Robin D. Powell

Relationship between Activity of Pyruvate Kinase and Age of the Normal Human Erythrocyte

MATURE erythrocytes of human beings derive energy chiefly through anaerobic glycolysis. Pyruvate kinase catalyses a key1,2, adenosine triphosphate-generating glycolytic reaction. We have examined the relationship between the activity of pyruvate kinase and the age of the normal human red cell.

Effects of diaphenylsulphone (dapsone) against plasmodium vivax of South West Pacific origin

Abstract Studies were carried out to assess the blood schizontocidal effects of dapsone in children with naturally acquired P. vivax infections and to assess its blood schizontocidal and possible tissue schizontocidal effects in adult volunteers infected with the Chesson strain of P. vivax . The effects against P. vivax of South West Pacific origin were unimpressive.

Intravenous Glucose Tolerance in Negro Men Deficient in Glucose-6-Phosphate Dehydrogenase

Abstract Standard intravenous, cortisone-modified intravenous and oral glucose tolerance tests were carried out in 10 Negro men with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and in 10 normal Negro men. The mean age and weight were identical in the G-6-PD-deficient and the normal men. No significant differences were demonstrated between mean blood glucose levels in the G-6-PD-deficient men and those in the normal men during standard oral glucose tolerance tests. In contrast, the results of both the standard and the cortisone-modified intravenous glucose tolerance tests revealed significantly higher blood glucose levels in the G-6-PD-deficient men at 20, 30, 40, 50 and 60 minutes. Despite the higher blood glucose levels, mean serum immunoreactive insulin levels in the G-6-PD-deficient men were not significantly different from those in the normal men. Additional evidence of altered glucose metabolism associated with G-6-PD deficiency is thus provided.

Studies on the Activity of Pyruvate Kinase in Hemolysates of Normal and Glucose-6-Phosphate Dehydrogenase-deficient Erythrocytes.

Excerpt Pyruvate kinase catalyzes a key, adenosine triphosphate-generating step of anaerobic glycolysis. This pathway constitutes the main source of energy in mature erythrocytes of human beings. W...