Ruhul Kuddus

Pharmacological Activities of Blumea lacera (Burm. f) DC: A Medicinal Plant of Bangladesh

Aims: The crude methanol extract of whole plant of Blumea lacera (Burn.f.) DC. has been investigated for anti-diarrheal, antimicrobial, anxiolytic, anti-atherothrombosis, membrane stabilizing and alpha-amylase inhibitory activities. Place and Duration of Study: The study was carried out in 2013 in the Department of Pharmacy, Southern University Bangladesh, Chittagong, Bangladesh. Methodology: Test for anti-diarrheal activity was carried out by castor oil-induced diarrhea in mice. The preliminary antimicrobial activity was determined by the agar disc diffusion method. The anxiolytic activity was examined in mice by using the hole board test and open field test (OFT). The anti-atherothrombosis activity was evaluated using standard streptokinase. The membrane stabilizing activity was assessed by using hypotonic solution induced hemolysis of human erythrocyte. The plant extract was also assessed for anti-diabetic ability using In vitro α-amylase inhibitory potential. The αamylase inhibitory activity of B. lacera was measured using the starch-iodine method.

Comparative in vitro-in vivo correlation analysis with pioglitazone tablets

Objective nTo assess the in vitro-in vivo correlation of immediate release formulation of pioglitazone 30 mg film coated tablet.