Rafael Albagli

Estudo da linfadenectomia radical comparada à linfadenectomia standard no tratamento cirúrgico do adenocarcinoma da papila de Vater

OBJECTIVE To evaluate the morbidity and mortality in patients undergoing surgical pancreatoduodenectomy (PD) in standard and radical lymphadenectomy for adenocarcinoma of papilla, analyzing the prognostic factors related to overall and disease-free survival. METHODS Were analyzed retrospectively from 1999 to 2007, in the Department of Abdominal and Pelvic Surgery (INCa-RJ), 50 cases of PD for adenocarcinoma of the duodenal papilla divided into two groups according to lymphadenectomy (group A: standard lymphadenectomy and group B: radical lymphadenectomy). RESULTS The median age was similar in both groups, as well as the distribution between the sex. In the comparison between the lymphadenectomies, only the number of lymph nodes resected (group A: 12.3 and group B: 26.5) and operative time (group A: 421 and group B: 474) were significantly different. There were no statistically significant differences in the two groups with respect to morbidity and mortality rate and length of hospitalization. The disease-free survival (group A: 35 months and group B: 51 months) and overall survival (group A: 38 months and group B: 53 months) was higher in the group of radical lymphadenectomy, but were not statistically significant. CONCLUSION In this study there were no cases of metastatic lymph nodes to other groups without nodal involvement of the pancreatic-duodenal lymph node chains (13, 17), suggesting a pattern of lymph node spread. Despite the radical lymphadenectomy present rates of disease-free survival and overall survival largest such data were not statistically significant. Further studies should be conducted to evaluate the real role of radical lymphadenectomy in adenocarcinoma of the duodenal papilla.

Emprego da anastomose pancreatojejunal tipo ducto-mucosa sem cateter transanastomótico em pâncreas de consistência mole e ducto fino: experiência inicial do Instituto Nacional de Câncer

BACKGROUND: Our goal is to report the morbimortality associated to the pancreatic reconstruction technique using duct-to-mucosa nonstented pancreatojejunostomy in soft pancreas and Wirsungs duct less than 3 mm. METHODS: We analyzed 16 consecutive patients submitted to DP with duct-to-mucosa pancreatojejunostomy technique in the Service of Abdominal-pelvic Surgery of NCI-Brazil. All patients had soft pancreatic texture and small pancreatic duct (< 3mm). RESULTS: From those 16 patients, eight were males, with an mean age of 55 years old. In the post-operative period one patient developed pancreatic fistula. There had been one death. CONCLUSION: We believe that duct-to-mucosa nonstented pancreatojejunostomy is possible in patients with pancreatic duct less than three mm and soft texture pancreas without increased morbimortality.

Gastroduodenopancreatectomia ampliada para tumores não periampulares

BACKGROUND: To evaluate the surgical morbimortality and the outcome of patients submitted to extended duodenopancreatectomy (DP) for nonperiampulary tumors. METHODS: A retrospective evaluation of 15 patients submitted to DP for nonperiampulary tumors was performed in the abdominal-pelvic surgery service of National Cancer Institute- Brazil, from 1990 to 2005. RESULTS: The histological types of primary tumors included adenocarcinoma of colon (n=9), gastric adenocarcinoma (n=3), gastrointestinal stromal tumors (n=2) and renal carcinoma (n=1). The average hospital length of stay was 13.5 days (6 to 36), the average operation time was 360 minutes, the hemotransfusion average volume was 307 ml, the ressected lymph nodes average number was 19, where 3 patients had positive lymph nodes. The average size of the tumor was 7.8cm (2.5 to 24), the surgical morbidity was 53%, the operative mortality was 6.6% (one patient) and the overall survival average was 38 months. CONCLUSION: The duodenopancreatectomy for nonperiampulary tumors is an procedure of exception and it must be considered only for selected patients.

Morbimortalidade relacionada à técnica de anastomose pancreática (ducto-mucosa x telescopagem) após cirurgia de Whipple

BACKGROUND: Pancreaticoduodenectomy has been used as a safe and appropriate surgical option in selected patients with malignant and benign disorders of the pancreas and periampullary region. Among the complications of the pancreatoduodenectomy, pancreatic anastomosis failure is the most important and sometimes fatal complication. According to recent reports, the incidence of leakage of pancreatic anastomosis after PD is high (between 5% and 25%). Our objectives were to analize the morbidity and mortality rates related to pancreatic anastomosis technique (duct-to-mucosa VS. telescopic) and to compare the results. METHODS: From January 1987 to December 2002, 64 patients underwent pancreaticoduodenal resection at Brazilian National Cancer Institute. Data were recorded retrospectively on all patients. Forty-two patients underwent pancreatojejunostomy duct-to-mucosa and the telescopic technique was performed in 22 patients. Statistical analyses were performed using the Fischers test. RESULTS: The pancreatic fistula rate after pancreatojejunostomy duct-to-mucosa and telescopic technique was 12% and 36%, respectively (p = 0.02). The operative mortality rate after duct-to-mucosa technique was 12% and 36% after pancreatojejunostomy telescopic (p = 0.4). CONCLUSIONS: The leakage rate was significantly lower in patients underwent to pancreatojejunostomy duct-to-mucosa, however an operative mortality rate was not significantly different between the two groups.

Cirurgia de resgate no carcinoma de canal anal

OBJETIVOS: Avaliar a sobrevida dos pacientes portadores de carcinoma epidermoide do canal anal submetidos a cirurgia de resgate, por recidiva ou falha do tratamento radioquimioterapico inicial. METODO: Analise retrospectiva dos pacientes portadores de carcinoma epidermoide do canal anal submetidos a cirurgia de resgate, de outubro de 1986 a setembro de 2000. RESULTADOS: Foram matriculados 93 pacientes portadores de carcinoma epidermoide do canal anal no periodo, e 21 (22,5%) foram submetidos a resgate cirurgico. Em 19 pacientes (91%) foi realizada amputacao abdominoperineal do reto (operacao de Miles), em um paciente exenteracao pelvica total e em um paciente excisao local. Nao houve mortalidade operatoria. A sobrevida media do grupo apos resgate cirurgico foi de 24 meses. CONCLUSOES: Apos recidiva e/ou falha da radioquimioterapia, a cirurgia de resgate e importante no controle locorregional do carcinoma epidermoide do canal anal.