Rafaella Bastos Leite

Matrix metalloproteinase‐8 levels in periodontal disease patients: A systematic review

Periodontal disease is characterized as a disorder of the oral microbiota resulting in an immune response which, in turn, leads to the destruction of periodontal tissue. Matrix metalloproteinase-8 (MMP-8) has been reported as the major metalloproteinase involved in periodontal disease, being present at high levels in gingival crevicular fluid and salivary fluid (SF). The aim of this systematic review was to evaluate the scientific literature regarding the expression of MMP-8 in gingival crevicular fluid and SF in patients with periodontal disease, analyzing its validity as a possible biomarker in the diagnosis of periodontal disease. A systematic review of the literature was performed using the PubMed/Medline, CENTRAL and Science Direct databases. Studies concerning the use of MMP-8 in the diagnosis of periodontal disease that evaluated its effectiveness as a biomarker for periodontal disease were selected. The search strategy provided a total of 6483 studies. After selection, six articles met all the inclusion criteria and were included in the present systematic review. The studies demonstrated significantly higher concentrations of MMP-8 in patients with periodontal disease compared with controls, as well as in patients presenting more advanced stages of periodontal disease. The findings on higher MMP-8 concentrations in patients with periodontal disease compared with controls imply the potential adjunctive use of MMP-8 in the diagnosis of periodontal disease.

Matrix metalloproteinase-8 analysis in patients with periodontal disease with prediabetes or type 2 diabetes mellitus: A systematic review

OBJECTIVESnThe objective of this systematic review was to evaluate information on the levels of MMP-8 in patients diagnosed with prediabetes or type 2 diabetes mellitus with periodontal disease, analyzing its validity as a possible biomarker for the diagnosis and progression of periodontal disease (PD).nnnMETHODSnA systematic search of the following databases was performed: PubMed/Medline, CENTRAL (The Cochrane Library), EMBASE and Web of Science. Studies involving the evaluation of MMP-8 in patients with prediabetes or patients presenting type 2 diabetes mellitus concomitantly with PD were selected. The evaluation of the methodological quality of the selected studies was based on the methodological bias risk analysis (QUADAS-2).nnnRESULTSnEight of the initially identified 2683 articles were selected. In all the selected studies, evaluator calibration and the use of clear methods for patient diagnosis with periodontal disease were present. Studies have demonstrated significantly higher MMP-8 concentrations in PD patients compared to controls, as well as in patients presenting more advanced stages of PD. However, controversies regarding MMP-8 levels in prediabetes/diabetes type 2 patients with PD.nnnCONCLUSIONSnHigher MMP-8 levels in patients with PD compared to controls imply the potential use of MMP-8 in the diagnosis of PD. The influence of patient glycemic state, as well as medications these patients make use of, are factors that possibly contribute to the modulation of MMP-8 concentrations in patients with diabetes and should be analyzed, aiming at a better understanding of the relationship between glycemic state and MMP-8 levels in patients with PD.

Cisto linfoepitelial em língua: relato de caso em localização incomum

Oral lymphoepithelial cyst (OLEC) is an uncommon lesion that develops in oral lymphoid tissue. The aim of the present study was to report a clinical case of OLEC in the tongue. A 22-year-old patient presented a nodular lesion, yellowish, with a softened consistency, measuring 0.5 cm in the ventral surface of the tongue. Under the clinical hypotheses of mucocele and OLEC, excisional biopsy was performed. The histopathological examination revealed a cystic lesion covered by a parakeratinized stratified squamous epithelium, which presented in its fibrous capsule a prominent lymphoid tissue. Based on the definitive diagnosis, surgical excision of the lesion was performed.

Eagle's Sydrome: Diagnosis and Incidence in a Brazilian Population

288 Objetivo: estabelecer a incidência da síndrome de Eagle (SE) no curso de Odontologia da Universidade de Fortaleza durante o período de três anos. Materiais e métodos: foram analisadas 945 radiografias panorâmicas. A avaliação foi realizada por dois examinadores em ambiente sem iluminação e com a utilização de negatoscópio. Um paquímetro digital foi utilizado para a mensuração dos casos com alongamento do processo estiloide, sendo considerados alongados os casos a partir de 30 mm. Resultados: das 945 radiografias analisadas, notou-se crescimento do processo estiloide superior a 30 mm em 75 panorâmicas (7,9%), sendo 51 (68%) mulheres e 24 (32%) de homens. Em 43 casos (57,3%), o alongamento foi encontrado bilateralmente, em 23 casos (30,7%) foi encontrado apenas no lado esquerdo e em 9 casos (12%) apenas no lado direito. Os 75 pacientes que possuíam o alongamento do osso foram submetidos a um questionário semiestruturado e 11 pacientes relataram sintomatologia dolorosa, com frequência variável de surgimento da dor. Uma detalhada anamnese e um exame físico desses pacientes permitiram o diagnóstico da SE em quatro deles. Conclusão: o trauma na região craniofacial foi o fator etiológico mais evidente nos pacientes diagnosticados com a SE. Os sinais e sintomas inerentes à SE eram semelhantes aos observados nas desordens craniomandibulares, podendo ocasionar falsos diagnósticos e tratamentos equivocados.