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Richard Jiao

Merck & Co.

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Publication

Featured researches published by Richard Jiao.

Bioorganic & Medicinal Chemistry Letters | 2009

Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.

Shankaran Kothandaraman; Karla L. Donnely; Gabor Butora; Richard Jiao; Alexander Pasternak; Gregori J. Morriello; Stephen D. Goble; Changyou Zhou; Sander G. Mills; Malcolm Maccoss; Pasquale P. Vicario; Julia M. Ayala; Julie A. DeMartino; Mary Struthers; Margaret A. Cascieri; Lihu Yang

A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found to posses potent antagonistic activity.

Archive | 2003

Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Richard Jiao; Gregori J. Morriello; Lihu Yang; Stephen D. Goble; Sander G. Mills; Alexander Pasternak; Changyou Zhou; Gabor Butora; Shankaran Kothandaraman; Deodialsingh Guiadeen; Christopher Richard Moyes; Cheng Tang

Archive | 2003

Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity

Richard Jiao; Stephen D. Goble; Sander G. Mills; Gregori J. Morriello; Alexander Pasternak; Lihu Yang; Changyou Zhou; Gabor Butora; Shankaran Kothandaraman; Deodialsingh Guiadeen; Christopher Richard Moyes

Journal of Medicinal Chemistry | 2007

Discovery of 3-Piperidinyl-1-cyclopentanecarboxamide as a Novel Scaffold for Highly Potent CC Chemokine Receptor 2 Antagonists

Lihu Yang; Gabor Butora; Richard Jiao; Alex Pasternak; Changyou Zhou; William H. Parsons; Sander G. Mills; Pasquale P. Vicario; Julia M. Ayala; Margaret A. Cascieri; Malcolm Maccoss

Bioorganic & Medicinal Chemistry Letters | 2007

3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2.

Gabor Butora; Richard Jiao; William H. Parsons; Pasquale P. Vicario; Hong Jin; Julia M. Ayala; Margaret A. Cascieri; Lihu Yang

Archive | 2004

Amino cyclobutylamide modulators of chemokine receptor activity

Richard Jiao; Lihu Yang

Archive | 2005

Tetrahydropyranyl cyclopentyl tetrahy-dropyridopyridine modulators of chemokine receptor activity

Lihu Yang; Sander G. Mills; Richard Jiao

Archive | 2009

Tetrahydropyranyl cyclopentyl tetrah- ydropyridopyrdine modulators of chemohne receptor activity.

Richard Jiao; Gregori J. Morriello; Christopher Richard Moyes; Lihu Yang

Archive | 2004

MODULATEURS TETRAHYDROPYRANYLE CYCLOPENTYLE TETRAHYDROPYRIDO PYRIDINE DE L'ACTIVITE D'UN RECEPTEUR DE CHIMIOKINE

Richard Jiao; Christopher Richard Moyes; Lihu Yang; Gregori J. Morriello

Archive | 2003

Tetrahydropyranylcyclopentyltetrahydroisochino-linmodulatoren der chemokinrezeptoraktivität Tetrahydropyranylcyclopentyltetrahydroisochino-linmodulatoren of chemokine receptor activity

Richard Jiao; Stephen D. Goble; Sander G. Mills; Gregori J. Morriello; Alexander Pasternak; Lihu Yang; Changyou Zhou; Gabor Butora; Shankaran Kothandaraman; Deodialsingh Guiadeen; Christopher Richard Moyes

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Collaboration

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Lihu Yang

Merck

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Gabor Butora

Merck

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Gregori J. Morriello

Merck

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Sander G. Mills

Merck

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Changyou Zhou

Merck

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Christopher Richard Moyes

Merck

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Alexander Pasternak

University of Pennsylvania

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Shankaran Kothandaraman

Merck

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Stephen D. Goble

Merck

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Deodialsingh Guiadeen

Merck

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