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Ronald Merriman

Pfizer

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Publication

Featured researches published by Ronald Merriman.

Bioorganic & Medicinal Chemistry Letters | 2008

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).

Joseph Scott Warmus; Cathlin Marie Flamme; Lu Yan Zhang; Stephen Douglas Barrett; Alexander James Bridges; Huifen Chen; Richard Gowan; Michael Kaufman; Judy Sebolt-Leopold; Wilbur R. Leopold; Ronald Merriman; Jeffrey F. Ohren; Alexander Pavlovsky; Sally Przybranowski; Haile Tecle; Heather Valik; Christopher Whitehead; Erli Zhang

This paper reports a second generation MEK inhibitor. The previously reported potent and efficacious MEK inhibitor, PD-184352 (CI-1040), contains an integral hydroxamate moiety. This compound suffered from less than ideal solubility and metabolic stability. An oxadiazole moiety behaves as a bioisostere for the hydroxamate group, leading to a more metabolically stable and efficacious MEK inhibitor.

Cancer Research | 1979

Reversible Inhibition by Retinoids of 3-Methylcholanthrene-induced Neoplastic Transformation in C3H/10T½ Clone 8 Cells

Ronald Merriman; John S. Bertram

Molecular Cancer Therapeutics | 2003

Modulation of Histone Acetylation by [4-(Acetylamino)-N-(2-Amino-phenyl) Benzamide] in HCT-8 Colon Carcinoma

Alan J. Kraker; Craig A. Mizzen; Brian G. Hartl; Johnson Miin; C. David Allis; Ronald Merriman

Archive | 1999

Chemotherapy of cancer with actyldinaline in combination with gemcitabine capecitabine or cisplatin

William Richard Grove; Wayne Daniel Klohs; Ronald Merriman

Journal of Medicinal Chemistry | 2007

4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

Julie A. Spicer; Gordon W. Rewcastle; Michael Kaufman; Shannon L. Black; Mark Stephen Plummer; William A. Denny; John Quin; Aurash Shahripour; Stephen Douglas Barrett; Christopher Whitehead; Jared Bruce John Milbank; Jeffrey F. Ohren; Richard Gowan; Charles Omer; Heidi S. Camp; Nadia Esmaeil; Kelley Moore; Judith Sebolt-Leopold; Sally Pryzbranowski; Ronald Merriman; Daniel F. Ortwine; Joseph Scott Warmus; Cathlin Marie Flamme; and Alexander G. Pavlovsky; Haile Tecle

Journal of Medicinal Chemistry | 2000

Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives

Raymond J. Bergeron; Ralf Müller; Jörg Bussenius; James S. McManis; Ronald Merriman; Richard E. Smith; Hua Yao; William R. Weimar

Cancer Research | 2004

The biological profile of PD 0325901: A second generation analog of CI-1040 with improved pharmaceutical potential

Judith Sebolt-Leopold; Ronald Merriman; Charles Omer; Haile Tecle; Alex Bridges; Wayne Daniel Klohs; Cho-Ming Loi; Heather Valik; Sally Przybranowski; Mark Meyer; Wilbur R. Leopold

Cancer Research | 2004

PK/PD modeling of biomarker (p-ERK) response and tumor growth to PD 0325901 in a human tumor xenograft mouse model

Jeffrey R. Koup; Jing Liu; Cho-Ming Loi; Curtis T. Howard; Keri Van Becelaere; Sally Przybranowski; Justin Walton; Judith Sebolt-Leopold; Ronald Merriman

Archive | 2002

Combination of acetyldinaline and docetaxel

William Richard Grove; Ronald Merriman

Cancer Research | 2004

Synthesis and SAR development of PD 0325901, a potent and highly bioavailable MEK inhibitor.

Michael Kaufman; Stephen Douglas Barrett; Cathlin Marie Flamme; Joseph Scott Warmus; Yvonne Smith; Manoj Cheriyan; Lu-Yan Zhang; Haile Tecle; Judith Sebolt-Leopold; Heather Valik; Richard Gowan; Keri Van Becelaere; Ronald Merriman; Sally Przybranowski; Jeffrey F. Ohren; Christopher Whitehead; Wilbur R. Leopold; Ellen M. Dobrusin; Alexander James Bridges

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Haile Tecle

Pfizer

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Sally Przybranowski

Pfizer

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Cathlin Marie Flamme

Pfizer

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Christopher Whitehead

Pfizer

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Heather Valik

Pfizer

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Jeffrey F. Ohren

Pfizer

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Joseph Scott Warmus

Pfizer

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Judith Sebolt-Leopold

University of Michigan

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Michael Kaufman

Pfizer

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Richard Gowan

Pfizer

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