Rosália Gouveia Filizola
Federal University of Paraíba
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Revista Brasileira de Ginecologia e Obstetrícia | 2000
Rilva Lopes de Sousa; Eduardo Sérgio Soares Sousa; José Carlos Barros Silva; Rosália Gouveia Filizola
Purpose: based on the knowledge that the reliability of an instrument is essential for a correct interpretation of the results of research, the purpose of the present study is to evaluate the reliability of one of the menopausal indexes more often used in clinical practice and research, the Blatt and Kupperman Menopausal Index (BKMI). Methods: the population consisted of 60 climacteric patients attended at the Gynecology Outpatient Clinic of the Lauro Wanderley University Hospital of the Federal University of Paraiba in Joao Pessoa city. The reliability coefficient was analyzed by the test-retest method, whose application was done on two different occasions with an interval of four weeks, without administration of medicines. Results: the variation of the score observed with the application of BKMI at the first measurement was 2 to 41, with a median of 18 and mean of 18.8 (± 10.76), while at the second measurement, the menopausal index was 20.2 (± 10.51), median 19, and values ranging from 2 to 39. Despite these results, a Speaman (rs) coefficient of 0.68 (p = 0.001), which is a coefficient of only moderate intensity, was observed. Conclusions: the test-retest reliability in the application of the BKMI shows that, although this instrument presented a statistically moderate reliability, the intensity observed does not represent a reliable measurement. Considering that a correlational study is only a type of screening of the quality of a measurement method, we concluded that other studies must be performed with the purpose of evaluating the reliability and the validity of the BKMI. It is possible that the attribuition of different values to the items of BKMI and the inclusion of symptoms directly related to the estrogenic defficiency, like symptoms of vaginal atrophy, would make the instrument more reliable.
Maturitas | 2009
Rilva Lopes de Sousa-Muñoz; Rosália Gouveia Filizola
OBJECTIVES To evaluate the efficacy of soy isoflavones extract (SIE) in the treatment of depressive symptoms in women with climacteric syndrome. METHODS Placebo-controlled double-blind randomized study with 84 climacteric outpatients attended in the Lauro Wanderley University Hospital in Joao Pessoa (PB), Brazil. In the assessment of the depressive symptoms, the Brazilian version of the Center of Epidemiologic Studies of Depression (CES-D) scale was used, on the pre-treatment visits (VT1), 8th (VT2) and 16th (VT3) weeks after treatment. The experimental group (EG) received the daily dose of 120mg SIE and the control group (CG), placebo. The primary efficacy measure was the comparison of the percent reductions in the CES-D scores from VT1 to VT3 between EG and CG (t-test, p<0.05). The security analysis consisted of laboratory and clinical evaluation of adverse events. RESULTS The CES-D scores in the EG reduced from 12.5 (+/-4.2) in VT1 to 9.9 (+/-3.6) in VT2 (VT2<VT1, p=0.001) and 8.2 (+/-3.8) in VT3 (VT3<VT2, p=0.007), while the CG, reduced from 13.0 (+/-4.8) in VT1 to 10.1 (+/-4.1) in VT2 (VT2<VT1, p=0.001) and 9.4 (+/-4.1) in VT3 (VT2=VT3, p>0.05). In the outcome of the 16-week treatment (VT1-VT3), reduction of the CES-D scores did not reach statistical significance between groups. There were no clinically relevant adverse events attributable to the treatment. CONCLUSIONS The treatment with soy isoflavones did not produce significant reduction on the depressive symptoms of a predominantly affective nature evaluated in this study. The symptomatic reduction initially observed was apparently a nonspecific response to treatment, corroborating evidences from the literature on the placebo phenomenon in treatment of the climacteric syndrome.
Revista Brasileira de Ginecologia e Obstetrícia | 2006
Rilva Lopes de Sousa; Rosália Gouveia Filizola; Margareth de Fátima Formiga Melo Diniz; Eduardo Sérgio Soares Sousa; João Leonardo Ribeiro de Moraes
PURPOSE: to evaluate the efficacy of the use of isoflavones in the treatment of depressive symptoms in climacteric women. METHODS: placebo-controlled, randomized double-blind experimental study with 84 climacteric women who were assisted at the Lauro Wanderley University Hospital Ambulatory, in Joao Pessoa, Paraiba, Brazil. In the evaluation of the depressive symptoms the Self-evaluation questionnare of Hamiltons rating scale for depresion (QAEH-D) was used in the pretreatment visit (VT1), and in the 8th (VT2) and 16th (VT3) week after treatment. The experimental group (GExp) received soy extract with isoflavones, 120 mg per day, and the control group (GCont), placebo. The comparison of the scores of the QAEH-D between the VT1, VT2 and VT3 groups constituted the primary measure of efficacy (t test, p 0.05). From VT1 to VT3, there was a significant difference (8.9%) in the reduction of the scores between GExp and GCont (p=0.03). There was no correlation between the reduction of the depressive symptoms and alterations of the vasomotor symptoms (p>0.05). There was a reduction of FSH concentrations only in GExp (p=0.02), without estradiol modifications. Side effects were not clinically relevant. CONCLUSIONS: the effect of soy isoflavones was superior to the placebo, however, of small magnitude and only identified after 8 weeks of treatment. This small effect attributed to the experimental treatment, of good tolerability, may benefit patients who have side effects due to estradiol, or those who prefer not to use hormones.
Archives of Gerontology and Geriatrics | 2012
Rafaella Cristhine Pordeus Luna; Christiane Carmem Costa do Nascimento; Luiza Sonia Rios Asciutti; Sylvia do Carmo Castro Franceschini; Rosália Gouveia Filizola; Alcides da Silva Diniz; Ronei Marcos de Moraes; Maria Amélia Amado Rivera; Maria da Conceição Rodrigues Gonçalves; Maria José de Carvalho Costa
The aim of this study was to evaluate the relationships between fasting glucose levels, hs-CRP, BMI and serum retinol and diet in elderly people. For this study, a cross-sectional, epidemiological, population-based format was adopted. One hundred and sixty-three individuals between 60 and 90 years of age participated; the participants were from different socioeconomic and health backgrounds, except for the individuals diagnosed with diabetes. Most subjects had serum concentrations in the reference ranges for all variables. There was not a significant relationship between fasting glucose and serum retinol or diet. There was a significant correlation between hs-CRP and BMI (r=0.22, p=0.0082) and hs-CRP and total calorie intake (p=0.0091), which reinforces the notion that an increased intake of calories results in being overweight and/or obese. Considering the importance of vitamin A in various physiological processes, more studies on these relationships are necessary to establish a recommendation of vitamin A for the treatment and prevention of changes in fasting glucose and obesity in the elderly population.
Arquivos De Neuro-psiquiatria | 2006
Maurus Marques de Almeida Holanda; Rosália Gouveia Filizola; Maria José de Carvalho Costa; Emerson Magno Fernandes de Andrade; José Alberto Gonçalves da Silva
UNLABELLED Strokes are one of the most common causes of mortality and long term severe disability. Risk factors for stroke include: age, gender, diabetes mellitus (DM), hypertension, and many others. OBJECTIVE To evaluate obesity and hypertension in patients affected by acute ischemic stroke. METHOD We compared the anthropometric variables between type II diabetic patients and non-diabetic patients. We evaluated a total of 60 patients, divided into two groups: 34 non-diabetic patients and a group of 26 type II diabetic subjects. RESULTS The predominance of obesity, as well as hypertension, was very high among the studied groups, presenting no differences among the waist-hip ratio (WHR) values of the study group compared to the ones of the control group. CONCLUSION The predominance of obesity was very high among the studied groups and there was prevalence the android type obesity. There was no significative difference in the anthropometric evaluation by the measurement of WHR and the waist in the groups.
International Journal of Environmental Research and Public Health | 2014
Jousianny Patrício da Silva; Raquel Patrícia Ataíde Lima; Danielle de Carvalho Pereira; Cassia Surama de Oliveira Silva; Maria da Conceição Rodrigues Gonçalves; Malaquias Batista Filho; Rosália Gouveia Filizola; Ronei Marcos de Moraes; Luiza Sonia Rios Asciutti; Maria José de Carvalho Costa
The aim of this study was to analyze the association between waist-to-height ratio (WHtR) and C-reactive protein (CRP) in the elderly (considering their most prevalent morbidities and lifestyles), to investigate the relationship between this anthropometric index and the presence of the most prevalent morbidities (isolated or combined), and to identify which morbidities (analyzed individually) would have greater associations with WHtR. This cross-sectional population-based epidemiological study of a stratified sampling comprised 170 elderly individuals between 60 and 90 years of age (both genders). Home visits were used to administer questionnaires and to perform anthropometric measurements and blood collection. The mean patient age was younger than 70 years, with women comprising the majority (69.41%) and with 90% of the patients presenting with inadequate WHtR. Hypertension was the most prevalent morbidity in this cohort (58.52%), and when analyzed in combination, hypertension plus obesity were the most frequently diagnosed morbidities (17.65%). Obesity, which was among the most prevalent comorbidities, was the only comorbidity combined with WHtR (p = 0.0019). Individuals with no morbidities had lower mean WHtR values compared with individuals with at least one morbidity (p = 0.0075). In the multiple linear regression model, it was identified that when individuals had one or more of the most prevalent comorbidities, the mean WHtR increased by 0.0415 (p = 0.0065). A correlation between WHtR and CRP (p = 0.0379) was also verified. Based on the relationships observed between WHtR (isolated or in combination, data unpublished) and CRP among the elderly, WHtR may represent a screening tool because it is a simple and effective anthropometric index.
Nutrition Journal | 2013
Danielle de Carvalho Pereira; Raquel Patrícia Ataíde Lima; Roberto Teixeira de Lima; Maria da Conceição Rodrigues Gonçalves; Liana Clébia Soares Lima de Morais; Sylvia do Carmo Castro Franceschini; Rosália Gouveia Filizola; Ronei Marcos de Moraes; Luiza Sonia Rios Asciutti; Maria José de Carvalho Costa
Arquivos De Neuro-psiquiatria | 2004
Maurus Marques de Almeida Holanda; Rosália Gouveia Filizola; Maria José de Carvalho Costa; Rodrigo Vasconcelos Correia Lima de Andrade; José Alberto Gonçalves da Silva
Revista brasileira de medicina | 2003
Rilva Lopes de Sousa; Rosália Gouveia Filizola; João Leonardo Ribeiro de Moraes
Revista Saúde & Ciência Online | 2010
Maurus Marques de Almeida Holanda; Rosália Gouveia Filizola; Maria José de Carvalho Costa; Luiz Márcio de Brito Marinho Segundo; Daniel de Araújo Paz