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Dive into the research topics where R. Nijveldt is active.

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Featured researches published by R. Nijveldt.


Netherlands Heart Journal | 2008

‘No-reflow’ after acute myocardial infarction: direct visualisation of microvascular obstruction by gadolinium-enhanced CMR

R. Nijveldt; A.M. Beek; A. Hirsch; M.B.M. Hofman; Victor A. Umans; Paul R. Algra; A. C. Van Rossum

Cardiovascular magnetic resonance is considered the standard imaging modality in clinical trials to monitor patients after acute myocardial infarction. However, limited data are available with respect to infarct size, presence and extent of microvascular injury (MVO) and changes over time, in relation to cardiac function in optimally treated patients. In the current study we prospectively investigate the change of infarct size over time, and the incidence and significance of MVO in a uniform, optimally treated patient group after AMI. (Neth Heart J 2008;16:179-81.)


PLOS ONE | 2017

Changes in remote myocardial tissue after acute myocardial infarction and its relation to cardiac remodeling: A CMR T1 mapping study

Paul S. Biesbroek; Raquel P. Amier; P.F.A. Teunissen; M.B.M. Hofman; Lourens Robbers; P.M. van de Ven; A.M. Beek; A. C. Van Rossum; N. van Royen; R. Nijveldt

Objectives To characterize the temporal alterations in native T1 and extracellular volume (ECV) of remote myocardium after acute myocardial infarction (AMI), and to explore their relation to left ventricular (LV) remodeling. Methods Forty-two patients with AMI successfully treated with primary PCI underwent cardiovascular magnetic resonance after 4–6 days and 3 months. Cine imaging, late gadolinium enhancement, and T1-mapping (MOLLI) was performed at 1.5T. T1 values were measured in the myocardial tissue opposite of the infarct area. Myocardial ECV was calculated from native- and post-contrast T1 values in 35 patients, using a correction for synthetic hematocrit. Results Native T1 of remote myocardium significantly decreased between baseline and follow-up (1002 ± 39 to 985 ± 30ms, p<0.01). High remote native T1 at baseline was independently associated with a high C-reactive protein level (standardized Beta 0.32, p = 0.04) and the presence of microvascular injury (standardized Beta 0.34, p = 0.03). ECV of remote myocardium significantly decreased over time in patients with no LV dilatation (29 ± 3.8 to 27 ± 2.3%, p<0.01). In patients with LV dilatation, remote ECV remained similar over time, and was significantly higher at follow-up compared to patients without LV dilatation (30 ± 2.0 versus 27 ± 2.3%, p = 0.03). Conclusions In reperfused first-time AMI patients, native T1 of remote myocardium decreased from baseline to follow-up. ECV of remote myocardium decreased over time in patients with no LV dilatation, but remained elevated at follow-up in those who developed LV dilatation. Findings from this study may add to an increased understanding of the pathophysiological mechanisms of cardiac remodeling after AMI.


Eurointervention | 2017

Effects of successful percutaneous coronary intervention of chronic total occlusions on myocardial perfusion and left ventricular function

Wynand J. Stuijfzand; Paul S. Biesbroek; Pieter G. Raijmakers; Roel S. Driessen; Stefan P. Schumacher; P.A. Van Diemen; Jeffery van den Berg; R. Nijveldt; Adriaan A. Lammertsma; S.J. Walsh; C.G. Hanratty; J.C. Spratt; A. C. Van Rossum; A. Nap; N. van Royen; Paul Knaapen

AIMSnThe aim of the present study was to investigate the effects of successful PCI CTO on absolute myocardial blood flow (MBF) and functional recovery.nnnMETHODS AND RESULTSnPatients with a documented CTO were prospectively examined for ischaemia and viability with [15O]H2O positron emission tomography (PET) and late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR). Sixty-nine consecutive patients, in whom PCI was successful, underwent follow-up PET and CMR after approximately 12 weeks to evaluate potential improvement of MBF as well as systolic function. After PCI, stress MBF in the CTO area increased from 1.22±0.36 to 2.40±0.90 mL·min-1·g-1 (p<0.001), whilst stress MBF in the remote area also increased significantly between baseline and follow-up PET (2.58±0.68 to 2.77±0.77 mL·min-1·g-1, p=0.01). The ratio of stress MBF between CTO and remote area was 0.49±0.13 at baseline and increased to 0.87±0.24 at follow-up (p<0.001). The MBF defect size of the CTO area decreased from 5.12±1.69 to 1.91±1.75 myocardial segments after PCI (p<0.001). Left ventricular ejection fraction (LVEF) increased significantly (46.4±11.0 vs. 47.5±11.4%, p=0.01) at follow-up.nnnCONCLUSIONSnThe vast majority of CTO patients with documented ischaemia and viability showed significant improvement in stress MBF and a reduction of ischaemic burden after successful percutaneous revascularisation with only minimal effect on LVEF.


Eurointervention | 2017

Microvascular dysfunction following ST-elevation myocardial infarction and its recovery over time

Mariëlla E.C.J. Hassell; Matthijs Bax; M.A. van Lavieren; R. Nijveldt; A. Hirsch; Lourens Robbers; Koen M. Marques; J. G. P. Tijssen; F. Zijlstra; A. C. Van Rossum; R. Delewi; Jan J. Piek

AIMSnIt is unclear whether microvascular dysfunction following ST-elevation myocardial infarction (STEMI) is prognostic for long-term left ventricular function (LVF), and whether recovery of the microvasculature status is associated with LVF improvement. The aim of this study was to assess whether microvascular dysfunction in the infarct-related artery (IRA), as assessed by coronary flow reserve (CFR) within one week after PPCI, was associated with LVF at both four months and two years.nnnMETHODS AND RESULTSnIn 62 patients, CFR and hyperaemic microvascular resistance index (HMRI) in the IRA were assessed by intracoronary Doppler flow measurements within one week and at four months. CMR was performed at the same time points and also at two years. CFR at baseline was associated with left ventricular ejection fraction (LVEF) at four months (β=4.66, SE=2.10; p=0.03) and at two-year follow-up (β=5.84, SE=2.45; p=0.02). HMRI was not associated with LVF. In large infarcts, absolute improvement of CFR in the first four months was associated with LVEF improvement (β=5.09, SE=1.86, p=0.01).nnnCONCLUSIONSnMicrovascular dysfunction, assessed by CFR, in the subacute phase of STEMI is prognostic for LVEF at four months and two years. This underlines the pivotal role of microvascular dysfunction following STEMI.


Netherlands Heart Journal | 2007

Double aortic arch

R. Nijveldt; Tjeerd Germans; A.M. Beek; Marco J.W. Götte; A. C. Van Rossum

SamenvattingA 58-year-old male was referred to our outpatient cardiology clinic for evaluation of atrial fibrillation, fatigue, dizziness and exertional dyspnoea. He had suffered recurrent pneumonia in childhood. Beside an irregular pulse, the physical examination was normal. Electrocardiography showed atrial fibrillation (ventricular response of 60 to 70 beats/min), a right bundle branch block and nonspecific repolarisation abnormalities. Pulmonary vascular redistribution was visible on chest X-ray (figure 1).


European Heart Journal | 2018

Timing of revascularization in patients with transient ST-segment elevation myocardial infarction: a randomized clinical trial

Jorrit S. Lemkes; Gladys N. Janssens; Nina van der Hoeven; Peter M. van de Ven; Koen M. Marques; Alexander Nap; Maarten A H van Leeuwen; Yolande Appelman; Paul Knaapen; Niels J W Verouden; Cornelis P. Allaart; Stijn L. Brinckman; Colette E Saraber; Koos J Plomp; Jorik R. Timmer; Elvin Kedhi; Renicus S. Hermanides; Martijn Meuwissen; Jeroen Schaap; Arno P. van der Weerdt; Albert C. van Rossum; R. Nijveldt; Niels van Royen

AimsnPatients with acute coronary syndrome who present initially with ST-elevation on the electrocardiogram but, subsequently, show complete normalization of the ST-segment and relief of symptoms before reperfusion therapy are referred to as transient ST-segment elevation myocardial infarction (STEMI) and pose a therapeutic challenge. It is unclear what the optimal timing of revascularization is for these patients and whether they should be treated with a STEMI-like or a non-ST-segment elevation myocardial infarction (NSTEMI)-like invasive approach. The aim of the study is to determine the effect of an immediate vs. a delayed invasive strategy on infarct size measured by cardiac magnetic resonance imaging (CMR).nnnMethods and resultsnIn a randomized clinical trial, 142 patients with transient STEMI with symptoms of any duration were randomized to an immediate (STEMI-like) [0.3u2009h; interquartile range (IQR) 0.2-0.7u2009h] or a delayed (NSTEMI-like) invasive strategy (22.7u2009h; IQR 18.2-27.3u2009h). Infarct size as percentage of the left ventricular myocardial mass measured by CMR at day four was generally small and not different between the immediate and the delayed invasive group (1.3%; IQR 0.0-3.5% vs. 1.5% IQR 0.0-4.1%, Pu2009=u20090.48). By intention to treat, there was no difference in major adverse cardiac events (MACE), defined as death, reinfarction, or target vessel revascularization at 30u2009days (2.9% vs. 2.8%, Pu2009=u20091.00). However, four additional patients (5.6%) in the delayed invasive strategy required urgent intervention due to signs and symptoms of reinfarction while awaiting angiography.nnnConclusionnOverall, infarct size in transient STEMI is small and is not influenced by an immediate or delayed invasive strategy. In addition, short-term MACE was low and not different between the treatment groups.


Esc Heart Failure | 2018

Strain imaging to predict response to cardiac resynchronization therapy: a systematic comparison of strain parameters using multiple imaging techniques: Strain imaging techniques in cardiac resynchronization therapy

Alwin Zweerink; Wouter M. van Everdingen; R. Nijveldt; Odette A.E. Salden; Mathias Meine; Alexander H. Maass; Kevin Vernooy; Frederik J. De Lange; Marc A. Vos; Pierre Croisille; Patrick Clarysse; Bastiaan Geelhoed; Michiel Rienstra; Isabelle C. Van Gelder; Albert C. van Rossum; M. J. Cramer; Cornelis P. Allaart

Various strain parameters and multiple imaging techniques are presently available including cardiovascular magnetic resonance (CMR) tagging (CMR‐TAG), CMR feature tracking (CMR‐FT), and speckle tracking echocardiography (STE). This study aims to compare predictive performance of different strain parameters and evaluate results per imaging technique to predict cardiac resynchronization therapy (CRT) response.


European Heart Journal | 2017

P866Effects of successful percutaneous coronary intervention of chronic total occlusions on myocardial perfusion and left ventricular function

Stefan P. Schumacher; Wynand J. Stuijfzand; Paul S. Biesbroek; Pieter G. Raijmakers; Roel S. Driessen; P.A. Van Diemen; R. Nijveldt; Adriaan Lammertsma; A. C. Van Rossum; A. Nap; N. van Royen; Paul Knaapen


European Heart Journal | 2017

294Long-term prognosis of silent myocardial infarction detected by LGE-CMR in patients presenting with first acute myocardial infarction

Raquel P. Amier; Martijn W. Smulders; Sebastiaan C.A.M. Bekkers; Sebastiaan T. Roos; P.F.A. Teunissen; Yolande Appelman; N. van Royen; W.M. van der Flier; A. C. Van Rossum; R. Nijveldt


European Heart Journal | 2018

P4677Segmental strain predicts functional recovery incremental to infarct in patients with a concurrent chronic total occlusion after primary percutaneous coronary intervention for STEMI

Joëlle Elias; I M Van Dongen; Loes P. Hoebers; Dagmar M. Ouweneel; Bimmer E. Claessen; Truls Råmunddal; Peep Laanmets; Erlend Eriksen; Jan J. Piek; R.J. Van Der Schaaf; Dan Ioanes; R. Nijveldt; J. G. P. Tijssen; José P.S. Henriques; Alexander Hirsch; Explore investigators

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N. van Royen

VU University Medical Center

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A.M. Beek

VU University Medical Center

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Paul Knaapen

VU University Medical Center

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A. Hirsch

Academic Medical Center

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Jan J. Piek

University of Amsterdam

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P.F.A. Teunissen

VU University Medical Center

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A. Nap

VU University Medical Center

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F. Zijlstra

Erasmus University Rotterdam

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