Robert W. Sweetow

The tinnitus functional index: development of a new clinical measure for chronic, intrusive tinnitus.

Objectives: Chronic subjective tinnitus is a prevalent condition that causes significant distress to millions of Americans. Effective tinnitus treatments are urgently needed, but evaluating them is hampered by the lack of standardized measures that are validated for both intake assessment and evaluation of treatment outcomes. This work was designed to develop a new self-report questionnaire, the Tinnitus Functional Index (TFI), that would have documented validity both for scaling the severity and negative impact of tinnitus for use in intake assessment and for measuring treatment-related changes in tinnitus (responsiveness) and that would provide comprehensive coverage of multiple tinnitus severity domains. Design: To use preexisting knowledge concerning tinnitus-related problems, an Item Selection Panel (17 expert judges) surveyed the content (175 items) of nine widely used tinnitus questionnaires. From those items, the Panel identified 13 separate domains of tinnitus distress and selected 70 items most likely to be responsive to treatment effects. Eliminating redundant items while retaining good content validity and adding new items to achieve the recommended minimum of 3 to 4 items per domain yielded 43 items, which were then used for constructing TFI Prototype 1. Prototype 1 was tested at five clinics. The 326 participants included consecutive patients receiving tinnitus treatment who provided informed consent—constituting a convenience sample. Construct validity of Prototype 1 as an outcome measure was evaluated by measuring responsiveness of the overall scale and its individual items at 3 and 6 mo follow-up with 65 and 42 participants, respectively. Using a predetermined list of criteria, the 30 best-functioning items were selected for constructing TFI Prototype 2. Prototype 2 was tested at four clinics with 347 participants, including 155 and 86 who provided 3 and 6 mo follow-up data, respectively. Analyses were the same as for Prototype 1. Results were used to select the 25 best-functioning items for the final TFI. Results: Both prototypes and the final TFI displayed strong measurement properties, with few missing data, high validity for scaling of tinnitus severity, and good reliability. All TFI versions exhibited the same eight factors characterizing tinnitus severity and negative impact. Responsiveness, evaluated by computing effect sizes for responses at follow-up, was satisfactory in all TFI versions. In the final TFI, Cronbach’s alpha was 0.97 and test–retest reliability 0.78. Convergent validity (r = 0.86 with Tinnitus Handicap Inventory [THI]; r = 0.75 with Visual Analog Scale [VAS]) and discriminant validity (r = 0.56 with Beck Depression Inventory-Primary Care [BDI-PC]) were good. The final TFI was successful at detecting improvement from the initial clinic visit to 3 mo with moderate to large effect sizes and from initial to 6 mo with large effect sizes. Effect sizes for the TFI were generally larger than those obtained for the VAS and THI. After careful evaluation, a 13-point reduction was considered a preliminary criterion for meaningful reduction in TFI outcome scores. Conclusions: The TFI should be useful in both clinical and research settings because of its responsiveness to treatment-related change, validity for scaling the overall severity of tinnitus, and comprehensive coverage of multiple domains of tinnitus severity.

Cognitive aspects of tinnitus patient management.

Despite the availability of several management procedures for tinnitus, many audiologists seem reluctant to engage in long-term rehabilitation of patients. Tinnitus patients are somewhat similar to chronic pain patients in that both groups suffer from intractable symptoms. A technique which has been effectively utilized in helping pain patients cope with their problems is cognitive-behavioral therapy. This approach can be applied with considerable success to tinnitus patients with the emphasis placed on treating the patients reaction to tinnitus rather than the tinnitus itself. To accomplish this, maladaptive behaviors and thought patterns must be identified and then systematically altered via a program specifically designed for the individual. This procedure is analogous to many precepts governing aural rehabilitation.

Variables predicting outcomes on listening and communication enhancement (LACE TM )

Results from a large study of adults who completed a randomized crossover study of listening and communication enhancement (LACETM) training were analysed to observe trends. The objective of this study was to determine predictors for greatest improvement following this four-week adaptive auditory training and aural rehabilitation program. Subjects with the poorest scores on the baseline tests, particularly those with the greatest degree of hearing loss, poorest scores on measures of degraded and competing speech, and those with the highest hearing handicap scores, were more likely to have greater improvement overall. However, there was considerable variability among the subjects, and some subjects’ positive subjective reports belie smaller overall measured gains. Information collected from both the testing and the counseling of the patient should be taken into consideration when determining whether to proceed with LACE™ training.

Technologic Advances in Aural Rehabilitation: Applications and Innovative Methods of Service Delivery

The level of interest in aural rehabilitation has increased recently, both in clinical use and in research presentations and publications. Advances in aural rehabilitation have seen previous techniques such as speech tracking and analytic auditory training reappear in computerized forms. These new delivery methods allow for a consistent, cost-effective, and convenient training program. Several computerized aural rehabilitation programs for hearing aid wearers and cochlear implant recipients have recently been developed and were reported on at the 2006 State of the Science Conference of the Rehabilitation Engineering Research Center on Hearing Enhancement at Gallaudet University. This article reviews these programs and outlines the similarities and differences in their design. Another promising area of aural rehabilitation research is the use of pharmaceuticals in the rehabilitation process. The results from a study of the effect of d-amphetamine in conjunction with intensive aural rehabilitation with cochlear implant patients are also described.

Transient evoked otoacoustic emissions: feasibility in the nursery.

Objective: To assess the feasibility of obtaining transient‐evoked otoacoustic emissions (TEOAEs) directly in the nursery, to examine the nature of failures in this population, and to determine the time requirements for this test relative to the auditory brain stem response (ABR). Design: TEOAEs and ABRs were recorded from 149 ears, at bedside, in the recovery or intensive care nursery. Subjects were selected according to the risk criteria developed by the Joint Committee on Infant Hearing(1991). Parametric and nonparametric statistical procedures were conducted to describe demographics and test results, to evaluate TEOAE measures by subgroups, and to compare infants by pass/fail outcome. Multivariate techniques were applied to the data to test implicit hypotheses regarding the source of TEOAE failures. In addition, the time required to carry out each test was evaluated in an analysis of variance design. Results: 63.5% of the ears studied passed both procedures, 5% failed both, and 31.5% passed the ABR but failed the TEOAE. Although infants who failed the TEOAE had lower birthweights, shorter gestational periods, and were younger at the time of testing, no statistical differences were found for nursery(intensive care nursery/recovery), bed type (isolette/open crib), ear(left/right), or gender. Infants <38 wk postconceptional age had smaller TEOAE responses and lower noise levels than did those >37 wk. There were no differences in environmental noise levels (at the microphone) for passed or failed ears or whether infants were in isolettes or open cribs. Statistically prolonged ABR wave I latencies (Z‐scores) at 60 and 30 dB among infants who passed the ABR but failed the TEOAE indicated some obstruction to the acoustic stimulus, whereas TEOAE noise measures neither distinguished these groups nor identified this condition. Three summary times involved in the performance of these tests were obtained: (a) actual test time, measured from start to completion of data collection with a stopwatch; (b) total test time, defined by the actual test time plus the respective preparation, setup, and cleanup (ABR) time; and (c) time reported by the computer system during intrinsic sampling. There were no significant differences in actual or total test times, but these values were distinguished from the machine time, which represented an underestimate of the time required to effectively conduct each test. Conclusions: These findings show that TEOAEs can be acquired in the nursery, but the high false‐positive rate suggests that alternative or additional screening methods, for example, the ABR, must also be available. It must be recognized that TEOAE failures increase test time, thereby negating any savings relative to ABR screening alone.

Phase III results with a totally implantable piezoelectric middle ear implant: Speech audiometry, spatial hearing and psychosocial adjustment

Objective To evaluate the treatment efficacy of an electromechanical middle ear amplifier implant (AI) in patients with chronic moderate-to-severe sensorineural hearing loss (SNHL). The AI is a piezoelectric system with a sound processor and a rechargeable battery within a hermetically sealed titanium canister. Its titanium-sealed microphone is placed in the bony region of the ear canal. The incus-coupled transducer (actuator), which is also inside a titanium casing, is fastened to the adjacent bone. Material and Methods This was a phase III study comprising 20 intention-to-treat patients. Telemetrical adjustments followed electromechanical amplifier implantations. We used a word recognition test as our primary efficacy measure (Freiburg Speech Recognition Test; DIN 45621). Secondary efficacy measures were the sentence comprehension test (Goettinger Satztest, 1996) for auditory orientation within noisy and quiet environments and a psychosocial adjustment test (Gothenburg Profile Test, 1998). The 6-month follow-up comprised a complete medical examination. Nineteen patients completed the study (per-protocol patients; 100% reference). Results Seventeen patients (89%) demonstrated improved binaural recognition of phonetically balanced monosyllables. Fourteen postoperative patients (74%) attained a perfect score (100%) on this test, compared to only 3 preoperative patients (16%). Thirteen patients (68%) reached the sentence recognition threshold at a 2:1 dB signal-to-noise ratio during noisy trials. Correct identification of the noise source direction in the horizontal plane occurred in 89% of the trials. The Gothenburg Profile Test scores showed that the subjective evaluation of hearing, orientation, social behavior and self-confidence increased from 48% to 88%. Three patients did not benefit from the implant. Conclusion Treatment of SNHL with a totally implantable hearing system can be an efficient method for those patients unable to wear hearing aids. However, in order to avoid implantation in non-responders, there is a need for more specific audiological indication criteria.

Preliminary evaluation of a novel bone-conduction device for single-sided deafness.

Hypothesis: A new intraoral bone-conduction device has advantages over existing bone-conduction devices for reducing the auditory deficits associated with single-sided deafness (SSD). Background: Existing bone-conduction devices effectively mitigate auditory deficits from single-sided deafness but have suboptimal microphone locations, limited frequency range, and/or require invasive surgery. A new device has been designed to improve microphone placement (in the ear canal of the deaf ear), provide a wider frequency range, and eliminate surgery by delivering bone-conduction signals to the teeth via a removable oral appliance. Methods: Forces applied by the oral appliance were compared with forces typically experienced by the teeth from normal functions such as mastication or from other appliances. Tooth surface changes were measured on extracted teeth, and transducer temperature was measured under typical use conditions. Dynamic operating range, including gain, bandwidth, and maximum output limits, were determined from uncomfortable loudness levels and vibrotactile thresholds, and speech recognition scores were measured using normal-hearing subjects. Auditory performance in noise (Hearing in Noise Test) was measured in a limited sample of SSD subjects. Overall comfort, ease of insertion, and removal and visibility of the oral appliance in comparison with traditional hearing aids were measured using a rating scale. Results: The oral appliance produces forces that are far below those experienced by the teeth from normal functions or conventional dental appliances. The bone-conduction signal level can be adjusted to prevent tactile perception yet provide sufficient gain and output at frequencies from 250 to 12,000 Hz. The device does not damage tooth surfaces nor produce heat, can be inserted and removed easily, and is as comfortable to wear as traditional hearing aids. The new microphone location has advantages for reducing the auditory deficits caused by SSD, including the potential to provide spatial cues introduced by reflections from the pinna, compared with microphone locations for existing devices. Conclusion: A new approach for SSD has been proposed that optimizes microphone location and delivers sound by bone conduction through a removable oral appliance. Measures in the laboratory using normal-hearing subjects indicate that the device provides useful gain and output for SSD patients, is comfortable, does not seem to have detrimental effects on oral function or oral health, and has several advantages over existing devices. Specifically, microphone placement is optimized for reducing the auditory deficit caused by SSD, frequency bandwidth is much greater, and the system does not require surgical placement. Auditory performance in a small sample of SSD subjects indicated a substantial advantage compared with not wearing the device. Future studies will involve performance measures on SSD patients wearing the device for longer periods.

Audiometric asymmetry and tinnitus laterality.

To identify an optimal audiometric asymmetry index for predicting tinnitus laterality.

An overview of common procedures for the management of tinnitus patients

management procedures most frequently used by non-physician hearing healthcare providers (HHPs). Subjective tinnitus is a symptom associated with practically every known otologic disorder. Evidence suggests that when there is a peripheral attenuation of acoustic stimulation (as would be caused by hearing loss) there is also an increase in central auditory nervous system activity at numerous anatomical sites, including the dorsal cochlear nucleus, inferior colliculus, and auditory cortex.1,2 This has been verified via neuroimaging.3 Further support for a central model of tinnitus is that patients whose symptoms are presumably caused by cochlear damage from noise exposure may still “hear” tinnitus following the surgical destruction of the auditory nerve.

The use of fractal tones in tinnitus patient management

A variety of noises have been employed for decades in an effort to facilitate habituation, mask, or suppress tinnitus. Many of these sounds have reportedly provided benefit, but success has not been universal. More recently, musical stimuli have been added as a sound therapy component. The potential advantages of using such stimuli, in particular fractal tones, in combination with amplification are discussed in this paper.