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Dive into the research topics where Rose Swansburg is active.

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Featured researches published by Rose Swansburg.


Psychiatry and Clinical Neurosciences | 2016

Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression.

Xiao-Ru Yang; Lisa Marie Langevin; Natalia Jaworska; Adam Kirton; R. Marc Lebel; Ashley D. Harris; Yamile Jasaui; T. Christopher Wilkes; Mariko Sembo; Rose Swansburg; Frank P. MacMaster

Structural, functional, and metabolic changes in the dorsolateral prefrontal cortex (DLPFC) are implicated in the pathogenesis of major depressive disorder (MDD). We used proton magnetic resonance spectroscopy (1 H‐MRS) to examine the metabolite choline (glycerophosphocholine plus phosphocholine), which is used as an index of membrane integrity in the left DLPFC, in adolescents and young adults with MDD who were treatment‐resistant and had a positive family history compared to healthy controls. Differences in the choline resonance indicate an imbalance between synthesis and degradation activity of neuronal and glia membrane phospholipids.


Journal of Affective Disorders | 2017

A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression

Danielle Lefebvre; Lisa Marie Langevin; Natalia Jaworska; Ashley D. Harris; R. Marc Lebel; Yamile Jasaui; Adam Kirton; T. Christopher Wilkes; Mariko Sembo; Rose Swansburg; Frank P. MacMaster

BACKGROUND Smaller hippocampal volumes, as assessed by magnetic resonance imaging (MRI), and proton magnetic resonance spectroscopy (1H-MRS) indexed alterations in brain metabolites have been identified in adults with major depressive disorder (MDD). Our group has found similar effects in MDD youth. However, this has not been studied in youth with treatment resistant MDD (TRD), nor has the interaction between regional N-acetyl-aspartate and volume deficits. N-acetyl-aspartate is an amino acid in the synthesis pathway of glutamate, and serves a marker of neuronal viability/number. METHODS Fifteen typically developing youth (16-22 years of age; 7 males, 8 females) and eighteen youth with TRD (14-22 years of age; 8 males, 10 females) underwent 1H-MRS and MRI on a 3T scanner. A short echo PRESS protocol was used with voxels in the right and left hippocampi (6mL each). Hippocampal volume was evaluated using FreeSurfer. RESULTS Compared with the typically developing group, youth with TRD had lower concentrations of N-acetyl-aspartate in the left hippocampus (p=0.004), and a trend for smaller left hippocampal volume (p=0.067). In TRD subjects, hippocampal N-acetyl-aspartate was inversely correlated with left (r=-0.68, p=0.003) but not right hippocampal volume. Right hippocampal glutamate+glutamine was greater in TRD youth compared to typically developing controls (p=0.007). CONCLUSIONS These results suggest a neurochemical and structural deficit in the hippocampi of youth with TRD. These findings fit with the role of N-acetyl-aspartate in glutamate neurotransmission and the effect of glutamate on brain morphology.


Academic Psychiatry | 2017

Academic Productivity in Psychiatry: Benchmarks for the H-Index

Frank P. MacMaster; Rose Swansburg; Katherine Rittenbach

ObjectiveBibliometrics play an increasingly critical role in the assessment of faculty for promotion and merit increases. Bibliometrics is the statistical analysis of publications, aimed at evaluating their impact. The objective of this study is to describe h-index and citation benchmarks in academic psychiatry.MethodsFaculty lists were acquired from online resources for all academic departments of psychiatry listed as having residency training programs in Canada (as of June 2016). Potential authors were then searched on Web of Science (Thomson Reuters) for their corresponding h-index and total number of citations.ResultsThe sample included 1683 faculty members in academic psychiatry departments. Restricted to those with a rank of assistant, associate, or full professor resulted in 1601 faculty members (assistant = 911, associate = 387, full = 303). h-index and total citations differed significantly by academic rank. Both were highest in the full professor rank, followed by associate, then assistant. The range in each, however, was large.ConclusionsThis study provides the initial benchmarks for the h-index and total citations in academic psychiatry. Regardless of any controversies or criticisms of bibliometrics, they are increasingly influencing promotion, merit increases, and grant support. As such, benchmarking by specialties is needed in order to provide needed context.


Brain Stimulation | 2017

Pilot study of supplementary motor area rTMS for Tourette's syndrome in children

Cynthia Kahl; Adam Kirton; T. Pringsheim; Paul E. Croarkin; Quinn McLellan; Rose Swansburg; E. Zewdie; Frank P. MacMaster

of task irrelevant, competing stimuli (interference control) and in the inhibition of prepotent responses. The brain region most prominently associated with these aspects of inhibition control is the right inferior frontal gyrus (rIFG) which shows structural and functional alterations in ADHD. In our talk, we will give an overview over different approaches using transcranial direct current stimulation (tDCS) of the rIFG in healthy adults and will present findings from two of our own studies with ADHD youth targeting the rIFG.


Journal of Affective Disorders | 2018

History of suicide attempt and right superior temporal gyrus volume in youth with treatment-resistant major depressive disorder

Quinn McLellan; T. Christopher Wilkes; Rose Swansburg; Natalia Jaworska; Lisa Marie Langevin; Frank P. MacMaster

BACKGROUND Growing evidence suggests an endophenotype for suicidality, including brain morphometric features, could provide an improved platform for suicide risk assessment. Reduced right superior temporal gyrus (rSTG) volumes have been implicated in suicidality across psychiatric disorders. Treatment-resistant depression (TRD) has unique neurobiology and adolescents with TRD are at increased suicide risk. Here, we investigated whether reduced rSTG volume was present in adolescents with TRD and history of suicide attempt. METHODS 45 adolescents - 14 with history of suicide attempt and TRD, 14 without a suicide attempt history and TRD, and 17 healthy controls - underwent magnetic resonance imaging and reconstructed rSTG volumes were compared. Depressive and anxious symptoms were assessed with Hamilton depression and anxiety rating scales, and differences between attempters and non-attempters were explored. RESULTS Adolescents with TRD and history of suicide attempt showed reduced rSTG volume compared to healthy controls. Exploratory analyses revealed greater diurnal variation in depressive symptoms in the suicide attempt group compared to non-attempters. LIMITATIONS Sample size and temporal separation between suicide attempt date and data collection limits interpretation of findings. CONCLUSIONS Reduced rSTG volume may serve as a marker of suicide attempt in adolescence and specific symptom features may have a role in suicide risk assessment. Presently, risk assessment is limited by patient self-report and clinical judgement. A biological model of suicidality will be key to improve risk assessment and could lead to novel treatment approaches. Our findings extend previous results and contribute to our neurobiological understanding of suicidality.


Biological Psychiatry | 2018

F51. Investigating the Effect of Glutamate on Executive Functions in Children with Attention-Deficit/Hyperactivity Disorder Using Magnetic Resonance Spectroscopy

Tasmia Hai; Hanna A. Kubas; Jean-Francois Lemay; Rose Swansburg; Frank P. MacMaster


Biological Psychiatry | 2018

S110. Open Trial of Repetitive Transcranial Magnetic Stimulation in Youth With Treatment-Resistant Major Depression

Frank P. MacMaster; Paul E. Croarkin; T. Christopher Wilkes; Quinn McLellan; Lisa Marie Langevin; Natalia Jaworska; Rose Swansburg; Yamile Jasaui; Ephrem Zewdie; Patrick Ciechanski; Adam Kirton


Biological Psychiatry | 2018

F165. Resting Motor Threshold in Adolescents With Major Depressive Disorder

Wanjae Cho; Adam Kirton; Ephrem Zewdie; Cynthia Kahl; Rose Swansburg; Frank P. MacMaster


Biological Psychiatry | 2018

O4. Right Superior Temporal Gyrus Volume as a Biomarker of History of Suicide Attempt in Youth With Treatment-Resistant Major Depressive Disorder

Quinn McLellan; T. Christopher Wilkes; Rose Swansburg; Natalia Jaworska; Lisa Marie Langevin; Frank P. MacMaster


Biological Psychiatry | 2018

T55. Developmental Trajectory of Scalp to Cortex Distance: Implications of Transcranial Magnetic Stimulation in Adolescents With Major Depressive Disorder

Jessica Izquierdo; Quinn McLellan; Adam Kirton; Ephrem Zewdie; Cynthia Kahl; Rose Swansburg; Frank P. MacMaster

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