Rathod Aravind Kumar

Efficient Organocatalytic Synthesis of 1,8-Dioxo-octahydroxanthenes

Abstract L-Proline has been used as an organocatalyst for an efficient synthesis of 1,8-dioxo-octahydroxanthenes by treatment of aldehydes (aromatic, heteroaromatic, and aliphatic) with 5,5-dimethyl-1,3-cyclohexanedione. Three new compounds have been prepared. GRAPHICAL ABSTRACT

Isolation and synthesis of a new chromenochalcone and a new chromene from Orthosiphon glabratus

Chemical investigation on Orthosiphon glabratus afforded 10 compounds, among which a chromenochalcone and a chromene are new. The structures of the new constituents were settled from their 1D- and 2D-NMR spectra. The synthesis of these two compounds and some of their analogues have been accomplished.

PMA/SiO2: An Efficient and Reusable Heterogeneous Catalyst for the Synthesis of β-Acetamidocarbonyl Compounds by Multicomponent Reaction

Abstract Phosphomolybdic acid supported on silica (PMA/SiO2) has been used as an efficient heterogeneous catalyst for the preparation of β-acetamidoketones and esters in good yields. The reaction conditions are mild, and the catalyst can be recycled.

2,3-Dihydrofurans as Potential Cytotoxic and Antibacterial Agents: Tandem Knoevenagel−Michael Cyclization for the Synthesis of 2,3-Dihydrofurans by Using α-Tosyloxy Ketone Precursors

Novel 2,3‐dihydrofuran derivatives were synthesized through a tandem Knoevenagel−Michael cyclization in good yield by reacting α‐tosyloxy ketone, 5,5‐dimethyl‐1,3‐cyclohexanedione, and various aldehydes in the presence of phthalazine in acetonitrile. These compounds were subjected to in vitro antibacterial screening against eight micro‐organisms by using diffusion method and also in vitro cytotoxicity screening against four human cancerous cell lines by applying MTT assay. Some of the compounds showed impressive activities.