Raihan Hussain

Targeted Alpha Therapy Trial in Bangladesh: Promise for Advanced MUC1 – Expressing Tumors

Introduction: Targeted alpha therapy (TAT) is a new experimental therapy that targets cancer cells and tumor capillary endothelial cells through intravenous injection of an alpha immuneconjugate (AIC). The AIC is formed by labeling the cancer targeting vector (monoclonal antibody) with alpha emitting radioisotopes using a bifunctionalchelator. The monoclonal antibody (MAb) is raised against antigens (e.g. MUC1) over-expressed on the surface of certain cancer cells. There are several centers notably in Europe, the US and Australia that are actively involved in TAT clinical trials of different cancers using a variety of techniques, alpha emitters and MAbs. Observations from their cumulative experience suggest that TAT is safe and effectivebut needs further trials for practical acceptance. Especially critical is the issue of maximum tolerance dose (MTD) which needs to be established for maximum target kill. Bangladesh has the infrastructure to conduct aTAT clinical trial and can significantly add to the growing pool of data for advanced treatment of cancers through collaborative involvement in targeted alpha therapy research. Objective: The aim of the article is to present a general overview of targeted alpha therapy and to discuss the feasibility of a TAT clinical trial in Bangladesh in the context of current cancer management situation in the country. Method: Literature review of significant publications was done to obtain an update of the current status of targeted alpha therapy. Relevant issues of TAT are presented for a theoretical basis of the technology. Next, the methodology of a proposed clinical trial is discussed, together with the practicability of its introduction in Bangladesh. Conclusion: Implementation of TAT clinical trial will help to develop an advanced technology and buildup skilled manpowerin Bangladesh.It will optimize the key parameters of targeted alpha therapy, i e stability and specific activity of the alpha-conjugate and establish the maximum tolerance dose for the AIC. If the clinical trial is successful, it can change the prognosis of many end-stage cancers. Patients in Bangladesh with advanced MUCI expressing tumors of the breast, ovary, pancreas and prostate can have some measure of hope with stability of the disease.

Patient Preparation for 18 F FDG PET-CT scan A Short Communication

18-F fluorodeoxyglucose Positron Emission TomographyComputed Tomography (18F FDG PETCT) scan is an emerging modality of imaging in developing country like us although it is an expensive one. This sophisticated imaging is now available for the general people of Bangladesh, for which a good number of patients used to go to the neighboring countries in previous years. We are proud to say that we are going to stop this trend. Most of the general physicians are eager to be acquainted with this procedure. 18 F FDG PETCT scan play an important role mostly in oncology, less commonly in neurology and cardiology and diagnosis of inflammatory diseases. In oncology, this imaging is useful in diagnosis of primary site of cancer, staging, restaging after treatment, radiation therapy planning and to see the prognosis after chemotherapy and radiotherapy (1). Several factors affect the 18 F FDG PET-CT scan. To get good quality image adequate patient preparation is essential. This article is intended to address the challenges to prepare patients for PETCT scan especially in diabetic patients and other conditions and to disseminate this information to all physicians as well as patients in simple language.

APPLICATION OF EASY Z-SCORE IMAGING SYSTEM IN BANGLADESH FOR QUANTIFICATION OF CEREBRAL BLOOD FLOW IN SUSPECTED ALZHEIMER’S DISEASE AS AN ADJUNCT TO CLINICAL ASSESSMENT

P2-420 APPLICATION OF EASY Z-SCORE IMAGING SYSTEM IN BANGLADESH FOR QUANTIFICATION OF CEREBRAL BLOOD FLOW IN SUSPECTED ALZHEIMER’S DISEASE AS AN ADJUNCT TO CLINICAL ASSESSMENT Nasreen Sultana, Azmal Kabir Sarker, Hiroshi Matsuda, Md. Rafiqul Islam, Sadia Sultana, Jasmine Ara Haque, Raihan Hussain, National Institute of Nuclear Medicine and Allied Sciences, Dhaka, Bangladesh; Institute of Nuclear Medicine and Allied Sciences, Mitford, Dhaka, Bangladesh; National Center of Neurology and Psychiatry, Kodaira, Japan; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh; Society of Nuclear Medicine, Bangladesh, Dhaka, Bangladesh. Contact e-mail: aksninmas@gmail.com

Analysis of mechanical and micro-structural properties of trabecular bones with statistical review of osteoporosis among females in Bangladesh

Osteoporosis is one of the most notable causes of bone fracture and approximately 200 million women are affected by osteoporosis worldwide. According to a report of International Osteoporosis Foundation, at least one in five men and one in three women in Bangladesh suffer a bone fracture due to osteoporosis in their remaining lifetime. Limited data is available in the open literature on osteoporosis among women in Bangladesh and more so on the micro-structural analysis of osteoporosis. The present study particularly aims at identifying the trend of osteoporosis of women of in Bangladesh, with special emphasis on the mechanical micro-structural analysis of female bones. A comprehensive statistical analysis has been conducted by collecting data of 250 Bangladeshi females with age ranging from 20 to 80 years. Trabecular bones of Tibia of female have been analysed with computed tomography for micro-structural assessment. To characterize several parameters of trabecular bones, the computed tomography scans have been analysed and parameters like bone volume fraction, fractal dimension etc. have been evaluated. A correlation between structural properties of the bones has been formed by multiple regression analysis. It shows a positive correlation between fractal dimension and bone volume fraction of the specimens.