Richard M. Soll
Johnson & Johnson Pharmaceutical Research and Development
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Richard M. Soll.
Bioorganic & Medicinal Chemistry Letters | 2008
Jeremy M. Travins; Farah Ali; Hui Huang; Shelley K. Ballentine; Ehab Khalil; Heather Rae Hufnagel; Wenxi Pan; Joan Gushue; Kristi Leonard; Roger F. Bone; Richard M. Soll; Renee L. DesJarlais; Carl Crysler; Nisha Ninan; Jennifer Kirkpatrick; Maxwell D. Cummings; Norman Huebert; Christopher J. Molloy; Michael Gaul; Bruce E. Tomczuk; Nalin Subasinghe
Complement activation has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury, acute respiratory distress syndrome, and acute transplant rejection. Even though the complement cascade provides several protein targets for potential therapeutic intervention only two complement inhibitors have been approved so far for clinical use including anti-C5 antibodies for the treatment of paroxysmal nocturnal hemoglobinuria and purified C1-esterase inhibitor replacement therapy for the control of hereditary angioedema flares. In the present study, optimization of potency and physicochemical properties of a series of thiophene amidine-based C1s inhibitors with potential utility as intravenous agents for the inhibition of the classical pathway of complement is described.
Biotechnology and Bioengineering | 2000
Zhengdong Wu; Jooyoung Kim; Richard M. Soll; Dale S. Dhanoa
A highly efficient and versatile solid-phase synthesis of 2,4-diaminoquinazoline library from 2,4-dichloroquinazolines and amines using 3,5-dimethoxy 4-formylphenoxy-polystyrene resin is described.
Archive | 1995
Dimitris K. Agrafiotis; Roger F. Bone; Francis R. Salemme; Richard M. Soll
Archive | 1997
Dimitris K. Agrafiotis; Roger F. Bone; Francis R. Salemme; Richard M. Soll
Archive | 1996
Dimitris K. Agrafiotis; Roger F. Bone; Francis R. Salemme; Richard M. Soll
Archive | 1997
Dimitris K. Agrafiotis; Roger F. Bone; Francis R. Salemme; Richard M. Soll
Archive | 1996
Carl R. Illig; Richard M. Soll; Joseph M. Salvino; Bruce E. Tomczuk; Tianbao Lu; Nalin L. Subasinghe
Archive | 1997
Bruce E. Tomczuk; Richard M. Soll; Tianbao Lu; Cynthia L. Fedde; Carl R. Illig; Thomas P. Markotan; Thomas P. Stagnaro
Archive | 1996
Tianbao Lu; Carl R. Illig; Bruce E. Tomczuk; Richard M. Soll; Nalin L. Subasinghe; Roger F. Bone
Archive | 1997
Richard M. Soll; Tianbao Lu; Cynthia L. Fedde; Bruce E. Tomczuk; Carl R. Illig