Rita M. Cantor
Cedars-Sinai Medical Center
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Publication
Featured researches published by Rita M. Cantor.
American Journal of Human Genetics | 1998
Hooman Allayee; Bradley E. Aouizerat; Rita M. Cantor; Geesje M. Dallinga-Thie; Ronald M. Krauss; Christopher D. Lanning; Jerome I. Rotter; Aldons J. Lusis; Tjerk W.A. de Bruin
Small, dense LDL particles consistently have been associated with hypertriglyceridemia, premature coronary artery disease (CAD), and familial combined hyperlipidemia (FCH). Previously, we have observed linkage of LDL particle size with four separate candidate-gene loci in a study of families enriched for CAD. These loci contain the genes for manganese superoxide dismutase (MnSOD), on chromosome 6q; for apolipoprotein AI-CIII-AIV, on chromosome 11q; for cholesteryl ester transfer protein (CETP) and lecithin:cholesterol acyltransferase (LCAT), on chromosome 16q; and for the LDL receptor (LDLR), on chromosome 19p. We have now tested whether these loci also contribute to LDL particle size in families ascertained for FCH. The members of 18 families (481 individuals) were typed for genetic markers at the four loci, and linkage to LDL particle size was assessed by nonparametric sib-pair linkage analysis. The presence of small, dense LDL (pattern B) was much more frequent in the FCH probands (39%) than in the spouse controls (4%). Evidence for linkage was observed at the MnSOD (P=.02), CETP/LCAT (P=.03), and apolipoprotein AI-CIII-AIV loci (P=.005) but not at the LDLR locus. We conclude that there is a genetically based association between FCH and small, dense LDL and that the genetic determinants for LDL particle size are shared, at least in part, among FCH families and the more general population at risk for CAD.
Journal of Genetic Counseling | 1994
Zina H. Tatsugawa; Michelle Fox; Carolyn Y. Fang; Jessica M. Novak; Rita M. Cantor; Harold N. Bass; Christine Dunkel-Schetter; Barbara F. Crandall; Wayne W. Grody
Population-based screening for cystic fibrosis carrier mutations presents a number of challenges for genetic counselors, owing primarily to the inability of current DNA testing technology to identify all possible mutations and the difficulty involved in conveying the concept of residual risk to those patients who test negative. To address these issues, we are conducting a pilot study, as part of a consortium established by the National Center for Human Genome Research, to explore the efficacy, acceptance, and psychosocial impact of various approaches to carrier screening in an ethnically diverse Southern California population. This article reports the patient instructional and screening strategies we developed in the initial phase of the project in order to optimize our chances of answering these questions and delivering this service on a large scale.
Genetic Epidemiology | 1997
Huiying Yang; Yaping Wang; Darlene R. Goldstein; Zhiming Li; Hita Vora; Rita M. Cantor
A two‐stage linkage strategy was employed to identify major genes for a simulated complex disease via a genome scan. The importance of several approaches for improving the ability to locate major genes has been illustrated. These approaches are: adjusting for covariates, ascertaining through multiple affected family members, increasing the sample size, and using multipoint linkage analysis.
Hypertension | 2001
Hooman Allayee; Tjerk W.A. de Bruin; K. Michelle Dominguez; Li S.-C. Cheng; Eli Ipp; Rita M. Cantor; Kelly L. Krass; Eric T.P. Keulen; Bradley E. Aouizerat; Aldons J. Lusis; Jerome I. Rotter
Journal of Clinical Investigation | 1997
Geesje M. Dallinga-Thie; M. Van Linde-Sibenius Trip; Jerome I. Rotter; Rita M. Cantor; X.-D. Bu; Aldons J. Lusis; T. W. A. De Bruin
American Journal of Human Genetics | 1997
Wayne W. Grody; Christine Dunkel-Schetter; Z H Tatsugawa; Michelle Fox; Carolyn Y. Fang; Rita M. Cantor; Jessica M. Novak; Harold N. Bass; Barbara F. Crandall
Journal of Lipid Research | 1999
M. Groenendijk; Rita M. Cantor; N.H.H.C. Blom; Jerome I. Rotter; T.W.A. de Bruin; Geesje M. Dallinga-Thie
Archive | 1999
Betty P. Tsao; Rita M. Cantor; Jerome I. Rotter
Genetic Epidemiology | 1991
Janet D. Elashoff; Rita M. Cantor; Sara Shain; G. P. Vogler
Genetic Epidemiology | 1986
Jerome I. Rotter; Constance M Vadheim; G. M. Petersen; Rita M. Cantor; W. J. Riley; N. K. Maclaren