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Shankaran Kothandaraman

Merck & Co.

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Publication

Featured researches published by Shankaran Kothandaraman.

Bioorganic & Medicinal Chemistry Letters | 2009

Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.

Shankaran Kothandaraman; Karla L. Donnely; Gabor Butora; Richard Jiao; Alexander Pasternak; Gregori J. Morriello; Stephen D. Goble; Changyou Zhou; Sander G. Mills; Malcolm Maccoss; Pasquale P. Vicario; Julia M. Ayala; Julie A. DeMartino; Mary Struthers; Margaret A. Cascieri; Lihu Yang

A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found to posses potent antagonistic activity.

Archive | 1999

CYCLIC AMINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Charles G. Caldwell; Malcolm Maccoss; Paul E. Finke; Sander G. Mills; Bryan Oates; Shankaran Kothandaraman; Dooseop Kim; Liping Wang

Archive | 2003

Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Richard Jiao; Gregori J. Morriello; Lihu Yang; Stephen D. Goble; Sander G. Mills; Alexander Pasternak; Changyou Zhou; Gabor Butora; Shankaran Kothandaraman; Deodialsingh Guiadeen; Christopher Richard Moyes; Cheng Tang

Archive | 2003

Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity

Richard Jiao; Stephen D. Goble; Sander G. Mills; Gregori J. Morriello; Alexander Pasternak; Lihu Yang; Changyou Zhou; Gabor Butora; Shankaran Kothandaraman; Deodialsingh Guiadeen; Christopher Richard Moyes

Bioorganic & Medicinal Chemistry Letters | 2006

4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.

Gabor Butora; Gregori J. Morriello; Shankaran Kothandaraman; Deodialsingh Guiadeen; Alexander Pasternak; William H. Parsons; Malcolm Maccoss; Pasquale P. Vicario; Margaret A. Cascieri; Lihu Yang

Archive | 2008

Novel 1,8-naphthyridine compounds

Deodialsingh Guiadeen; Jeffrey J. Hale; Shankaran Kothandaraman

Archive | 2005

Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity

Gabor Butora; Deodialsingh Guiadeen; Shankaran Kothandaraman; Malcolm Maccoss; Sander G. Mills; Lihu Yang

Archive | 2004

Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity

Stephen D. Goble; Lihu Yang; Changyou Zhou; Shankaran Kothandaraman; Deodialsingh Guiadeen; Gabor Butora; Alexander Pasternak; Sander G. Mills

Tetrahedron Letters | 2008

An expeditious synthesis of 3-(difluoromethoxy)-and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines

Deodialsingh Guiadeen; Shankaran Kothandaraman; Lihu Yang; Sander G. Mills; Malcolm Maccoss

Tetrahedron Letters | 2009

Concise preparation of 8-trifluoromethyltetrahydro-6H-pyrido [1,2-a] pyrazine-6-one

Shankaran Kothandaraman; Deodialsingh Guiadeen; Gabor Butora; George A. Doss; Sander G. Mills; Malcolm Maccoss; Lihu Yang

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Deodialsingh Guiadeen

Merck

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Sander G. Mills

Merck

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Lihu Yang

Merck

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Gabor Butora

Merck

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Malcolm Maccoss

Merck

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Alexander Pasternak

University of Pennsylvania

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Changyou Zhou

Merck

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Stephen D. Goble

Merck

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Gregori J. Morriello

Merck

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Richard Jiao

Merck

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