Rik Vandenberghe
Catholic University of Leuven
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Publication
Featured researches published by Rik Vandenberghe.
Molecular Psychiatry | 2013
Julien Chapuis; Franck Hansmannel; Marc Gistelinck; Anais Mounier; C Van Cauwenberghe; Kristof Van Kolen; F Geller; Y Sottejeau; D Harold; Pierre Dourlen; Benjamin Grenier-Boley; Yoichiro Kamatani; B Delepine; F Demiautte; Diana Zelenika; Nadège Zommer; Malika Hamdane; Céline Bellenguez; J.-F. Dartigues; J-J Hauw; F Letronne; A-M Ayral; K Sleegers; A Schellens; Lies Vanden Broeck; S. Engelborghs; P.P. De Deyn; Rik Vandenberghe; Michael Conlon O'Donovan; Michael John Owen
Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer’s disease (AD) after APOE. We report that BIN1 transcript levels were increased in AD brains and identified a novel 3u2009bp insertion allele ∼28u2009kb upstream of BIN1, which increased (i) transcriptional activity in vitro, (ii) BIN1 expression levels in human brain and (iii) AD risk in three independent case-control cohorts (Meta-analysed Odds ratio of 1.20 (1.14–1.26) (P=3.8 × 10−11)). Interestingly, decreased expression of the Drosophila BIN1 ortholog Amph suppressed Tau-mediated neurotoxicity in three different assays. Accordingly, Tau and BIN1 colocalized and interacted in human neuroblastoma cells and in mouse brain. Finally, the 3u2009bp insertion was associated with Tau but not Amyloid loads in AD brains. We propose that BIN1 mediates AD risk by modulating Tau pathology.
Human Mutation | 2007
Julie van der Zee; Isabelle Le Ber; Sebastian Maurer-Stroh; Sebastiaan Engelborghs; Ilse Gijselinck; Agnès Camuzat; Nathalie Brouwers; Rik Vandenberghe; Kristel Sleegers; Didier Hannequin; Bart Dermaut; Joost Schymkowitz; Dominique Campion; Patrick Santens; Jean-Jacques Martin; Lucette Lacomblez; Tim De Pooter; Karin Peeters; Maria Mattheijssens; Martine Vercelletto; Marleen Van den Broeck; Marc Cruts; Peter Paul De Deyn; Frederic Rousseau; Alexis Brice; Christine Van Broeckhoven
Archive | 2017
Eshwar Gorakhnath Ghumare; Maarten Schrooten; Rik Vandenberghe; Patrick Dupont
Archive | 2017
Maarten Schrooten; Eshwar Gorakhnath Ghumare; Rik Vandenberghe; Patrick Dupont
Archive | 2017
Antonietta Gabriella Liuzzi; Patrick Dupont; Ronald Peeters; Simon De Deyne; Gerrit Storms; Rik Vandenberghe
Presented at: 10th International Conference on Frontotemporal Dementias, Munich, GERMANY. (2016) | 2016
Jessica L. Panman; Lhh Meeter; Egp Dopper; Lize C. Jiskoot; Mjm Bouts; Christiane Möller; R van Minkelen; Raquel Sánchez-Valle; Mircea Balasa; Caroline Graff; Linn Öijerstedt; Jelic; Luisa Benussi; Roberta Ghidoni; Giuliano Binetti; B Barbara; Alessandro Padovani; Daniela Galimberti; Elio Scarpini; Chiara Fenoglio; Robert Laforce; Rik Vandenberghe; I Le Ber; Foudil Lamari; Markus Otto; Jonathan D. Rohrer; David M. Cash; Sar Rombouts; Charlotte E. Teunissen; Janne M. Papma
Presented at: 10th International Conference on Frontotemporal Dementias, Munich, GERMANY. (2016) | 2016
Lieke H.H. Meeter; Elise G.P. Dopper; Lize C. Jiskoot; Raquel Sánchez-Valle; Caroline Graff; Luisa Benussi; Roberta Ghidoni; Yolande A.L. Pijnenburg; B Borroni; Daniela Galimberti; Robert Laforce; Mario Masellis; Rik Vandenberghe; I Le Ber; Markus Otto; R van Minkelen; Janne M. Papma; Serge A.R.B. Rombouts; Mircea Balasa; Linn Öijerstedt; Jelic; D Cash; S Harding; Manuel Jorge Cardoso; Sebastien Ourselin; Katrina M. Dick; Giuliano Binetti; Alessandro Padovani; Elio Scarpini; Chiara Fenoglio
Archive | 2016
Rik Vandenberghe; Eshwar Gorakhnath Ghumare; Laura Seynaeve; Patrick Dupont; Wim Van Paesschen; Tom Theys; Maarten Schrooten
Archive | 2016
Lieven Declercq; Sofie Celen; Joan Lecina; Muneer Ahamed Syed Musthakahmed; Thomas Tousseyn; Rik Vandenberghe; Koen Van Laere; Alfons Verbruggen; Guy Bormans
Archive | 2016
Rita Cacace; T Van den Bossche; J Lippiat; Jonathan Janssens; G De Baets; S. Engelborghs; Anne Sieben; M Vandenbulcke; P De Rijk; Elise Cuyvers; C Van Cauwenberghe; Caroline Robberecht; Lubina Dillen; Céline Merlin; Nathalie Geerts; Rik Vandenberghe; J. J. Martin; P.P. De Deyn; Joost Schymkowitz; Stuart Maudsley; Marc Cruts; J. van der Zee; K Sleegers; C. Van Broeckhoven
Collaboration
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