Rajnish Jain

Salivary vitamins E and C in oral cancer.

Abstract Lipid peroxidation may be involved in cancer and essential nutrients that can scavenge free radicals, such as vitamins E and C, operate in concert. Levels of antioxidant vitamins E and C were estimated in 50 patients with oral cancer and 24 healthy persons served as control. Significantly lower levels of vitamins E and C were observed in oral cancer patients as compared to controls (P < 0.011). Antioxidant nutrients may be utilized to a greater extent in oral cancer patients to counteract free radical-mediated cell disturbances, resulting in a reduction in salivary antioxidant levels.

Salivary and Serum 8-Hydroxydeoxyguanosine Level in Simulated Microgravity

Salivary and Serum 8-Hydroxydeoxyguanosine Level in Simulated Microgravity Background. Microgravity is associated with an increased of peroxidative. The effect is more pronounced after long duration space flight and can even last for several weeks after landing. Aim. To determine the influence of a simulated microgravity on antioxidant status of the human body. Material and Methods. 10 healthy volunteers were studied in condition before, during, and just after the simulated microgravity of -6 head -down -tilt (HDT) bed rest for 10 days. We measured the salivary and serum 8-hydroxydeoxyguanosine before, during and recovery of HDT. Results. The 8-hydroxydeoxyguanosine showed significant increase in simulating microgravity. Conclusion. The data provides evidence that oxidative stress is among critical nutritional concerns for long duration space travellers.

Comparative anti-microbial activity of 15% EDTA and 15% dimercaptosuccinic acid (DMSA)

Dimercaptosuccinic acid (DMSA) chelating agent is used to remove the smear layer more effectively than EDTA. This study was conducted to determine the antimicrobial activity of DMSA and was compared with EDTA. DMSA did not show any antimicrobial activity.

Evaluation of antimicrobial and demineralization inhibitory effects of fluoritop-SR® and bifluorid-12® - An invitro study

This study was conducted to compare the caries preventive efficacy of Fluoritop-SR® , the first fluoride varnish manufactured in India, with Bifluorid-12® . The demineralization inhibitory and antimicrobial effects were studied. In the present study, the demineralization inhibitory effect of the bifluorid-12® (available throughout the world) was higher and comparable to the Fluoritop-SR®.