Rie Shimoju
International University of Health and Welfare
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Publication
Featured researches published by Rie Shimoju.
Autonomic Neuroscience: Basic and Clinical | 2009
Yukie Higashimura; Rie Shimoju; Hitoshi Maruyama; Mieko Kurosawa
The effects of electro-acupuncture (EA) on plasma concentration of glucose and on responsiveness to insulin were examined in an animal model of diabetes, the streptozotocin-treated rat. Two weeks after treatment with streptozotocin, rats were anesthetized with urethane-chloralose and subjected to the EA for 10 min delivered to the tibialis anterior muscle of one side. The stimulation produced no significant changes in plasma glucose concentration. In contrast, EA increased the response of plasma glucose to insulin (0.2 U kg(-1)). The effect of EA on the responsiveness to insulin was abolished by section of both sciatic and femoral nerves ipsilateral to the side of the EA. These results show that EA in diabetic rats has no effect on plasma glucose concentration while it augments the responsiveness to insulin, and we show that this occurs via a mechanism that involves the somatic afferent nerves.
Neuroreport | 2013
Miyo Hori; Rie Shimoju; Ryota Tokunaga; Masato Ohkubo; Shigeki Miyabe; Junji Ohnishi; Kazuo Murakami; Mieko Kurosawa
Adolescent rats emit 50 kHz ultrasonic vocalizations, a marker of positive emotion, during rough-and-tumble play or on tickling stimulation. The emission of 50 kHz ultrasonic vocalizations in response to tickling is suggested to be mediated by dopamine release in the nucleus accumbens; however, there is no direct evidence supporting this hypothesis. The present study aimed to elucidate whether play behavior (tickling) in adolescent rats can trigger dopamine release in the nucleus accumbens with hedonic 50 kHz ultrasonic vocalizations. The effect of tickling stimulation was compared with light-touch stimulation, as a discernible stimulus. We examined 35–40-day-old rats, which corresponds to the period of midadolescence. Tickling stimulation for 5 min significantly increased dopamine release in the nucleus accumbens (118±7% of the prestimulus control value). Conversely, light-touch stimulation for 5 min did not significantly change dopamine release. In addition, 50 kHz ultrasonic vocalizations were emitted during tickling stimulation but not during light-touch stimulation. Further, tickling-induced 50 kHz ultrasonic vocalizations were significantly blocked by the direct application of SCH23390 (D1 receptor antagonist) and raclopride (D2/D3 receptor antagonist) into the nucleus accumbens. Our study demonstrates that tickling stimulation in adolescent rats increases dopamine release in the nucleus accumbens, leading to the generation of 50 kHz ultrasonic vocalizations.
Journal of Physiological Sciences | 2017
Ryota Tokunaga; Rie Shimoju; Hideshi Shibata; Mieko Kurosawa
Noxious cutaneous stimulation increases, whereas innocuous cutaneous stimulation decreases serotonin (5-HT) release in the central nucleus of the amygdala (CeA) in anesthetized rats. In the present study, we investigated the contribution of corticotropin releasing factor (CRF) receptors and gamma-aminobutyric acid (GABA) receptors in the dorsal raphe nucleus (DRN) to those responses. Release of 5-HT in the CeA was monitored by microdialysis before and after 10-min stimulation by pinching or stroking. Increased 5-HT release in the CeA in response to pinching was abolished by CRF2 receptor antagonism in the DRN. Decreased 5-HT release in the CeA in response to stroking was abolished by either CRF1 receptor antagonism or GABAA receptor antagonism in the DRN. These results suggest that opposite responses of 5-HT release in the CeA to noxious versus innocuous stimulation of the skin are due to separate contributions of CRF2, CRF1 and GABAA receptors in the DRN.
Autonomic Neuroscience: Basic and Clinical | 2013
Tomonori Nakano; Rie Shimoju; Hitoshi Maruyama; Mieko Kurosawa
A 37 year-old man presented with the left-sided hypohidrosis over the upper portion of the body. He had anisocoria, generalized areflexia and absence of light-reflex on the right side. Thermal sweating was defective over the left side of the upper body and on the right leg. Acetylcholine focal sweating on the forearm and palmar sweating were markedly reduced on the left side. After immersion of the hands in the hot water (42 °C, 10 min), the right hand showed apparent wrinkling of the palm skin, whereas the left hand showed no wrinkling. Sympathetic flow response was almost symmetric. These investigations support the notion that sympathetic nerve function may exert a crucial role in the production of hand skin wrinkling. However, which of the multiple sympathetic functions is relevant to the hand wrinkling remained unclear. (The Autonomic Nervous System, 50: 53–57, 2013)
Journal of Physiological Sciences | 2012
Kimiko Maruyama; Rie Shimoju; Masato Ohkubo; Hitoshi Maruyama; Mieko Kurosawa
Journal of Physiological Sciences | 2016
Ryota Tokunaga; Rie Shimoju; Noriaki Takagi; Hideshi Shibata; Mieko Kurosawa
Autonomic Neuroscience: Basic and Clinical | 2018
Rie Shimoju; Ryota Tokunaga; Mieko Kurosawa
Autonomic Neuroscience: Basic and Clinical | 2016
Itsuki Imai; Rie Shimoju; Ryota Tokunaga; Mieko Kurosawa
Autonomic Neuroscience: Basic and Clinical | 2014
Ryota Tokunaga; Rie Shimoju; Noriaki Takagi; Mieko Kurosawa
Autonomic Neuroscience: Basic and Clinical | 2013
Mieko Kurosawa; Rie Shimoju; K. Uenishi-Sadakiyo; Hitoshi Maruyama