Ricardo Labes

Integrated plug flow synthesis and crystallisation of pyrazinamide

We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.

Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

A continuous flow method for the selective reduction of aromatic nitriles to the corresponding amine is reported. The method is based on a ruthenium-catalysed transfer-hydrogenation process, requires no additives, and uses isopropanol as both solvent and reducing agent. The process utilizes 1 mol% of the commercially available [Ru( p -cymene)Cl 2 ] 2 , with a residence time of ca. 9 min, and a throughput of 50 mmol/h. The method was successfully applied to a range of aromatic nitriles providing the corresponding primary amines in good yields.

ESI from Rapid Continuous Ru-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

Supplementary information for the working paper Rapid Continuous Ru-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

ESI from Chemoselective Continuous Ru-Catalyzed Hydrogen-transfer Oxidation of Secondary Alcohols

Supplementary information data for working article entitled: Chemoselective Continuous Ru-Catalyzed Hydrogen-transfer Oxidation of Secondary Alcohol.