Richard H. Yu

Practical synthesis of the anti-HIV drug, PMPA

Abstract The anti-HIV nucleotide analogue PMPA can be prepared on a kilogram-scale by a three step sequence: i) condensation of adenine with ( R )-propylene carbonate, ii) alkylation of the resulting ( R )-9-(2-hydroxypropyl)adenine with diethyl p -toluenesulfonyloxymethanephosphonate using lithium tert -butoxide and iii) cleavage of the phosphonate ester functionalities with bromotrimethylsilane.

An Efficient and Convenient Synthesis of Chain Lengthened Homologs of the Fungicide Metalaxyl

Abstract An efficient and convenient synthesis of chain lengthened homologs of the important fungicide Metalaxyl is described. The starting material utilized is 2,6-dimethylaniline and the sequence is accomplished utilizing Grignard reactions and ruthenium based oxidations to obtain the proper analogs.

NEW REACTIONS OF QUATERNARY AMMONIUM SALTS DERIVED FROM VINAMIDINIUM SALT REDUCTION PRODUCTS AND A REASSIGNMENT OF STRUCTURE

Abstract The structure of a vinamidinium salt reduction product is revised and some reactions of related allylic ammonium salts with sulfur nucleophiles is presented.