Nalin L. Subasinghe
University of Minnesota
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Publication
Featured researches published by Nalin L. Subasinghe.
Tetrahedron Letters | 1996
Ehab Khalil; Nalin L. Subasinghe; Rodney L. Johnson
Abstract An improved method for the N - tert -butoxycarbonyl protection of the amino functionality of α-alkylated prolines and other sterically hindered α,α-disubstituted amino acids has been developed in which the lipophilic base tetramethylammonium hydroxide is used to solubilize the otherwise insoluble zwitterionic amino acid in acetonitrile, thereby obviating the need for an aqueous medium.
Bioorganic & Medicinal Chemistry Letters | 2018
Mark J. Wall; Nalin L. Subasinghe; Michael P. Winters; Mary Lou Lubin; Michael F.A. Finley; Ning Qin; Michael R. Brandt; Michael P. Neeper; Craig R. Schneider; Raymond W. Colburn; Christopher Flores; Zhihua Sui
A novel series of pyrazolyltetrahydropyran N-type calcium channel blockers are described. Structural modifications of the series led to potent compounds in both a cell-based fluorescent calcium influx assay and a patch clamp electrophysiology assay. Representative compounds from the series were bioavailable and showed efficacy in the rat CFA and CCI models of inflammatory and neuropathic pain.
Tetrahedron Letters | 1992
Nalin L. Subasinghe; Rodney L. Johnson
Abstract The reactivity of α-carboxy-activated dehydroaspartic acid derivativs with various N- and O-nucleophiles is described for the first time. Reaction of amino acid derivatives with Ac-Δ Z Asp(OBu t )-OH ( 4a ) under a variety of coupling conditions gave very poor yields of the resulting dehydroasparyl dipeptides, while the coupling of 4a with oxygen nucleophiles gave very good yields of the dehydroaspartyl esters. In contrast, the coupling of amino acids with Cbz-Δ Z Asp(OBu t )-OH ( 4b ) gave good yields of dehydroaspartyl dipeptides. The formaton of a highly reactive oxazolone intermediate is proposed to explain the low yields of peptide coupling between 4a and amino acids.
Journal of Medicinal Chemistry | 1992
Nalin L. Subasinghe; Marvin K. Schulte; Robert J. Roon; James F. Koerner; Rodney L. Johnson
Journal of Medicinal Chemistry | 1993
Nalin L. Subasinghe; Roger J. Bontems; Edward J. McIntee; Ram K. Mishra; Rodney L. Johnson
Journal of Medicinal Chemistry | 1990
Nalin L. Subasinghe; Marvin K. Schulte; Michael Y. M. Chan; Robert J. Roon; James F. Koerner; Rodney L. Johnson
Archive | 1996
Carl R. Illig; Richard M. Soll; Joseph M. Salvino; Bruce E. Tomczuk; Tianbao Lu; Nalin L. Subasinghe
Archive | 1996
Tianbao Lu; Carl R. Illig; Bruce E. Tomczuk; Richard M. Soll; Nalin L. Subasinghe; Roger F. Bone
Archive | 2003
Nalin L. Subasinghe; Ehab Khalil; Kristi Leonard; Farah Ali; Heather Rae Hufnagel; Jeremy M. Travins; Shelley K. Ballentine; Kenneth T. Wilson; Maxwell D. Cummings; Wenxi Pan; Joan Gushue; Sanath K. Meegalla; Mark Wall; Jinsheng Chen; M. Jonathan Rudolph; Hui Huang
Archive | 1999
Carl R. Illig; Nalin L. Subasinghe; James B. Hoffman; Kenneth J. Wilson; M. Jonathan Rudolph