The radioactivity of the corticosterone obtained showed that about 84% of it originated from added cortexone. Lack of radioactivity of the hydrocortisone confirmed that it does not essentially result from cortexone.
Cellular and Molecular Life Sciences | 1952
F. W. Kahnt; Ch. Meystre; R. Neher; E. Vischer; A. Wettstein
New observations on the necessary cofactors for the hydroxylation of steroids using adrenal homogenates are described. By microbiological hydroxylation of steroids preferably in 11α-position using molds i. a. the new 11-epimers of corticosterone and 17-hydroxy-corticosterone have been obtained. They are lacking high mineralocorticoidal activity.
Cellular and Molecular Life Sciences | 1961
R. Neher; G. Stark
The occurrence of cortisol, cortisone, 20-dihydrometabolites of cortisone and several other steroidlike compounds in fresh placental tissue is described. Neither aldosterone, corticosterone nor 11-dehydrocorticosterone has been found. One of the most abundant compounds present has been identified as 16α-hydroxy-testosterone.
Journal of Chromatography A | 1966
E. von Arx; R. Neher
Zusammenfassung Bau und Funktion einiger Hilffsmittel fur die Dunnschicht-chromatographie (DC) wurden beschrieben: Streichgerat fur die Herstellung gleichmassiger dunner und dicker Schichten; Hilfsmittel zur Vorprufung fur die praparative DC; Substanz-Applikator fur die praparative DC auf langen Platten.
Helvetica Chimica Acta | 1954
S. A. Simpson; J. F. Tait; A. Wettstein; R. Neher; J. v. Euw; O. Schindler; T. Reichstein