Is this you? Create Your Porfile
Avatar

Regan G. Shea

Genentech

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Regan G. Shea is active.

Explore More

Publication

Featured researches published by Regan G. Shea.

Nucleosides, Nucleotides & Nucleic Acids | 1995

Structure-Activity Study of Oligodeoxynucleotides Which Inhibit Thrombin

Steven H. Krawczyk; Norbert Bischofberger; Linda C. Griffin; Veronica S. Law; Regan G. Shea; S. Swaminathan

Abstract The 15-mer oligodeoxynucleotide GGTTGGTGTGGTTGG is a potent inhibitor of thrombin and it forms a stable, highly compact structure in solution. Deletions and substitutions by abasic residues, 2′-deoxyinosine, 7-deaza-2′-deoxyguanosine and 8-methyl-2′-deoxyguanosine show that the structural features of the oligodeoxynucleotide are important for its biological activity.

Nucleic Acids Research | 1990

Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates

Regan G. Shea; James C. Marsters; Norbert Bischofberger

Archive | 1990

Covalent conjugates of lipid and oligonucleotide

Norbert Bischofberger; Regan G. Shea

Journal of Medicinal Chemistry | 1998

N2- and C8-substituted oligodeoxynucleotides with enhanced thrombin inhibitory activity in vitro and in vivo

Gong-Xin He; Steven H. Krawczyk; S. Swaminathan; Regan G. Shea; Joseph P. Dougherty; Terry Terhorst; Veronica S. Law; Linda C. Griffin; Steven Coutre; Norbert Bischofberger

Nucleic Acids Research | 1990

Thermal denaturation profiles and gel mobility shift analysis of oligodeoxynucleotide triplexes

Regan G. Shea; Peter Ng; Norbert Bischofberger

Journal of Medicinal Chemistry | 1998

In vitro and in vivo activities of oligodeoxynucleotide-based thrombin inhibitors containing neutral formacetal linkages.

Gong-Xin He; John P. Williams; Michael J. Postich; S. Swaminathan; Regan G. Shea; Terry Terhorst; Veronica S. Law; Cheri T. Mao; Cathy Sueoka; Steven Coutre; Norbert Bischofberger

Archive | 1998

5',5'-linked oligomers having anti-thrombin activity

Norbert Bischofberger; Chris A. Buhr; Joseph P. Dougherty; Brian C. Froehler; Arnold J. Gutierrez; Gong-Xin He; Regan G. Shea; Sundaramoorthi Swaminathan; Matthew A. Williams

Archive | 1990

Conjugue covalent de lipides et d'oligonucleotides.

Norbert Bischofberger; Regan G. Shea

Archive | 1990

Kovalente konjugate von lipiden und oligonukleotiden. Covalent conjugates of lipids and oligonucleotides.

Norbert Bischofberger; Regan G. Shea

Archive | 1990

Conjugados covalentes de lipidos y oligonucleotidos.

Norbert Bischofberger; Regan G. Shea

Explore More

Collaboration

Dive into the Regan G. Shea's collaboration.

Top Co-Authors
Avatar

Norbert Bischofberger

Genentech

View shared research outputs
Top Co-Authors
Avatar

Veronica S. Law

Stanford University

View shared research outputs
Top Co-Authors
Avatar

Linda C. Griffin

Stanford University

View shared research outputs
Top Co-Authors
Avatar

Steven Coutre

Stanford University

View shared research outputs
Top Co-Authors
Avatar

Steven H. Krawczyk

University of Michigan

View shared research outputs
Top Co-Authors
Avatar

Arnold J. Gutierrez

Isis Pharmaceuticals

View shared research outputs
Top Co-Authors
Avatar

Brian C. Froehler

Genentech

View shared research outputs
Top Co-Authors
Avatar

Chris A. Buhr

Exelixis

View shared research outputs
Top Co-Authors
Avatar

James C. Marsters

Genentech

View shared research outputs
Top Co-Authors
Avatar

John P. Williams

Neurocrine Biosciences

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge