Renata Ortiz Pedrini
Universidade Federal do Rio Grande do Sul
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Publication
Featured researches published by Renata Ortiz Pedrini.
Clinica Chimica Acta | 2008
Eduardo Guimarães Camargo; Renata Ortiz Pedrini; Jorge Luiz Gross; Joiza Lins Camargo; Sandra Pinho Silveiro
Remarkable clinical trials, like the Diabetes Control and Complications Trial (DCCT) and United Kingdom Prospective Diabetes Study (UKPDS), have established that HbA1c is the cornerstone to predict the development of chronic vascular complications in diabetic subjects [1,2]. The American Diabetes Association (ADA) recommends HbA1c measurements at least twice a year, with target levels b7% [3]. However, it should be taken into account that many factors can influence the results, such as the analytical interference of some drugs, like aspirin (acetylsalicylic acid) [4–6]. This is an important issue, because low-dose aspirin is recommended for both primary and secondary cardiovascular disease prevention in diabetic patients [3]. Some in vitro and in vivo studies have suggested a potential interference of aspirin in HbA1c assays, especially in those that rely on the change of charge, like ion-exchange HPLC and electrophoresis [6–8]. Aspirin induces an acetylation of hemoglobin, giving it a negative charge and consequently increasing HbA1c levels in chromatographic assays [9]. There are no randomized clinical trials analyzing the possible effects of the antiplatelet agent on HbA1c values measured by ionexchange HPLC assay in diabetic patients. Therefore, the aim of this study was to evaluate the influence of low-dose aspirin on HbA1c levels measured by this method in type 2 diabetic patients. In this randomized, crossover, double-blind, placebocontrolled study, 14 type 2 DM patients received aspirin (300 mg/d) or an identical placebo for 8 weeks, with a 6week washout period. All patients signed a written informed consent approved by the Ethics Committee of the Hospital. The sample size calculation disclosed that a minimum of 12 patients was needed to detect an absolute change in HbA1c N0.5% (α=0.05 and β=0.20). The patients entered a run-in phase of 8 weeks, to stabilize metabolic control. All patients, except for 2 who received only insulin, used metformin, either alone or in combination
Clinical & Biomedical Research | 2008
Rafael Bueno Orcy; Renata Ortiz Pedrini; Pedro Salomão Piccinini; Sabrina Schroeder; Sérgio Hofmeister Martins-Costa; José Geraldo Lopes Ramos; Edison Capp; Helena von Eye Corleta
Rev. HCPA & Fac. Med. Univ. Fed. Rio Gd. do Sul | 2007
Rafael Bueno Orcy; Renata Ortiz Pedrini; Pedro Salomão Piccinini; Sabrina Schroeder; Sergio Hofmeister de Almeida Martins Costa; José Geraldo Lopes Ramos; Edison Capp; Helena von Eye Corleta
Archive | 2008
Bittencourt Detanico; Renata Ortiz Pedrini; Letícia Schwerz Weinert; Eduardo Guimarães; Jorge Luiz Gross
Archive | 2008
Renata Ortiz Pedrini; Ana Bittencourt Detanico; Letícia Schwerz Weinert; Eduardo Guimarães Camargo; Jorge Luiz Gross
Clinical & Biomedical Research | 2008
Eduardo Guimarães Camargo; Ana Bittencourt Detanico; Renata Ortiz Pedrini; Sandra Pinho Silveiro
Archive | 2007
Ana Bittencourt Detanico; Renata Ortiz Pedrini; Letícia Schwerz Weinert; Eduardo Guimarães Camargo; Jorge Luiz Gross
Archive | 2007
Renata Ortiz Pedrini; Letícia Schwerz Weinert; Eduardo Guimarães Camargo; Jorge Luiz Gross
Archive | 2007
Eduardo Guimarães Camargo; Ana Bittencourt Detanico; Renata Ortiz Pedrini; Sandra Pinho Silveiro
Archive | 2006
Renata Ortiz Pedrini; Pedro Salomão Piccinini; Rafael Bueno Orcy; Sabrina Schroeder; Sergio Hofmeister de Almeida Martins Costa; José Geraldo Lopes Ramos; Harald H. Klein; Wolfgang Schechinger; Helena von Eye Corleta
Collaboration
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Sergio Hofmeister de Almeida Martins Costa
Universidade Federal do Rio Grande do Sul
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