Robert C. Horn

Central Nervous System Involvement in Whipple's Disease*

The pathologic changes in the brains of two cases of Whipples Disease have been described. The lesions are considered specific and, thus, constitute additional evidence of the systemic nature of the disease.

Cardiac Myxoma. A morphologic and histogenetic appraisal

A histologic study of 31 cardiac myxomas has shown a consistent cell type and growth pattern differing from that seen in thrombi and other cardiac neoplasms. Exaggerated proliferation of the myxoma cells and their polysaccharide production are believed to be the source of the epithelium‐like and gland‐like tissue as well as the polysaccharide rich stroma found in cardiac myxomas. Light‐microscopic, enzyme histo‐chemistry and electron‐microscopic studies support a neoplastic endocardial cell origin for the cardiac myxoma.

Mesonephroma of the ovary. A clinical, morphological, and histogenetic appraisal

The clinical and morphological aspects of 32 ovarian tumors of the type considered to be of mesonephric origin have been studied and compared with carcinoma of the endometrium and carcinomas generally considered to arise from the surface covering cells of the ovary. An origin from pluripotential surface epithelium of the ovary or displaced endometrium is supported by a variety of findings: 1. mixed histologic pattern; 2. association with endometriosis, endometrioid carcinoma, and malignant transformation of the surface‐covering cells of the ovary, and 3. histologic similarity to clear cell endometrial carcinoma and of their metastases to papillary cystadenocarcinoma of the ovary.

PULMONARY ALVEOLAR PROTEINOSIS: REPORT OF THREE CASES

Excerpt Pulmonary alveolar proteinosis, a chronic disease of the lungs of unknown etiology, was recently described as a new entity by Rosen et al.1Although the histologic findings are characteristi...

Malignant potential of polypoid lesions of the colon and rectum

More than half of some 2000 polypoid lesions of the colon and rectum studied in the Department of Pathology of Henry Ford Hospital, over a recent 5‐year period, were diagnosed as adenomatous polyps. Approximately one quarter were considered non‐neoplastic—hyperplastic, mucosal, and inflammatory polyps. Little evidence can be found to support a contention that any of these lesions predispose to the development of cancer; origin of carcinoma in such polyps is believed to be a rare event. The papillary or villous adenoma, on the other hand, is a potentially serious lesion. Although the incidence of progression to frank cancer does not appear great, many papillary adenomas, particularly the larger ones, contain foci of invasive cancer. Additionally, even when they do not, there is a risk of repeated local recurrence unless bowel resection is carried out. It appears that most carcinomas are carcinomas from their inception.

Hypoglycemia associated with extrapancreatic tumors. An immunofluorescent study

The indirect immunofluorescent technique, utilizing guinea pig antibovine insulin and fluorescein‐labelled rabbit antiguinea pig globulin applied to sections and imprints of two mesodermal tumors with associated hypoglycemia, demonstrated the presence of insulin or an antigenically similar substance in die cytoplasm of the tumor cells. A causal relationship between the fluorescent antigen(s) in the tumor and the hypoglycemia was indicated in one instance by the alleviation of the hypoglycemia following the removal of the tumor. The second tumor was inoperable and both hypoglycemia and tumor persisted.