Ren-Shen Liu
National Yang-Ming University
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Featured researches published by Ren-Shen Liu.
Applied Radiation and Isotopes | 2013
Chun-Kai Fang; Hong-Wen Chen; Wei-Hsun Wang; Ren-Shen Liu; Jeng-Jong Hwang
In this work, we used quantitative autoradiography to study the acute effect of cocaine, methamphetamine, and ketamine on the uptake of [(18)F]FDOPA in the striatum of rats. Drugs were treated 0.5 h before (pre-treated), and 1.5 h after (post-treated) [(18)F]FDOPA injections, rats were then sacrificed at 2 h post [(18)F]FDOPA injections to determine the striatum/frontal cortex binding ratios in the striatum. The ratios were lower in the post-treated groups than those of the pre-treated groups, suggesting a net effect of inhibition of trapping of the tracer. The order of uptake inhibition is: ketamine>methamphetamine>cocaine.
Nuclear Medicine and Biology | 2012
Shih-Yen Wu; Jia-Wei Kuo; Tien-Kuei Chang; Ren-Shen Liu; Rheun-Chuan Lee; Shyh-Jen Wang; Wuu-Jyh Lin; Hsin-Ell Wang
INTRODUCTION (99m)Tc-labeled macroaggregated albumin ((99m)Tc-MAA) scintigraphy scan is routinely performed for lung perfusion imaging and for the assessment of in vivo distribution of (90)Y-labeled SIR-Spheres prior to selective internal radiation treatment for hepatocellular carcinoma. Positron emission tomography (PET) imaging is superior to gamma scintigraphy in terms of sensitivity, spatial resolution and accuracy of quantification. This study reported that (18)F-labeled macroaggregated albumin ((18)F-MAA) is an ideal PET imaging surrogate for (99m)Tc-MAA. METHODS (18)F-MAA was prepared from the commercial MAA kit via a one-step conjugation with N-succinimidyl 4-(18)F-fluorobenzoate ((18)F-SFB). The biodistribution study and microPET/microSPECT imaging were conducted in normal SD rats after intravenous injection of (18)F-MAA/(99m)Tc-MAA. A comparison study of these two radiotracers was performed after co-injection via the intrahepatic arterial in a N1S1 hepatoma-bearing SD rat model. RESULTS The optimal condition for (18)F-MAA preparation is coupling MAA (0.5mg) with (18)F-SFB at 45°C for 5 min in a phosphate buffer of pH 8.5. (18)F-MAA was prepared in 60 min with high radiochemical yield (30%-35%) and high radiochemical purity (>95%). The in vivo distribution of (18)F-MAA after intravenous injection meets the specifications of MAA depicted in European Pharmacopeia. Our study demonstrated excellent correlation between (18)F-MAA and (99m)Tc-MAA in the regional distribution of tumor, liver and lungs (R(2)=0.965, 0.886 and 0.991, respectively), and also in the tumor-to-liver and tumor-to-lungs ratio (R(2)=0.965 and 0.987, respectively) in a N1S1 hepatoma-bearing SD rat model. The organ uptakes derived from animal PET/CT and SPECT/CT imaging after administration of these two tracers were in accordance with those obtained in the distribution studies. CONCLUSIONS Starting from commercial MAA kit, an efficient preparation of (18)F-MAA was successfully established. Highly correlated, almost parallel, regional distribution of (18)F-MAA and (99m)Tc-MAA in both normal rats and hepatoma-bearing rats was observed. The findings, taken together, demonstrate that (18)F-MAA is an ideal surrogate for (99m)Tc-MAA for clinical PET applications.
Nuclear Medicine and Biology | 2005
Hsin-Ell Wang; Shih-Yen Wu; Chi-Wei Chang; Ren-Shen Liu; Li-Chung Hwang; Te-Wei Lee; Jyh-Cheng Chen; Jeng-Jong Hwang
Applied Radiation and Isotopes | 2007
Chih-Hsien Chang; Ta-Kai Chou; Ren-Shen Liu; Sun-Sang Wang; W.J. Lin; Chuan-Lin Chen; Huann-Sheng Wang
Nuclear Medicine and Biology | 2004
Xin-Xian Ye; Jyh-Cheng Chen; Ren-Shen Liu; Shiaw-Pyng Wey; Jin-Shin Lee; Chia-Chieh Chen; Ying-Kai Fu; Gann Ting; Jeng-Jong Hwang
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment | 2007
Ya-Fang Chang; Yi-Yu Lin; Hsin-Ell Wang; Ren-Shen Liu; Fei Pang; Jeng-Jong Hwang
Applied Radiation and Isotopes | 2004
Jin-Cai Chen; Shin-Ching Chang; F.Y. Hsu; Hsin-Ell Wang; Ren-Shen Liu
Applied Radiation and Isotopes | 2007
Chih-Hsien Chang; Ming-Chia Lin; Shih-Yen Wu; C.H. Hsieh; Ren-Shen Liu; Sun-Sang Wang; K.L. Huang; Chuan-Lin Chen; Hsin-Ell Wang
Applied Radiation and Isotopes | 2009
Chih-Hsien Chang; Yi-Yu Lin; Chi-Jiun Peng; Ming-Chia Lin; Ren-Shen Liu; Sun-Sang Wang; W.J. Lin; Huann-Sheng Wang
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment | 2006
Hung-Man Yu; Hsin-Pei Yeh; Tien-Kui Chang; Kuang-Liang Huang; Kuo-Tang Chuang; Ren-Shen Liu; Shyh-Jen Wang; Jeng-Jong Hwang; Kwan-Hwa Chi; Fu-Du Chen; Wuu-Jyh Lin; Chin-Hsiung Chen; Hsin-Ell Wang