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Robert L. Smith

University of Maine

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Featured researches published by Robert L. Smith.

Journal of Medicinal Chemistry | 1985

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives.

Stokker Ge; Hoffman Wf; Alberts Aw; Edward J. Cragoe; A. A. Deana; Gilfillan Jl; Huff Jw; Novello Fc; John D. Prugh; Robert L. Smith

A series of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic (heptanoic) acids and their lactone derivatives have been prepared and tested for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vitro. A systematic exploration of the structure-activity relationships in this series led to the synthesis of (+)-trans-(E)-6-[2-[2,4-dichloro-6-[(4-fluorophenyl) methoxyl]phenyl]ethyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (66(+)), which has one-half of the inhibitory activity of compactin.

Journal of Medicinal Chemistry | 1992

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors

George D. Hartman; Melissa S. Egbertson; Wasyl Halczenko; William L. Laswell; Mark E. Duggan; Robert L. Smith; Adel M. Naylor; Patricia D. Manno; Robert J. Lynch

Journal of Medicinal Chemistry | 1983

2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogues.

A. A. Deana; Stokker Ge; Everett M. Schultz; Robert L. Smith; Edward J. Cragoe; Russo Hf; Watson Ls

Journal of Medicinal Chemistry | 1996

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.

Theresa M. Williams; Terrence M. Ciccarone; Suzanne C. MacTough; Rhonda L. Bock; Michael W. Conner; Joseph P. Davide; Kelly Hamilton; Kenneth S. Koblan; Nancy E. Kohl; Astrid M. Kral; Scott D. Mosser; Charles Omer; David L. Pompliano; Elaine Rands; Michael D. Schaber; Daksha Shah; Francine R. Wilson; Jackson B. Gibbs; Samuel L. Graham; George D. Hartman; Allen Oliff; Robert L. Smith

Journal of Medicinal Chemistry | 1977

Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives

Robert L. Smith; Ta-Jyh Lee; Norman P. Gould; Edward J. Cragoe

Journal of Medicinal Chemistry | 1992

4-substituted thiophene- and Furan-2-sulfonamides as topical carbonic anhydrase inhibitors

George D. Hartman; Wasyl Halczenko; Robert L. Smith; Michael F. Sugrue; Pierre J. Mallorga; Stuart R. Michelson; William C. Randall; Harvey Schwam; John M. Sondey

Journal of Medicinal Chemistry | 1992

Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors.

George D. Hartman; Wasyl Halczenko; John D. Prugh; Robert L. Smith; Michael F. Sugrue; Pierre J. Mallorga; Stuart R. Michelson; William C. Randall; Harvey Schwam; John M. Sondey

Archive | 1978

SUBSTITUTED 2-AMINOMETHYLPHENYL SULFAMATES, PROCESS FOR PREPARING, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Robert L. Smith; Edward J. Cragoe; Gerald E. Stokker

Journal of Medicinal Chemistry | 1983

Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.

Mark G. Bock; Edward J. Cragoe; DiPardo Rm; Norman P. Gould; W. J. Holtz; Ta-Jyh Lee; C. M. Robb; Robert L. Smith; James P. Springer; Blaine Eh

Canadian Journal of Chemistry | 1964

ANTINEOPLASTIC AGENTS: X. N-BIS(2-FLUOROETHYL)AMINES

George R. Pettit; Robert L. Smith

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Edward J. Cragoe

Merck

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Mark G. Bock

Novartis

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George D. Hartman

United States Military Academy

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George R. Pettit

Arizona State University

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Gerald E. Stokker

Merck

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Ta-Jyh Lee

Merck

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Wasyl Halczenko

United States Military Academy

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C. M. Robb

Merck

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Norman P. Gould

Merck

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A. A. Deana

United States Military Academy

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