Rodrigo César Reis de Oliveira

Autoimmunity in hepatitis C virus carriers: Involvement of ferritin and prolactin

BACKGROUND Ferritin and prolactin have been associated with active autoimmune diseases as systemic lupus erythematosus and autoantibody production, but have been little studied in viral infections that present autoimmunity. OBJECTIVE To investigate the association of these two autoimmune mediators with the presence of cryoglobulinaemia and non-organ-specific autoantibodies (RF, SMA, β2GPI IgA antibody and ANA) in Brazilian individuals chronically infected with hepatitis C virus (HCV). METHODS Ninety-nine patients were evaluated. Ferritin and prolactin levels were determined by chemiluminescent immunoassays. RESULTS Hyperprolactinemia was found in 10 (six men and four women) out of 99 (10.1%) hepatitis C patients. Thirty-eight out of 99 (38.4%) HCV carriers had hyperferritinemia (median level 385ng/mL). Neither hyperprolactinemia nor hyperferritinemia was associated with cryoglobulinaemia or non-organ-specific autoantibodies (p>.05). There was an association between hyperprolactinemia and the infection with HCV genotype 3 (p<.01). Ferritin and ALT levels were correlated (p<.05). CONCLUSION Our results suggest that neither prolactin nor ferritin is involved with the extra-hepatic manifestation of autoimmunity observed in HCV carriers.

UMA PROPOSTA PARA ANÁLISE DA ADOÇÃO DE TECNOLOGIAS DA INFORMAÇÃO EM MICRO E PEQUENAS EMPRESAS A PARTIR DA ADAPTAÇÃO DO MODELO TOE (TECHNOLOGY, ORGANIZATION AND ENVIRONMENT)

Este ensaio teorico tem como objetivo propor a adaptacao do modelo TOE - Technology, Organization and Environment para analise da adocao de tecnologias da informacao em micro e pequenas empresas. Nesse sentido, o presente ensaio busca evidenciar a relevância do tema e do objeto de analise, tanto a partir da perspectiva teorica quanto da pragmatica, ja que sao organizacoes essenciais do ponto de vista economico e social. A partir da proposicao, sugere-se que pesquisas futuras venham a aplicar o modelo para que se verifique a riqueza exploratoria de analise em organizacoes, principalmente as MPE.

Clinical and laboratory aspects of dyslipidemia in Brazilian women with systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is associated with dyslipidemia, atherosclerosis, and cardiovascular disease. In this study, we investigated the presence of dyslipidemia in Brazilian SLE patients by evaluating their lipid profile and immune status, including the production of autoantibodies and cytokines involved in atherogenesis. Ninety-four female SLE patients participated in this study and, based on their lipid profile, were classified as dyslipidemic or not. All were tested for antinuclear antibodies (ANAs), antiphospholipid antibodies, and autoantibodies to extractable nuclear antigens and double-stranded DNA. Serum levels of apolipoproteins A and B, C3, C4, and C-reactive protein were measured, as well as serum levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-10. Lupus activity was scored according to the Systemic Lupus Erythematosus Disease Activity Index 2000. Sixty-nine patients (73.4%) had dyslipidemia, and the remaining 25 patients (26.6%) were non-dyslipidemic. Lupus activity was correlated with non-high-density lipoprotein cholesterol and triglyceride (TG) levels (non-HDL-C, r = 0.34 and p = 0.0043 and r = 0.46 and p < 0.0001, respectively). Atherogenic indexes apolipoprotein B/apolipoprotein A and TG:HDL-C ratios were higher in dyslipidemic women, and TG:HDL was correlated with disease activity (r = 0.40, p = 0.0007). IL-6, TNF-α, and IL-10 levels were similar between groups; however, a positive correlation between IL-6 and CRP levels was only observed in the group with dyslipidemia (r = 0.55, p < 0.0001). Female Brazilian SLE patients present a high prevalence of dyslipidemia and exhibit a higher risk of cardiovascular diseases as compared with female SLE patients without dyslipidemia and healthy individuals.

Therapy for bisphosphonate-related osteonecrosis of the jaw: a systematic review

Felipe Lara Francischetti*, Antônio Márcio Lima Ferraz Júniorb, Rodrigo Guerra de Oliveirab,c, Tomislav Badeld, Archie Morrisone, Raquel Zita Gomesf a School of Medical and Health Sciences of Juiz de Fora, SUPREMA/JF– MG, Brasil b Dentistry program of SUPREMA/JF and Hospital e Maternidade Therezinha de Jesus (HMTJ), Brasil c Implantology program of SUPREMA/JF and Hospital e Maternidade Therezinha de Jesus HMTJ), Brasil d Department of Prosthodontics, School of Dental Medicine, University of Zagreb, Croatia e Faculty of Dentistry, Dalhousie University Halifax Nova Scotia, Canada f Faculdade de Medicina Dentária da Universidade do Porto (FMDUP), Portugal

Treinamento e Participação dos Usuários no Desenvolvimento de Sistemas: Desafios para a Adoção de Tecnologia da Informação

Este artigo visa analisar o treinamento e a participacao de usuarios nos processos de adocao de tecnologias da informacao em prefeituras. A pesquisa foi realizada por meio de uma survey junto a 60 prefeituras do Estado de Sergipe e os resultados evidenciam que, apesar de praticamente todos os respondentes terem passado por treinamento, boa parte deles avalia de forma negativa os treinamentos recebidos. Embora se sintam seguros com o uso, a maioria dos participantes ainda nao tem seguranca ao lidar com os relatorios disponibilizados pelo sistema de informacao adotado. Alem disso, os respondentes apontam a necessidade de melhorias na qualificacao dos instrutores que ministraram os treinamentos. Os resultados evidenciam ainda que os participantes entendem como essencial sua participacao no processo de desenvolvimento dos sistemas de informacao que utilizam. Tal participacao tem como principais beneficios percebidos pelos usuarios: a flexibilizacao e melhoria na facilidade de uso dos sistemas, a eliminacao de caracteristicas desnecessarias, a diminuicao da resistencia ao sistema e o aumento da satisfacao dos usuarios com sua implantacao. A pesquisa mostra que a adocao de sistemas de informacao depende tanto de treinamento quanto da participacao dos usuarios no processo de desenvolvimento. DOI: 10.21714/1679-18272016v14Esp2.p200-212

Adoption of Information Technology: bibliometric study of seven years (2009-2015) of CONTECSI, ENANPAD and ENADI

This study aims to analyze the publications of the last seven years on the topic Adoption of Information Technology (ADIT). To this end, we performed a bibliometric study of the annals of three of the main events of the Brazil in the area of ​​ Information Technology Management. The study was possible due to the indexation of the annals of the events that led to the filtering of articles that address the issue, for further analysis of the researchers. The results show that the years 2009 and 2015 were the most fruitful in producing articles on ADIT in Brazil, from the events in the main subject (CONTECSI, ENANPAD and ENADI). It is noteworthy that, as the literature has stated, most of the studies address the individual level of analysis, while a smaller portion has as its agenda the phenomenon of information technology adoption at the organizational level. It is evident that the issue remains agenda of several studies in Brazil and it is essential that they continue to theoretical and methodological developments.

High Avidity dsDNA Autoantibodies in Brazilian Women with Systemic Lupus Erythematosus: Correlation with Active Disease and Renal Dysfunction

We investigated in Brazilian women with SLE the prevalence and levels of high avidity (HA) dsDNA antibodies and tested their correlation with lupus activity and biomarkers of renal disease. We also compared these correlations to those observed with total dsDNA antibodies and antibodies against nucleosome (ANuA). Autoantibodies were detected by ELISA, while C3 and C4 levels were determined by nephelometry. Urine protein/creatinine ratio was determined, and lupus activity was measured by SLEDAI-2K. The prevalence of total and HA dsDNA antibodies was similar to but lower than that verified for ANuA. The levels of the three types of antibodies were correlated, but the correlation was more significant between HA dsDNA antibodies and ANuA. High avidity dsDNA antibodies correlated positively with ESR and SLEDAI and inversely with C3 and C4. Similar correlations were observed for ANuA levels, whereas total dsDNA antibodies only correlated with SLEDAI and C3. The levels of HA dsDNA antibodies were higher in patients with proteinuria, but their levels of total dsDNA antibodies and ANuA were unaltered. High avidity dsDNA antibodies can be found in high prevalence in Brazilian women with SLE and are important biomarkers of active disease and kidney dysfunction.