Ricardo Luiz Cavalcanti De Albuquerque-Júnior
Universidade Federal de Sergipe
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Featured researches published by Ricardo Luiz Cavalcanti De Albuquerque-Júnior.
Journal of Ethnopharmacology | 2012
K.R. Riella; Renata R. Marinho; Jandson de Souza Santos; R.N. Pereira-Filho; Juliana Cordeiro Cardoso; Ricardo Luiz Cavalcanti De Albuquerque-Júnior; Sara Maria Thomazzi
ETHNOPHARMACOLOGICAL RELEVANCE Lippia gracilis Schauer (Verbenaceae) has long been recognized in folk medicine as a medicinal plant. The essential oil of Lippia gracilis has antimicrobial activity and is used externally to treat cutaneous diseases, burns, wounds, and ulcers. Recently, our research group demonstrated that the essential oil of Lippia gracilis leaves possesses antinociceptive and anti-inflammatory actions and its major component identified was thymol. The objective of this study was to assess the anti-inflammatory and wound healing activities of thymol in rodents. MATERIALS AND METHODS For the anti-inflammatory analysis the paw oedema and peritonitis models were used, followed by the assessment of the mieloperoxidase (MPO) activity, total cell counting, and histological analysis. The animals were treated (i.p., n=6/group) with thymol (10, 30, and 100 mg/kg), dexamethasone (2 mg/kg), or vehicle (1% Tween 80). In order to assess the wound healing potential, thymol was vehiculated into collagen-based dressing films and a biological wound healing test was conducted. The retraction index of the wounds and histological analysis were performed on the 3rd, 7th, 14th, and 21th days, split into three groups: undressed wounds (CTR), dressed with collagen-based films (COL), and dressed with collagen-based containing thymol (COLTHY) films. RESULTS Thymol reduced significantly the oedema (100 mg/kg, P<0.001) and, besides, diminished the influx of leukocytes to the injured area (10, 30, and 100 mg/kg), according to the assessment of MPO activity (P<0.001), total cell count (P<0.05), and histological analysis. Wounds dressed with COLTHY films showed significantly bigger wound retraction rates (7 and 14 day, P<0.05) and improved the granulation reaction, as well provided better collagenization density and arrangement during wound healing. CONCLUSIONS This study suggests that thymol is a promising compound to be used in treatment of inflammatory processes as well as wound healing. The pharmacological actions of Lippia gracilis in popular medicine practices may be related, at least in part, to the presence of thymol in the essential oil.
BioMed Research International | 2011
Paula Santos Nunes; Ricardo Luiz Cavalcanti De Albuquerque-Júnior; Danielle R. R. Cavalcante; Marx D. M. Dantas; Juliana Cordeiro Cardoso; Marília dos Santos Bezerra; Jamille Cristina Campos de Souza; Mairim Russo Serafini; Lucindo J. Quitans-Jr; Leonardo Rigoldi Bonjardim; Adriano Antunes de Souza Araújo
The aim of this study was assess the effect of collagen-based films containing usnic acid as a wound dressing for dermal burn healing. Second-degree burn wounds were performed in forty-five Wistar rats, assigned into nine groups: COL—animals treated with collagen-based films; PHO—animals treated with collagen films containing empty liposomes; UAL—animals treated with collagen-based films containing usnic acid incorporated into liposomes. After 7, 14, and 21 days the animals were euthanized. On 7th day there was a moderate infiltration of neutrophils, in UAL, distributed throughout the burn wounds, whereas in COL and PHO, the severity of the reaction was slighter and still limited to the margins of the burn wounds. On the 14th day, the inflammatory reaction was less intense in UAL, with remarkable plasma cells infiltration. On the 21st day, there was reduction of the inflammation, which was predominantly composed of plasma cells in all groups, particularly in UAL. The use of the usnic acid provided more rapid substitution of type-III for type-I collagen on the 14th day, and improved the collagenization density on the 21st day. It was concluded that the use of reconstituted bovine type-I collagen-based films containing usnic acid improved burn healing process in rats.
Journal of Ethnopharmacology | 2013
Enrik Barbosa de Almeida; Juliana Cordeiro Cardoso; Adriana Karla Lima; Nívia Lucas de Oliveira; Nicodemos Teles de Pontes-Filho; Sônia Oliveira Lima; Isana Carla Leal Souza; Ricardo Luiz Cavalcanti De Albuquerque-Júnior
ETHNOPHARMACOLOGICAL RELEVANCE Hydroalcoholic solutions of propolis, a resinous product produced by bees, have been currently employed in improving the cicatricial repair. Biological activity of propolis might be related to its antimicrobial, anti-inflammatory and immunomudalatory properties. AIM OF THIS STUDY Investigate the suitability of the collagen-based films containing hydroalcoholic extracts of two different varieties of Brazilian propolis (green and red ones) on the dermal burn healing in rodent model. MATERIALS AND METHODS The hydroalcoholic extracts of red propolis (RP) or Green propolis (GP) were incorporated into collagen-based dressing films (COL). Burn wounds were performed in the dorsum of Wistar rats and dressing with COL, COL+GPa (0.5%), COL+GPb (1,0%) or COL+RP (0.5%). A control group (CTR) was performed keeping the wound undressed. The histological analyses were carried out after 3, 7, 14, 21 and 30 days for histological assessment of the inflammatory response, epithelization rates (ER), myofibroblastic count (MC) and collagenization pattern. RESULTS GPa, GPb and RP provided significant decrease of the inflammatory severity, improved the ER in GPa in 7 (p=0.000), 14 (p=0.000), 21 (p=0.005) and 30 days (p=0.015), and induced earlier replacement of type-III for type-I collagen (p<0.05) than COL and CTR. In all the groups, the MC increased progressively from 3 to 14 days, and then started to decrease slowly until 21 days. Although no significant difference was observed among the groups in 3, 7 and 30 days, the MC was significantly increased in RP in 14 (p=0.0001) and 21 days (p=0.04), as well as grosser interlacement of the collagen bundles compared with the other groups. CONCLUSION The incorporation of hydroalcoholic extracts of Brazilian propolis improved the biological events associated to burn healing without toxic effects, but the red variety provided the best results. Therefore, these collagen-based containing natural apicultural products films may be considered a promising new dressing for wound occlusion and tissue repairing.
International Journal of Morphology | 2009
Ricardo Luiz Cavalcanti De Albuquerque-Júnior; André Luiz Santos Barreto; Jônatas Almeida Pires; Francisco Prado Reis; Sônia Oliveira Lima; Maria Amália Gonzaga Ribeiro; Juliana Cordeiro Cardoso
El propoleo es un producto apiterapico ampliamente usado en medicina natural, que presenta diversas propiedades biologicas, como actividad bactericida y anti-inflamatoria, pero pocos informes han examinado la variedad brasilena del propoleo rojo. Peliculas de colageno han sido empleadas para mejorar la cicatrizacion de heridas y en algunos estudios se ha investigado el efecto de los productos naturales incorporados en estas peliculas. Asi el objetivo de este estudio fue analizar el efecto de las peliculas a base de colageno que contienen propoleo rojo en la cicatrizacion de heridas. Heridas realizadas en el dorso de ratas fueron revestidas con peliculas a base de colageno (G2) y con peliculas a base de colageno con propoleo rojo (G3), heridas sin revestimiento fueron utilizadas como control (G1). Despues de 3, 7 y 14 dias, las heridas fueron evaluadas microscopicamente. A los 7 dias G3 mostro un cambio del perfil de la respuesta inflamatoria de aguda a cronica, con aumento de la diferenciacion de las celulas plasmaticas, sustitucion de fibras de colageno tipo III por tipo I con mejora de la organizacion arquitectonica de estas fibras. Ademas, una ligera tendencia a una mejor epitelizacion se verifico en G3, pero no fue estadisticamente significativa. Tambien a los 7 dias, el conteo de microvasos fue mayor en G1 que en G2 (p=0,000) y G3 (p=0,001), pero similar entre los ultimos grupos (p=0,15), mientras que el perimetro de los microvasos fue mayor en G1 que en G2 (p=0,000) y G3 (p=0,002), pero equivalente en G2 y G3 (p=0,175) en 14 dias. En conclusion, la incorporacion de la variedad brasilena de propoleo rojo en peliculas a base de colageno fue capaz de mejorar la cicatrizacion de la herida, probablemente por la modulacion de la dinamica de la evolucion inflamatoria y del proceso de deposito de colageno.
International Journal of Molecular Sciences | 2014
Simone S. Nascimento; Adriano Antunes de Souza Araújo; Renan G. Brito; Mairim Russo Serafini; Paula P. Menezes; Josimari Melo DeSantana; Waldecy de Lucca Júnior; Péricles Barreto Alves; Arie Fitzgerald Blank; Rita de Cássia Meneses Oliveira; Aldeídia P. Oliveira; Ricardo Luiz Cavalcanti De Albuquerque-Júnior; Jackson Roberto Guedes da Silva Almeida; Lucindo J. Quintans-Júnior
O. basilicum leaves produce essential oils (LEO) rich in monoterpenes. The short half-life and water insolubility are limitations for LEO medical uses. β-Cyclodextrin (β-CD) has been employed to improve the pharmacological properties of LEO. We assessed the antihyperalgesic profile of LEO, isolated or complexed in β-CD (LEO/β-CD), on an animal model for fibromyalgia. Behavioral tests: mice were treated every day with either LEO/β-CD (25, 50 or 100 mg/kg, p.o.), LEO (25 mg/kg, p.o.), tramadol (TRM 4 mg/kg, i.p.) or vehicle (saline), and 60 min after treatment behavioral parameters were assessed. Therefore, mice were evaluated for mechanical hyperalgesia (von Frey), motor coordination (Rota-rod) and muscle strength (Grip Strength Metter) in a mice fibromyalgia model. After 27 days, we evaluated the central nervous system (CNS) pathways involved in the effect induced by experimental drugs through immunofluorescence protocol to Fos protein. The differential scanning analysis (DSC), thermogravimetry/derivate thermogravimetry (TG/DTG) and infrared absorption spectroscopy (FTIR) curves indicated that the products prepared were able to incorporate the LEO efficiently. Oral treatment with LEO or LEO-βCD, at all doses tested, produced a significant reduction of mechanical hyperalgesia and we were able to significantly increase Fos protein expression. Together, our results provide evidence that LEO, isolated or complexed with β-CD, produces analgesic effects on chronic non-inflammatory pain as fibromyalgia.
Molecules | 2014
Rosana S. S. Barreto; Ricardo Luiz Cavalcanti De Albuquerque-Júnior; Adriano Antunes de Souza Araújo; Jackson Roberto Guedes da Silva Almeida; Márcio R. V. Santos; André Sales Barreto; Josimari Melo DeSantana; Pollyana S. Siqueira-Lima; Jullyana de Souza Siqueira Quintans; Lucindo J. Quintans-Júnior
The search for more effective and lower cost therapeutic approaches for wound healing remains a challenge for modern medicine. In the search for new therapeutic options, plants and their metabolites are a great source of novel biomolecules. Among their constituents, the monoterpenes represent 90% of essential oils, and have a variety of structures with several activities such as antimicrobial, anti-inflammatory, antioxidant and wound healing. Based on that, and also due to the lack of reviews concerning the wound-healing activity of monoterpenes, we performed this systematic review—which provides an overview of their characteristics and mechanisms of action. In this search, the terms “terpenes”, “monoterpenes”, “wound healing” and “wound closure techniques” were used to retrieve articles published in LILACS, PUBMED and EMBASE until May 2013. Seven papers were found concerning the potential wound healing effect of five compouds (three monoterpenes and two iridoid derivatives) in preclinical studies. Among the products used for wound care, the films were the most studied pharmaceutical form. Monoterpenes are a class of compounds of great diversity of biological activities and therapeutic potential. The data reviewed here suggest that monoterpenes, although poorly studied in this context, are promising compounds for the treatment of chronic wound conditions.
Zeitschrift für Naturforschung C | 2010
Rosana S. Siqueira; Leonardo Rigoldi Bonjardim; Adriano Antunes de Souza Araújo; Bruno Eduardo Silva Araujo; Marcelia Garcez Dória de Melo; Marília G. B. Oliveira; Daniel Pens Gelain; Francilene Amaral da Silva; Josimari Melo DeSantana; Ricardo Luiz Cavalcanti De Albuquerque-Júnior; Ricardo Fagundes da Rocha; José Cláudio Fonseca Moreira; Angelo R. Antoniolli; Lucindo J. Quintans-Júnior
Physicochemical characterization and antinociceptive and anti-inflammatory activities of atranorin (AT) extracted from Cladina kalbii Ahti in formalin- and capsaicin-induced orofacial pain and anti-inflammatory tests in rodents were studied. Physicochemical characterization showed that AT has the general formula C19H18O8. Male Swiss mice were pretreated with AT (100, 200, and 400 mg/kg, i.p.), morphine (3 mg/kg, i.p.), or vehicle (0.9% saline with two drops of 0.2% Tween 80) before formalin (20 μl, 2%) or capsaicin (20 μl, 2.5 μg) were injected into the right vibrissa. Our results showed that i.p. treatment with AT displayed marked inhibitory effects in different orofacial pain tests in mice. AT (400 mg/kg, i.p.) was effective in reducing the nociceptive face-rubbing behavioural response in both phases of the formalin test, which was also naloxone-sensitive. Additionally, AT produced a significant antinociceptive effect at all doses in the capsaicin test. Such results were unlikely to be provoked by motor abnormality, since AT-treated mice exhibited no performance alteration on the rota rod apparatus. AT exhibited significant anti-inflammatory activity in the acute model of inflammation (leukocyte migration to the peritoneal cavity), carrageenan- and arachidonic acid-induced hind paw edema in rats. Additionally, AT exhibited a dose-dependent antioxidant activity in vitro, as assessed by total radical-trapping antioxidant parameter and total antioxidant reactivity assays. All these findings suggest that AT might represent an important tool for the management of orofacial pain and/or inflammatory disorders
Chemico-Biological Interactions | 2016
Ana Roseli S. Ribeiro; Polyana B.F. Diniz; Malone S. Pinheiro; Ricardo Luiz Cavalcanti De Albuquerque-Júnior; Sara Maria Thomazzi
Thymol, a monoterpene phenol derivative of cymene, is found in abundance in the essential oils of Thymus, Origanum, and Lippia species. The present study investigated the gastroprotective actions of thymol (10, 30, and 100 mg/kg, p.o.) in the acute (ethanol- and nonsteroidal anti-inflammatory drug-induced ulcers) and chronic (acetic acid-induced ulcers) ulcer models in rats. Some of the mechanisms underlying to the gastroprotective effect of thymol were investigated in the ethanol-induced ulcer model. Gastric secretion parameters (volume, pH, and total acidity) were also evaluated by the pylorus ligature model, and the mucus in the gastric content was determined. The anti-Helicobacter pylori activity of thymol was performed using the agar-well diffusion method. Thymol (10, 30, and 100 mg/kg) produced dose dependent reduction (P < 0.01) on the total lesion area in the ethanol-induced ulcer model. The gastroprotective response caused by thymol (30 mg/kg) was significantly attenuated (P < 0.001) by intraperitoneal treatment of rats with indomethacin (a non-selective inhibitor of cyclo-oxygenase, 10 mg/kg) and glibenclamide (ATP-sensitive K(+) channel blocker, 10 mg/kg), but not by DL-Propargylglycine (PAG, a cystathionine-γ-lyase inhibitor, 25 mg/kg) and Nw-nitro-L-arginine methyl ester hydrochloride (L-NAME, a non-selective inhibitor of nitric oxide synthase, 70 mg/kg). Thymol (30 and 100 mg/kg) also reduced the ulcer index (P < 0.05) and the total lesion area (P < 0.001) in the indomethacin- and acetic-acid-induced ulcer models, respectively. In the model pylorus ligature, the treatment with thymol failed to significantly change the gastric secretion parameters. However, after treatment with thymol (30 and 100 mg/kg), there was a significant increase (P < 0.01) in mucus production. Thymol no showed anti-H. pylori activity in vitro. Collectively, the present results provide convincing evidence that thymol displays gastroprotective actions on the acute and chronic ulcer models through mechanisms that involve increased in the amount of mucus, prostaglandins, and ATP-sensitive K(+) channels.
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy | 2013
Rosana S. S. Barreto; Ricardo Luiz Cavalcanti De Albuquerque-Júnior; Rose Nely Pereira-Filho; Jullyana de Souza Siqueira Quintans; André Sales Barreto; Josimari Melo DeSantana; Valter J. Santana-Filho; Márcio R. V. Santos; Leonardo Rigoldi Bonjardim; Adriano Antunes de Souza Araújo; Lucindo J. Quintans-Júnior
The aim of this study was to investigate the wound healing activity of atranorin cream (Patent requested) on excision wounds. Seventy-two male rats were anesthetized and an excisional wound was performed. Then the rats were randomly assigned into three groups: untreated control group; atranorin 1 (group treated with 1% AT ointment); and atranorin 5 (group treated with 5% AT ointment). Six animals of each group were euthanized 3, 7, 14 or 21 days after surgical procedures and the wounded areas were analyzed and removed. Serial histological sections were obtained and stained by histochemical techniques (Hematoxilin-Eosin-HEand Sirius red) and immunohistochemical techniques. Topical application of atranorin reduced wound areas, induced earlier granulation tissue formation, increased cell proliferation, improved collagenization and modulated the myofibroblasts differentiation when compared to control animals. It is suggested that atranorin modulates the wound healing process. These data suggest that this formulation based on atranorin extracted from Cladina kalbii AHTI may be a new biotechnological product for wound healing clinical applications.
Journal of Photochemistry and Photobiology B-biology | 2016
Vinícius Lima de Almeida; Vanessa Lima de Andrade Gois; Ramon Nazareno Menezes Andrade; Carla Patrícia Hernandez Alves Ribeiro César; Ricardo Luiz Cavalcanti De Albuquerque-Júnior; Sigmar de Mello Rode; Luiz Renato Paranhos
The low level laser is widely used in Dentistry, in particular, to decrease pain and increase the speed of tooth movement. This study was to perform a systematic literature search to investigate the effectiveness of low level laser and low energy density therapy of the induced tooth movement. This research was performed following the PRISMA instructions and was registered in the PROSPERO. The articles were searched in six electronic databases, with no date and language restriction. Only randomized clinical trials were selected. Articles that did not use the extraction of first premolars as orthodontic planning were excluded, as well as articles using high energy density laser therapy. The articles were assessed for risk of bias and individual quality. The results were analyzed using meta-analysis, using randomized effect. The initial sample consisted of 161 articles. Six articles remained eligible for qualitative analysis and five for quantitative analysis. According to the individual quality, most articles were classified as high quality. Three articles detected statistically significant differences in induced movement by comparing the orthodontic movement between the experimental and control groups. For the maxilla, there was a statistically significant influence of the laser in three months and, for the mandible, in one month. It may be concluded that there is no evidence that laser therapy can accelerate the induced tooth movement.
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National Council for Scientific and Technological Development
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Federal University of Rio Grande do Norte
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