Ronald Mierzwa
Schering-Plough
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Publication
Featured researches published by Ronald Mierzwa.
Bioorganic & Medicinal Chemistry Letters | 1995
Stephen J. Coval; Michael A. Conover; Ronald Mierzwa; Arthur King; Mohindar S. Puar; David W. Phife; Jin-Keon Pai; Robert E. Burrier; Ho-Sam Ahn; George Boykow; Mahesh Patel; Shirley A. Pomponi
Abstract Wiedendiol-A and -B, novel sesquiterpene-hydroquinones which inhibit cholesteryl ester transfer protein (CETP), have been isolated from the marine sponge Xestospongia wiedenmayeri. Additional related marine natural products were also evaluated for CETP inhibition. Compounds that inhibit the activity of CETP may find utility as antiatherosclerosis therapy.
Tetrahedron Letters | 1996
Min Chu; Ronald Mierzwa; Imbi Truumees; Arthur King; Mahesh Patel; Raymond Berrie; Andrea Hart; Nancy Butkiewicz; Bimalendu Dasmahapatra; Tze-Ming Chan; Mohindar S. Puar
Abstract A novel hepatitis C virus (HCV) proteinase inhibitor, Sch 68631 ( 1 ), was isolated from the fermentation culture broth of Streptomyces sp. The structure of 1 was elucidated by analyses of spectroscopic data and shown to be a new member of the phenanthrenequinone family of compounds.
Tetrahedron Letters | 1993
Min Chu; Ronald Mierzwa; Imbi Truumees; Frank Gentile; Mahesh Patel; Vincent P. Gullo; Tze-Ming Chan; Mohindar S. Puar
Abstract Diketopiperazines, Sch 54794 and Sch 54796, have been isolated from a fungal fermentation. The structures of these compounds have been established based on spectroscopic data analysis. Sch 54794 exhibited inhibitory activity in the platelet activating factor (PAF) assay.
Bioorganic & Medicinal Chemistry Letters | 2003
Shu-Wei Yang; Alexei Buivich; Tze-Ming Chan; Michelle Smith; Jean E. Lachowicz; Shirley A. Pomponi; Amy E. Wright; Ronald Mierzwa; Mahesh Patel; Vincent P. Gullo; Min Chu
Bioassay-guided fractionation of an active fraction from a marine sponge Topsentia sp. in our marine fraction library (MFL) led to the isolation and identification of halistanol sulfate (1) and a new sterol sulfate Sch 572423 (2). Compounds 1 and 2 were identified as P2Y(12) inhibitors with IC(50) of 0.48 and 2.2 microM, respectively. The general method of purification for the MFL library and the structure elucidation of compound 2 are described.
Tetrahedron Letters | 1997
Chu Min; Ronald Mierzwa; Imbi Truumees; Arthur King; Elpida Sapidou; Ellen Barrabee; Joseph Terracciano; Mahesh Patel; Vincent P. Gullo; Robert E. Burrier; Pradip R. Das; Stanley Mittelman; Mohindar S. Puar
Abstract A novel spirocoumaranone, Sch 202596 ( 1 ), was isolated from the fermentation broth of Aspergillus sp. The isolation, structure elucidation and stereochemistry of 1 are described.
Bioorganic & Medicinal Chemistry Letters | 1999
Min Chu; Ronald Mierzwa; Ling He; Arthur King; Mahesh Patel; John Pichardo; Andrea Hart; Nancy Butkiewicz; Mohindar S. Puar
A new hepatitis C virus (HCV) protease inhibitor designated as Sch 351633 (1) was isolated from the fungus, Penicillium griseofulvum. Structure elucidation of 1 was accomplished by analysis of spectroscopic data, which determined compound 1 to be a bicyclic hemiketal lactone. Compound 1 exhibited inhibitory activity in the HCV protease assay with an IC50 value of 3.8 microg/mL.
Phytochemistry | 1992
Michael A. Conover; Ronald Mierzwa; Arthur King; David Loebenberg; W. Robert Bishop; Mohindar S. Puar; Mahesh Patel; Stephen J. Coval; Joseph Hershenhorn; Gary A. Strobel
Abstract Usnic acid amide, a phytotoxin related to (−)-usnic acid and (−)-cercosporamide, has been isolated from the cassava fungal pathogen Cercosporidium henningsii . Usnic acid amide also shows moderate antifungal activity and inhibiton of protein kinase C.
Tetrahedron Letters | 1996
Min Chu; Ronald Mierzwa; Imbi Truumees; Arthur King; Mahesh Patel; John Pichardo; Andrea Hart; Bimal Dasmahapatra; Pradip R. Das; Mohindar S. Puar
A new secondary metabolite, Sch 65676 (1), was isolated from the fermentation broth of a fungal culture. The structure of 1 was elucidated based on comprehensive NMR studies including COSY, NOE and HMBC experiments. Compound 1 displays inhibitory activity against the cytomegalovirus (CMV) protease.
The Journal of Antibiotics | 2007
Shu-Wei Yang; Ronald Mierzwa; Joseph Terracciano; Mahesh Patel; Vincent P. Gullo; Nicole Wagner; Bahige M. Baroudy; Mohindar S. Puar; Tze-Ming Chan; Min Chu
A novel fungal secondary metabolite, Sch 213766 was isolated from the fungal fermentation broth of Chaetomium globosum as the chemokine receptor CCR-5 inhibitor and shown to be the methyl ester of the previously described tetramic acid Sch 210972 on the basis of UV, MS and NMR spectral data analyses. Sch213766 exhibited an IC50 value of 8.6 μM in the CCR-5 receptor in vitro binding assay.
Tetrahedron Letters | 1998
Min Chu; Imbi Truumees; Ronald Mierzwa; Joseph Terracciano; Mahesh Patel; Pradip R. Das; Mohindar S. Puar; Tse-Ming Chan
Abstract A novel antifungal agent, Sch 56036 ( 1 ), was isolated from the fermentation culture broth of an Actinoplanes sp. Structure elucidation of 1 was accomplished by the analysis of spectroscopic data. Compound 1 was identified as a new polycyclic xanthone. Biological evaluation of 1 indicated that the compound possesses broad spectrum antifungal activity against various yeasts and dermatophytes with geometric mean MIC values ranging from 0.017∼0.031 μg/mL, respectively.