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Roshantha A. Chandraratna

University of Texas at Austin

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Publication

Featured researches published by Roshantha A. Chandraratna.

Bioorganic & Medicinal Chemistry Letters | 1994

Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs

Richard L. Beard; Daniel W. Gil; Deborah K. Marler; Elizabeth Henry; Diana F. Colon; Samuel J. Gillett; Taghreed Arefieg; Timothy S. Breen; Heather A. Krauss; Peter J. A. Davies; Roshantha A. Chandraratna

Abstract Retinoids elicit their biological actions by activating nuclear receptors that regulate gene transcription. There are six known retinoid receptors which belong to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) families. We report RXR-active stilbene retinoid analogs and discuss the structural features that impart RAR and RXR activation properties to compounds of this class.

Archive | 1998

Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities

Elliott S. Klein; Alan T. Johnson; Andrew M. Standeven; Richard L. Beard; Samuel J. Gillett; Tien T. Duong; Sunil Nagpal; Vidyasagar Vuligonda; Min Teng; Roshantha A. Chandraratna

Archive | 1993

Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity

Peter A. J. Davies; Roshantha A. Chandraratna

Archive | 1996

Method of identifying negative hormone and/or antagonist activities

Elliott S. Klein; Sunil Nagpal; Roshantha A. Chandraratna

Archive | 1994

Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity

Vidyasagar Vuligonda; Richard L. Beard; Alan T. Johnson; Min Teng; Tae K. Song; Roshantha A. Chandraratna

Archive | 1996

2,4-pentadienoic acid derivatives having retinoid-like biological activity

Vidyasagar Vuligonda; Roshantha A. Chandraratna

Archive | 1995

[4-(1,2-epoxycyclohexanyl)but-3-en-1-ynyl]aromatic and heteroaromatic acids and derivatives having retinoid-like biological activity

Roshantha A. Chandraratna; Richard L. Beard

Archive | 1994

Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity

Vidyasagar Vuligonda; Richard L. Beard; Roshantha A. Chandraratna

Archive | 2000

Compounds having activity as inhibitors of cytochrome P450RAI

Jayasree Vasudevan; Alan T. Johnson; Dehua Huang; Roshantha A. Chandraratna

Archive | 2002

Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity

Alan T. Johnson; Min Teng; Vidyasagar Vuligonda; Richard L. Beard; Samuel J. Gillett; Tien T. Duong; Roshantha A. Chandraratna

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Richard L. Beard

DuPont

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Vidyasagar Vuligonda

DuPont

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Jayasree Vasudevan

DuPont

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Tien T. Duong

DuPont

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Min Teng

DuPont

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Xiaoxia Liu

DuPont

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Diana F. Colon

DuPont

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Kwok Yin Tsang

DuPont

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Sunil Nagpal

Eli Lilly and Company

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Samuel J. Gillett

DuPont

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