Rahime İnci

Dermatological aspects of synthetic cannabinoid addiction

Abstract Context: Synthetic cannabinoids (SCs) have recently become one of the most abused substances among young population and have caused severe health consequences in our country and worldwide. Objective: The aim of this study was to investigate sociodemographic and dermatological findings in SC addicts. Materials and methods: A total of 136 SC users who applied to our hospital’s Substance Dependence Center outpatient clinic and diagnosed with drug addiction according to DSM-4 criteria between September 2014 and September 2015 were enrolled to our study. Patients were evaluated by dermatologist and psychiatrist with sociodemographic and clinical data sheets. Data were obtained by direct conversation with patients, clinical examination findings, and laboratory tests, if necessary. Results: Of 136 patients, 12 (8.8%) were female and 124 (91.2%) were male, aged between 17 and 53 with mean age of 25.8 ± 9.2. Most common use way of SC was smoking and patients majorly used opiates before SC. The majority of the patients enrolled to our study were low-educated and almost 50% did not have a regular job. The most frequent dermatologic complaints were periorbital darkening, hallowed-cheeks and premature aging, hair loss and gray hair, and acnes, whereas most frequent dermatologic examination findings were artifact lesions such as blade scars and tobacco scars-stains, tattoos, and acnes. Discussion and conclusions: Given the increased prevalence of SC use in our country and around the world, dermatologists should continue to familiarize themselves with the common mucocutaneous markers of this substance use. Awareness of signs of SCs use will facilitate earlier diagnose, intervention, and directed treatment.

Case report of a patient with osteopoikilosis

Osteopoikilosis (OPK) is an uncommon osteosclerotic dysplasia. There is no exact evidence of its etiology and pathogenesis. Usually, it is an asymptomatic disease, and the diagnosis is made incidentally from radiographs, which show multiple, small, well-defined, variably shaped and widely distributed sclerotic areas over the skeleton. In this study, we report a 54-year-old man who suffers from back and leg pain and was diagnosed OPK by radiologically and review literature.

A very rare side effect of mitomycin-C: psoriasiform drug eruption

Various topical preparations have been used with variable success, including topical steroids, calcineurin inhibitors, retinoids, and clindamycin. Oral contraceptives and oral isotretinoin have also been used, but none produced long-lasing results, and lesions tend to recur once treatment is stopped. Physical therapies including electrocautery, liposuction-assisted curettage, and surgical excision can be done as a last option. Fractional photothermolysis is a recently introduced technology in the field of ablative lasers. Fractional lasers produce microscopic treatment zones (MTZ). The depth and width of MTZ increases with using higher energy levels. The percentage of area covered by fractional lasers is also variable, but leaving microscopic untreated areas will speed healing and reduce down time and risk of complications. The use of fractional lasers in the treatment of Fox– Fordyce disease has not been described before, and to the best of our knowledge, this is the first case report using fractional CO2 laser treatment of this difficult-to-treat condition. In conclusion, we think that fractional CO2 laser may be a treatment option for Fox–Fordyce disease based on the results we have seen in our patient, especially for patients that have tried conventional treatments without good response. Of course this has to be substantiated by further studies including a larger number of patients.

Multipl akrokordonlarla tanı alan tuberoskleroz olgusu

Tuberosclerosis (TS) is an autosomal dominant neuroscutaneous disease characterized with the triad of mental retardation, epilepsy and adenoma sebaceum. The most common affected organs are skin, brain, heart, eyes and kidneys whereas all organs can be involved. A 40-year-old male patient admitted to our clinic with a complaint of acrochordons in his neck and diagnosed with tuberossclerosis. The dermatologic signs of this rare disease are presented and discussed with recent literature. J Clin Exp Invest 2013; 4 (1): 130-133Tuberosclerosis (TS) is an autosomal dominant neurocutaneous disease characterized with the triad of mental retardation, epilepsy and adenoma sebaceum. The most common affected organs are skin, brain, heart, eyes and kidneys whereas all organs can be involved. A 40-yearold male patient admitted to our clinic with a complaint of acrochordons in his neck and diagnosed with tuberosclerosis. The dermatologic signs of this rare disease are presented and discussed with recent literature. J Clin Exp Invest 2013; 4 (1): 130-133