Robert L. Smith | Researchain

Archive Network Publication Hotspot Collaboration

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Robert L. Smith is active.

Explore More

Publication

Featured researches published by Robert L. Smith.

Journal of Medicinal Chemistry | 1985

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives.

Stokker Ge; Hoffman Wf; Alberts Aw; Edward J. Cragoe; A. A. Deana; Gilfillan Jl; Huff Jw; Novello Fc; John D. Prugh; Robert L. Smith

A series of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic (heptanoic) acids and their lactone derivatives have been prepared and tested for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vitro. A systematic exploration of the structure-activity relationships in this series led to the synthesis of (+)-trans-(E)-6-[2-[2,4-dichloro-6-[(4-fluorophenyl) methoxyl]phenyl]ethyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (66(+)), which has one-half of the inhibitory activity of compactin.

Journal of Medicinal Chemistry | 1992

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors

George D. Hartman; Melissa S. Egbertson; Wasyl Halczenko; William L. Laswell; Mark E. Duggan; Robert L. Smith; Adel M. Naylor; Patricia D. Manno; Robert J. Lynch

Journal of Medicinal Chemistry | 1983

2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogues.

A. A. Deana; Stokker Ge; Everett M. Schultz; Robert L. Smith; Edward J. Cragoe; Russo Hf; Watson Ls

Journal of Medicinal Chemistry | 1996

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.

Theresa M. Williams; Terrence M. Ciccarone; Suzanne C. MacTough; Rhonda L. Bock; Michael W. Conner; Joseph P. Davide; Kelly Hamilton; Kenneth S. Koblan; Nancy E. Kohl; Astrid M. Kral; Scott D. Mosser; Charles Omer; David L. Pompliano; Elaine Rands; Michael D. Schaber; Daksha Shah; Francine R. Wilson; Jackson B. Gibbs; Samuel L. Graham; George D. Hartman; Allen Oliff; Robert L. Smith

Journal of Medicinal Chemistry | 1977

Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives

Robert L. Smith; Ta-Jyh Lee; Norman P. Gould; Edward J. Cragoe

Journal of Medicinal Chemistry | 1992

4-substituted thiophene- and Furan-2-sulfonamides as topical carbonic anhydrase inhibitors

George D. Hartman; Wasyl Halczenko; Robert L. Smith; Michael F. Sugrue; Pierre J. Mallorga; Stuart R. Michelson; William C. Randall; Harvey Schwam; John M. Sondey

Journal of Medicinal Chemistry | 1992

Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors.

George D. Hartman; Wasyl Halczenko; John D. Prugh; Robert L. Smith; Michael F. Sugrue; Pierre J. Mallorga; Stuart R. Michelson; William C. Randall; Harvey Schwam; John M. Sondey

Archive | 1978