Rudolf Furrer
University of Toronto
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Rudolf Furrer.
FEBS Letters | 2005
Nandita Shangari; Flore Depeint; Rudolf Furrer; W. Robert Bruce; Peter J. O’Brien
We hypothesized that in marginal thiamin deficiency intracellular α‐oxoaldehydes form macromolecular adducts that could possibly be genotoxic in colon cells; and that in the presence of oxidative stress these effects are augmented because of decreased detoxification of these aldehydes. We have demonstrated that reduced dietary thiamin in F344 rats decreased transketolase activity and increased α‐oxoaldehyde adduct levels. The methylglyoxal protein adduct level was not affected by oral glyoxal or methylglyoxal in the animals receiving thiamin at the control levels but was markedly increased in the animals on a thiamin‐reduced diet. These observations are consistent with our suggestion that the induction of aberrant crypt foci with marginally thiamin‐deficient diets may be a consequence of the formation of methylglyoxal adducts.
Nutrition and Cancer | 2016
Kai Yang; Sara Fard; Rudolf Furrer; Michael C. Archer; W. Robert Bruce; HoYin Lip; Rhea Mehta; Peter J. O'Brien; Adria Giacca; Wendy E. Ward; A. Pietro Femia; Giovanna Caderni; Alan Medline; Kate Banks
ABSTRACT Epidemiological studies have demonstrated clear associations between specific dietary and environmental risk factors and incidence of colorectal cancer, but the mechanisms responsible for these associations are not known. An animal model could facilitate such an understanding. Both genotoxic and nongenotoxic carcinogens induce aberrant crypt foci (ACF) in the colons of F344 rats. F344 rats were provided with diets that contained putative risk factors for CRC: low calcium and low vitamin D, high iron, high fructose, and decreased light (UV) exposure or a control diet for 14 wk. The rats were then assessed with biochemical measures and by topological examination for evidence of colon abnormalities. Circulating ionized calcium was decreased from 2.85 to 1.69 mmol/L, and ACF were increased from 0.7 to 13.6 lesions/colon (both P < 0.001). Rats exposed to the multiple environmental conditions associated with colon cancer, developed ACF similar to the heterogeneous or ill-defined ACF in the human colon. Heterogeneous ACF are the most frequently seen in humans and are also seen in rats shortly after exposure to the non-genotoxic colon carcinogen, dextransulfate sodium. The rodent model could be used to assess the pathways from diet and environment to colon cancer and to provide guidance for clinical studies.
Biochemistry | 1983
Indranil Gupta; J. Baptista; W. Robert Bruce; C. Tim Che; Rudolf Furrer; Jean S. Gingerich; Arthur A. Grey; Lajos Marai; Peter Yates; Jiri J. Krepinsky
Cancer Research | 1979
Tadao Kakizoe; Tusn-Tien Wang; Vincent W.S. Eng; Rudolf Furrer; Peter Dion; W. Robert Bruce
Cancer Letters | 2003
W. Robert Bruce; Rudolf Furrer; Nandita Shangari; Peter J. O'Brien; Alan Medline; Yanping Wang
Chemico-Biological Interactions | 2007
Nandita Shangari; Flore Depeint; Rudolf Furrer; W. Robert Bruce; Marija Popovic; Feng Zheng; Peter J. O’Brien
Nutrition Research | 2007
Flore Depeint; Nandita Shangari; Rudolf Furrer; W. Robert Bruce; Peter J. O'Brien
Archive | 2007
Jiri J. Krepinsky; Rudolf Furrer; Ka Sing Yeung
Canadian Journal of Chemistry | 2003
Jiri J. Krepinsky; Gabor P Kandel; Ka Sing Yeung; Jacek Chociej; Min Chen; Gideon Cohen; Stephen P. Douglas; Rudolf Furrer; Vishal Kukreti; Niculina Lupescu; Enoka Richens; Keith L Tanner
Archive | 2011
Jiri J. Krepinsky; Rudolf Furrer; Ka Sing Yeung