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Richard A. Holmes

Medical College of Wisconsin

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Publication

Featured researches published by Richard A. Holmes.

International Journal of Nuclear Medicine and Biology | 1984

Biodistribution of lipophilic 99mTc complexes of Cyclam Derivatives

Alan R. Ketring; David E. Troutner; Timothy J. Hoffman; Danny K. Stanton; Wynn A. Volkert; Richard A. Holmes

Several n-alkyl-cyclam derivatives were synthesized which form stable single component cationic chelates with 99mTc. These results suggest that the cyclam moiety in these derivatives complexes 99mTc in the same manner as the underivatized macrocycle. Biodistribution studies in mice show that all of these chelates are cleared from circulation by both the kidneys and liver. The ratio and rates of clearance by these organ systems is related to lipid solubility. None of the lypophilic-cationic-99mTc agents show any significant myocardial uptake. Also, these chelates show no significant ability to penetrate the blood-brain-barrier.

The Journal of Nuclear Medicine | 1992

Samarium-153-EDTMP: Pharmacokinetic, Toxicity and Pain Response Using an Escalating Dose Schedule in Treatment of Metastatic Bone Cancer

Mehdi Farhanghi; Richard A. Holmes; Wynn A. Volkert; K. William Logan; Amolak Singh

The Journal of Nuclear Medicine | 1989

Human pharmacokinetics of samarium-153 EDTMP in metastatic cancer

Amolak Singh; Richard A. Holmes; Medhi Farhangi; Wynn A. Volkert; Andrew Williams; Lynn M. Stringham; Alan R. Ketring

The International Journal of Applied Radiation and Isotopes | 1984

A neutral lipophilic complex of 99mTc with a multidentate amine oxime.

David E. Troutner; Wynn A. Volkert; Timothy J. Hoffman; Richard A. Holmes

The Journal of Nuclear Medicine | 1975

Enzymatic inhibition of diphosphonate: a proposed mechanism of tissue uptake

A. M. Zimmer; Isitman At; Richard A. Holmes

The Journal of Nuclear Medicine | 1988

Kinetic Analysis of Technetium-99m d, 1-HM-PAO Decomposition in Aqueous Media

Joseph C. Hung; Melvin Corlija; Wynn A. Volkert; Richard A. Holmes

The Journal of Nuclear Medicine | 1980

Complexing of Tc-99m with cyclam: concise communication.

David E. Troutner; Jaime Simon; Alan R. Ketring; Wynn A. Volkert; Richard A. Holmes

The Journal of Nuclear Medicine | 1978

Quantification of Skeletal Tc-99m Labeled Phosphates to Detect Metabolic Bone Disease

Richard A. Holmes

The Journal of Nuclear Medicine | 1983

Technetium-99m glucoheptonate imaging in lung cancer and benign lung diseases: concise communication

Paul M. Passamonte; Richard M. Seger; Richard A. Holmes; Daniel J. Hurst

The Journal of Nuclear Medicine | 1986

A Reawakening of Interest in Radionuclide Brain Imaging

Richard A. Holmes

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Wynn A. Volkert

University of Missouri

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Alan R. Ketring

University of Missouri

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David E. Troutner

University of Missouri

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Amolak Singh

University of Missouri

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Timothy J. Hoffman

University of Missouri

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A. M. Zimmer

Medical College of Wisconsin

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Edward A. Silverstein

Medical College of Wisconsin

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Richard M. Seger

University of Missouri

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Jaime Simon

Dow Chemical Company

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A. Michael Zimmer

Medical College of Wisconsin

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