Raymond A. Ulan

Fibrous hyperplasia of the gingiva: A side effect of cyclosporin A therapy

Abstract The clinical and histopathologic findings in six patients with gingival fibrous hyperplasia associated with cyclosporin A (CyA) therapy are described. The clinical and histopathologic findings are considered to be indistinguishable from the gingival hyperplasias induced by the anticonvulsant drug, phenytoin (diphenylhydantoin).

Xanthine Nephropathy in a Patient with Lymphosarcoma Treated with Allopurinol

ALLOPURINOL is an agent of proved value for the treatment of hyperuricemic and hyperuricosuric states.1 , 2 Both allopurinol and its principal metabolic product, oxypurinol, inhibit the enzyme xant...

Anti-Donor Immune Responses in Prediction of Transplant Rejection

We assessed various immune responses against donor tissue to determine their value in the diagnosis and prediction of clinical rejection episodes. Twenty-six consecutive clinical renal-transplant recipients were examined. Cell-mediated lymphocytotoxicity preceded and accompanied 41 of 45 rejection episodes (P less than 0.001). Complement-dependent antibody was present in 12 of 15 rejections (P less than 0.002)--four not accompanied by, and eight in association with, cell-mediated lymphocytotoxicity. Mixed lymphocyte reactivity or nonreactivity and inhibition by autologous serum occurred equally often in rejection and quiescence. Lymphocyte-dependent antibody occurred during both rejection episodes and quiescent phases, with a greater frequency during quiescence (P = 0.05). Cell-mediated lymphocytotoxicity was the best predictor of rejection (P less than 0.05). Cell-mediated lymphocytotoxicity was the best predictor of rejection (P less than 0.001), and was more easily suppressed by standard immunosuppressive therapy, than complement-dependent antibody. If specific cell-mediated lymphocytotoxicity, with or without antibody, recurred after rejection therapy, the graft underwent further rejection.

Oxalic acid excretion after methoxyflurane and halothane anaesthesia

SummaryOxalic acid excretion was measured in nine patients receiving methoxyflurane and six patients receiving halothane. Oxalic acid excretion increased from 5 to 23 times in the immediate postoperative period in patients receiving methoxyflurane, whereas no increase was noted in those receiving halothane. Despite the striking increase in oxalic acid excretion, no alteration in renal function and no polyuric state developed. The renal failure that occasionally develops after methoxyflurane anaesthesia appears to be multifactorial in origin and a hyperoxaluric state may play a role in some instances.RésuméOn a mesuré l’excrétion d’acide oxalique chez neuf malades anesthésiés au méthoxyflurane et six malades anesthésiés au fluothane. L’excrétion d’acide oxalique a autmenté de 5 à 23 fois durant la période post-opératoire chez les malades anesthésiés au méthoxyflurane alors que chez les autres on n’a noté aucune augmentation. Malgré cette augmentation frappante de l’excrétion d’acide oxalique, il ne se produisit pas de changement dans la fonction rénale ni de polyurie. Bien que l’insuffissance rénale qui se produit quelquefois après l’anesthésie au méthoxyflurane semple être dûe à plusieurs facteurs, il semble évident que la dose d’anesthésique administrée peut être un facteur crucial.