Reza Mostofi

Low-grade papillary adenocarcinoma of minor salivary glands

Low-grade papillary adenocarcinoma of minor salivary glands is rare and tends to occur in the palate. This tumor has distinct but rather deceptive histomorphologic features, which may cause erroneous diagnosis. An extensive English-language literature review revealed reports of 22 well-documented low-grade papillary adenocarcinomas. Six of these tumors (27%) recurred locally between 12 months and 19 years after initial treatment. Low-grade papillary adenocarcinoma appears to have more aggressive biologic behavior compared with other low-grade adenocarcinomas in this region. Four of the reported cases (17%) had cervical lymph node metastases at the time of presentation. We report an additional case and discuss the literature.

Oral malignant acanthosis nigricans

Awareness of a possible association of late-onset oral acanthosis nigricans with internal malignant disorders is important for early detection and treatment of the underlying cancer. A classic case of malignant oral acanthosis nigricans is reported here, and its possible etiologic factors and pathogenetic mechanisms are discussed.

Steatocystoma simplex in the oral cavity: a previously undescribed condition.

A rare lesion, steatocystoma simplex, in a previously unreported location, the oral cavity, is described. A case report, the differential diagnosis, and a review of the literature are offered. Differentiation between this cyst and steatocystoma multiplex is important in terms of the need for clinical follow-up.

Intraoral periosteal nodular fasciitis

Intraoral periosteal nodular fasciitis is an extremely rare tumor with only 2 cases having been previously recorded in the literature. We report here the 3rd case and review the characteristic features, the differential diagnosis and the treatment of intraoral periosteal nodular fasciitis.

Intraoral benign mesenchymoma

Benign mesenchymoma is a tumor composed of two or more benign mesenchymal elements in addition to fibrous connective tissue. A case of benign mesenchymoma of the lip in a 38-year-old man is presented, and the literature is reviewed.

Pancreatic carcinoma metastatic to the mandibular gingiva

Abstract A case of metastatic pancreatic adenocarcinoma to the gingiva of a 46-year-old black man is presented. The literature of these rare lesions is reviewed.

Alterations in glycoconjugate expression following malignant transformation of human oropharyngeal squamous mucosa

Malignant transformation of the squamous mucosa in the human oropharynx may be accompanied by alterations in carbohydrate production. Glycoconjugate expression was assessed by examining lectin‐binding patterns and ABH isoantigen expression in human biopsy specimens from nine cases of carcinoma in situ and ten cases of invasive squamous cell carcinoma as well as adjacent normal squamous mucosa. Ten different fluoresceinconjugated lectins were used. Each lectin binds to specific nonreducing end‐terminal carbohydrate residues. Wheat germ agglutinin and peanut agglutinin displayed intense cytoplasmic and/or membrane binding in more than 90% of the carcinoma in situ and squamous cell carcinoma specimens. However, only 40% of normal squamous epithelium specimens displayed intense cytoplasmic and/or membrane binding with wheat germ agglutinin and peanut agglutinin. Bandieraea simplicifolia I and Helix pomatia exhibited weak binding in less than 35% of normal and neoplastic tissues. Weak cnnnvalia ensiformis binding was identified infrequently in the superficial layers of normal squamous mucosa, but was not found in neoplastic epithelium. None of the cases displayed binding for Dolichos biflorus, Ulex europaeus I, Sophora japonica, Glycine maximus, or Ricinus communis. Monoclonal antibodies directed against ABH blood group isoantigens showed increased cytoplasmic immunoreactivity for anti‐H in dysplastic and neoplastic tissues, when compared with normal squamous mucosa. These findings indicate that wheat germ agglutinin and peanut agglutinin and H isoantigen are useful markers of malignancy in squamoproliferative lesions of the oropharynx, apparently reflecting alterations in expression of N‐acetyl‐D‐glucosamine and galactose‐related sugars, which appear following malignant transformation.

Palatal mass of 10 years' duration

It is important to be able to distinguish the polymorphous low-grade adenocarcinoma from other adenocarcinomas of the salivary gland. Histological interpretation of this lesion appears to be the only approach for a proper diagnosis