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Dive into the research topics where Robert L. Vernier is active.

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Featured researches published by Robert L. Vernier.


The American Journal of Medicine | 1975

Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis: A new syndrome☆

Robert S. Dobrin; Robert L. Vernier; Alfred J. Fish

We describe two patients with a unique granulomatous syndrome who presented with renal failure secondary to diffuse eosinophilic interstitial nephritis. Both had bilateral anterior uveitis, bone marrow granulomas, hypergammaglobulinemia and an increased sedimentation rate. One patient had lymph node granulomas and an immunoglobulin G (IgG) rheumatoid factor. An extensive investigation for an etiologic agent was unrewarding, and neither patient could be placed into any existing diagnostic category. Over a period of 2 years both patients have experienced improved renal function and dissolution of their bone marrow granulomas.


The New England Journal of Medicine | 1983

Heparan Sulfate–Rich Anionic Sites in the Human Glomerular Basement Membrane: Decreased Concentration in Congenital Nephrotic Syndrome

Robert L. Vernier; David J. Klein; Susan Sisson; John D. Mahan; Theodore R. Oegema; David M. Brown

Recent work suggests that the normal barrier to penetration of the renal glomerular basement membrane by anionic plasma proteins may depend in part on the existence of negatively charged sites within the membrane. We describe an in vitro cytochemical method for the quantitative demonstration of anionic sites in the normal human glomerular basement membrane. In five normal subjects, ranging in age from 10 days to 57 years, the sites were distributed at regular intervals in the lamina rara externa, with a frequency of 23.8 +/- 6.8 sites per 1000-nm length of membrane. A similar distribution was observed in the basement membranes from three normal human fetuses. Ex vivo perfusion of one cadaver kidney revealed a similar distribution of anionic sites. The number of anionic sites in the glomerular basement membranes of five patients with the congenital nephrotic syndrome was reduced to 8.9 +/- 3.7 (P less than 0.001). Prior incubation of sections of normal kidney in purified heparinase resulted in a marked reduction in the number of anionic sites. We conclude that congenital nephrosis results from failure of heparan sulfate--rich anionic sites to develop in the lamina rara externa of the glomerular basement membrane.


The New England Journal of Medicine | 1976

Development of Diabetic Vascular Lesions in Normal Kidneys Transplanted into Patients with Diabetes Mellitus

S. Michael Mauer; Jose Barbosa; Robert L. Vernier; Carl M. Kjellstrand; Theodore J. Buselmeier; Richard L. Simmons; John S. Najarian; Frederick C. Goetz

We examined renal-transplant tissue from 12 diabetic and 28 nondiabetic patients who had had a renal graft for at least two years. In 10 diabetic patients arteriolar hyalinosis lesions developed in the graft. In six these lesions involved both afferent and efferent limbs of glomerular arterioles - a pathological finding virtually diagnostic of diabetes mellitus. In all cases these lesions were present within five years of transplantation. Only three of the 28 nondiabetic patients had hyaline vascular changes (P less than 0.001), which occurred only in rare vessels, did not appear within the first five years after transplantation and did not involve both afferent and efferent arterioles, One diabetic patient had nodular glomerulosclerosis. Thus, the first clearly distinguishable lesion of diabetes to occur with frequency in normal kidneys transplanted into diabetic patients is arteriolar hyalinosis.


The Journal of Pediatrics | 1984

Congenital nephrotic syndrome: Evolution of medical management and results of renal transplantation

John D. Mahan; S. Michael Mauer; Richard K. Sibley; Robert L. Vernier

We analyzed the clinical course, pathologic findings, and results of aggressive medical management and renal transplantation in 41 infants with onset of nephrotic syndrome in the first 3 months of life. All but one infant with congenital onset failed to thrive and had progressive renal insufficiency; 17 were given steroids or cytotoxic drugs or both, without benefit. Severe bacterial infections occurred in 85% of the infants, pyloric stenosis in 12%, gastroesophageal reflux in 8%, and thrombotic events in 10%. All children prior to the era of renal transplantation died before 4 years of age. The last 24 infants received aggressive medical management, which allowed renal transplantation in 17. Two-year patient and graft survival rates were 82% and 71%, respectively. There was no recurrence of the nephrotic syndrome in the children who underwent transplantation. All but one surviving infants has had normal or accelerated growth, although mean height for the group is 3.1 SD below the mean. School and social performance has been normal in 80%. Thus intensive medical therapy combined with renal transplantation offers a very good opportunity for survival with an acceptable quality of life for infants with congenital nephrotic syndrome.


The American Journal of Medicine | 1977

Systemic lupus erythematosus within the first two decades of life

Alfred J. Fish; Edward B. Blau; N. Gunnar Westberg; Barbara A. Burke; Robert L. Vernier; Alfred F. Michael

Forty-nine patients with systemic lupus erythematosus (SLE) during childhood and adolescence presenting over a period of 17 years were followed during treatment with prednisone and azathioprine. The average period of follow-up was 5.7 years. Detailed analyses of clinical parameters of renal function and sequential changes in glomerular abnormalities by percutaneous renal biopsy are reported. Therapy was directed towards normalizing the results of urinalysis and renal function, eliminating proteinuria and maintaining normal serology (normal serum complement and negative antiDNA titers). The 10 year survival of the entire group was 86 per cent. A survival of 73 per cent and 87 per cent over this interval in patients with diffuse and focal proliferative lupus nephritis, respectively, was achieved. The major cause of mortality in this series was infection. It appears that intensive observation and monitoring of serologic parameters in SLE, along with aggressive steroid and immunosuppressive therapy, lead to a prognosis in SLE more favorable than previously reported.


The Journal of Pediatrics | 1977

Postpubertal evaluation of gonadal function following cyclophosphamide therapy before and during puberty.

Richard D. Lentz; Jerry M. Bergstein; Michael W. Steffes; David R. Brown; Konald A. Prem; Alfred F. Michael; Robert L. Vernier

Evaluation of pituitary gonadotropins, gonadal steroids, spermatogenesis, and menstrual function was undertaken in 32 patients (19 males and 13 females) treated with cyclophosphamide because of nephrotic syndrome. Patients were treated before, during, or after puberty. Evaluations took place after or in very late puberty. Spermatogenic dysfunction occurred in six of 15 boys who received the entire course before and during puberty and was probably dose related. Menstrual dysfunction did not occur following treatment of six prepubertal or pubertal girls, though only low total doses were used. Therapy after puberty was associated with spermatogenic dysfunction in all four boys, but did not cause menstrual dysfunction in any of seven women. Tentative guidelines are suggested that many minimize gonadal toxicity when cyclophosphamide is used in children with nephrotic syndrome. Factors of particular importance in the interpretation of gonadotropin determinations and of sperm counts in young cyclophosphamide-treated patients are discussed.


The American Journal of Medicine | 1975

The role of complement, immunoglobulin and bacterial antigen in coagulase-negative staphylococcal shunt nephritis.

R.S. Dobrin; N.K. Day; P.G. Quie; H.L. Moore; Robert L. Vernier; Alfred F. Michael; Alfred J. Fish

We describe three patients with arrested hydrocephalus in whom glomerulonephritis developed secondary to Staphylococcus epidermidis bacteremia from an infected ventriculoatrial shunt. Investigation of the immune-mediated renal disease associated with this chronic infection showed that (1) complement depletion during the acute phase of bacteremia and nephritis was predominantly via the classic pathway; (2) rheumatoid factor was associated with bacteremia, fever, proteinuria and low complement levels; (3) early complement components (C1q, C4, C3), immunoglobulin (predominantly immunoglobulin M [IgM], Staph. epidermidis antigen(s) and electron denxe subendothelial deposits were localized within the renal glomerulus; (4) C1q, and IgM derived from patient serums, were the most prominent in vitro immunoreactants to Staph. epidermidis cell walls; and (5) the causative organisms, Staph. epidermidis, shared common antigens with Staph. aureus, and antibody from patient serums cross reacted with extracts from both of these organisms.


Journal of Pediatric Surgery | 1990

Early bladder outlet obstruction in fetal lambs induces renal dysplasia and the prune-belly syndrome

Ricardo Gonzalez; Yuri Reinberg; Barbara A. Burke; Thomas G. Wells; Robert L. Vernier

A model of posterior urethral valves in fetal lambs was developed in order to evaluate the effect of intrauterine urinary obstruction on the developing kidney. Complete urethral obstruction was induced in five fetal lambs at 43 to 45 days of gestation. Two control fetal lambs underwent sham operations. At full term (140 days), two of the five experimental lambs and both control lambs were available for postmortem examination. Results of gross and histological examination of the control lambs were normal. In contrast, the kidneys of the experimental lambs were markedly asymmetrical in size. Histological examination of the kidneys in experimental lambs showed cystic dilatation of the collecting ducts and occasional cystic dilatation of Bowmans spaces, features compatible with obstruction. Also noted were peripheral cortical cysts and primitive tubules lined with cuboidal epithelium and surrounded by fibromuscular collarettes, characteristic of renal dysplasia. One of the infant lambs had many characteristics of the prune-belly syndrome, including a wrinkled, markedly distended abdomen, deficient abdominal wall musculature, flared chest wall, limb deformities, and undescended testes. These results suggest that early in utero urethral obstruction (at the beginning of the second third of gestation) causes renal dysplasia. The results also support the hypothesis that the prune-belly syndrome results from abdominal distention that occurs early in gestation.


The Journal of Pediatrics | 1974

Avascular necrosis of bone in systemic lupus erythematosus

Jerry M. Bergstein; Cornelius Wiens; Alfred J. Fish; Robert L. Vernier; Alfred F. Michael

A skeletal radiologic survey was performed on 35 patients with systemic lupus erythematosus (SLE) to determine the prevalence of avascular necrosis of bone. Fourteen patients had avascular necrosis of a total of 31 bones. Eight of nine symptomatic sites were in the femoral head or condyles. The most frequently involved area was the femoral condyle, followed in order of frequency by the femoral head, talus, capitulum of the elbow, metatarsals, and the patella. No difference was found in the age of onset of SLE, the duration of prednisone and azathioprine therapy, or the average annual dose of prednisone between patients with and without bone disease. It appears that the development of avascular necrosis of bone may results from interference with the blood supply to the bone due to corticosteriod-induced vascular changes andlor from the vasculitic component of blood vessel alteration in SLE.


Pediatric Nephrology | 1988

Anaphylactoid purpura: characteristics of 16 patients who progressed to renal failure

Timothy E. Bunchman; S. Michael Mauer; Richard K. Sibley; Robert L. Vernier

Renal insufficiency occurs in at least 1.5% of children with anaphylactoid purpura (AP). We reviewed the records of 16 children who developed end-stage renal disease (ESRD group) secondary to AP and matched them for age, era of onset, renal histology, and clinical severity at onset with 16 children who has AP but whose creatinine clearance returned to and remained normal (recovery group). We reviewed creatinine clearances at 1, 3, 5, and 10 years after onset. A creatinine clearance >70 ml/min per 1.73 m2 was present in 50% of the patients in the ESRD group at 3 years and in 25% at 5 years after onset. In contrast, all patients in the recovery group had a creatinine clearance >70 ml/min per 1.73 m2 by 3 years (7 of 16 had a creatinine clearance >125 ml/min per 1.73 m2) and all were normal 95–125 ml/min per 1.73 m2) by 5 years. Thus, the presence of an increased creatinine clearance (>125 ml/min per 1.73 m2) at 3 years predicted recovery, while failure to reach a creatinine clearance of >70 ml/min per 1.73 m2 at 3 years predicted progression to ESRD. There was no evidence of recurrent systemic AP or nephritis in the 14 patients who underwent renal allograft transplantation. We conclude that long-term evaluation of patients over many years is required to identify those who will progress to ESRD from AP and that recurrence of AP in the renal transplant is uncommon.

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Susan Sisson

University of Minnesota

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Fred G. Smith

University of California

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