Raj N. Misra | Researchain

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Featured researches published by Raj N. Misra.

Tetrahedron Letters | 1985

Synthesis of methylene cyclopropane analogs of arachidonic acid. Potential mechanism-based inhibitors of leukotriene biosynthesis

Raj N. Misra

Abstract The synthesis of methylene cyclopropane arachidonic acid analogs 1 and 2 is described.

Journal of Medicinal Chemistry | 2004

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

Raj N. Misra; Hai-Yun Xiao; Kyoung S. Kim; Songfeng Lu; Wen-Ching Han; Stephanie A. Barbosa; John T. Hunt; David B. Rawlins; Weifang Shan; Syed Z. Ahmed; Ligang Qian; Bang-Chi Chen; Rulin Zhao; Mark S. Bednarz; Kristen A. Kellar; Janet G. Mulheron; Roberta Batorsky; Urvashi V. Roongta; Amrita Kamath; Punit Marathe; Sunanda A. Ranadive; John S. Sack; John S. Tokarski; Nikola P. Pavletich; Francis Y. Lee; and Kevin R. Webster; S. David Kimball

Journal of Medicinal Chemistry | 1997

Dual Metalloprotease Inhibitors: Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase

Jeffrey A. Robl; Chongqing Sun; Jay Stevenson; Denis E. Ryono; Ligaya M. Simpkins; Maria P. Cimarusti; Tamara Dejneka; William Allen Slusarchyk; Sam T. Chao; Leslie Stratton; Raj N. Misra; Mark S. Bednarz; Magdi M. Asaad; Hong Son Cheung; Benoni E. Abboa-Offei; Patricia L. Smith; Parker D. Mathers; Maxine Fox; Thomas R. Schaeffer; and Andrea A. Seymour; Nick C. Trippodo

Journal of Medicinal Chemistry | 2002

Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-Ray Crystallographic Analysis, and Biological Activities

Kyoung S. Kim; S. David Kimball; Raj N. Misra; David B. Rawlins; John T. Hunt; Hai-Yun Xiao; Songfeng Lu; Ligang Qian; Wen-Ching Han; Weifang Shan; Toomas Mitt; Zhen-Wei Cai; Michael A. Poss; Hong Zhu; John S. Sack; John S. Tokarski; Chieh Ying Chang; Nikola P. Pavletich; Amrita Kamath; William G. Humphreys; Punit Marathe; O Isia Bursuker; Kristen A. Kellar; Urvashi V. Roongta; Roberta Batorsky; Janet G. Mulheron; David K. Bol; Craig R. Fairchild; and Francis Y. Lee; Kevin R. Webster

Journal of Medicinal Chemistry | 2000

Thio- and Oxoflavopiridols, Cyclin-Dependent Kinase 1-Selective Inhibitors: Synthesis and Biological Effects

Kyoung S. Kim; John S. Sack; John S. Tokarski; Ligang Qian; Sam T. Chao; Leslie Leith; Yolanda F. Kelly; Raj N. Misra; John T. Hunt; S. David Kimball; William G. Humphreys; Barris S. Wautlet; Janet G. Mulheron; Kevin R. Webster

Archive | 1990

7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease

Raj N. Misra; Philip M. Sher; Philip D. Stein; Steven E. Hall; David M. Floyd; Joel C. Barrish

Journal of Medicinal Chemistry | 1998

Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).

Natesan Murugesan; Zhengxiang Gu; Philip D. Stein; Sharon N. Bisaha; Steve Spergel; Ravi Girotra; Ving G. Lee; John Lloyd; Raj N. Misra; Joan B. Schmidt; Arvind Mathur; Leslie Stratton; Yolanda F. Kelly; Eileen Bird; Tom Waldron; Eddie C.-K. Liu; Rongan Zhang; Helen T. Lee; Randy Serafino; Benoni E. Abboa-Offei; Parker D. Mathers; Mary R. Giancarli; Andrea A. Seymour; Maria L. Webb; Suzanne Moreland; Joel C. Barrish; John T. Hunt

Journal of Medicinal Chemistry | 1993

Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists

Raj N. Misra; Baerbel R. Brown; Philip M. Sher; Manorama Patel; Wen-Ching Han; Joel C. Barrish; Kocy O; Don N. Harris; Goldenberg Hj

Journal of Medicinal Chemistry | 1999

Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KATP) Openers. 6. Effect of Modifications at C6 of Benzopyranyl Cyanoguanidines

Charles Z. Ding; George C. Rovnyak; Raj N. Misra; Gary J. Grover; Arthur V. Miller; Syed Z. Ahmed; Yolanda F. Kelly; Diane E. Normandin; Paul G. Sleph; Karnail S. Atwal

Journal of Medicinal Chemistry | 1991